Search Results - "Tang, Yuning J"

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis by Tsushima, Hidetoshi, Tang, Yuning J, Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J, Hilton, Matthew J, Alman, Benjamin A

“…During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated…”
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High-Throughput Identification, Modeling, and Analysis of Cancer Driver Genes In Vivo by Tang, Yuning J, Shuldiner, Emily G, Karmakar, Saswati, Winslow, Monte M

“…The vast number of genomic and molecular alterations in cancer pose a substantial challenge to uncovering the mechanisms of tumorigenesis and identifying…”
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Mutant IDH is sufficient to initiate enchondromatosis in mice by Hirata, Makoto, Sasaki, Masato, Cairns, Rob A, Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y, Snow, Bryan E, Jones, Lisa D, Wei, Qingxia, Sato, Shingo, Tang, Yuning J, Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W, Alman, Benjamin A

“…Significance Current genomic and biochemical analysis revealed mutations in isocitrate dehydrogenase ( IDH ) genes associated with several neoplasms and a…”
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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis by Tang, Yuning J., Huang, Jianguo, Tsushima, Hidetoshi, Ban, Ga I., Zhang, Hongyuan, Oristian, Kristianne M., Puviindran, Vijitha, Williams, Nerissa, Ding, Xiruo, Ou, Jianhong, Jung, Sin-Ho, Lee, Chang-Lung, Jiao, Yiqun, Chen, Benny J., Kirsch, David G., Alman, Benjamin A.

“…Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor…”
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Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype by Sato, Shingo, Tang, Yuning J., Wei, Qingxia, Hirata, Makoto, Weng, Angela, Han, Ilkyu, Okawa, Atsushi, Takeda, Shu, Whetstone, Heather, Nadesan, Puvindran, Kirsch, David G., Wunder, Jay S., Alman, Benjamin A.

“…The cell of origin for most mesenchymal tumors is unclear. One cell type that contributes to this lineages is the pericyte, a cell expressing Ng2/Cspg4. Using…”
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Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma by Wei, Qingxia, Tang, Yuning J, Voisin, Veronique, Sato, Shingo, Hirata, Makoto, Whetstone, Heather, Han, Ilkyu, Ailles, Laurie, Bader, Gary D, Wunder, Jay, Alman, Benjamin A

“…Tumor-propagating cells (TPCs) are believed to drive cancer initiation, progression and recurrence. These cells are characterized by enhanced tumorigenicity…”
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Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair by Yahara, Yasuhito, Barrientos, Tomasa, Tang, Yuning J., Puviindran, Vijitha, Nadesan, Puviindran, Zhang, Hongyuan, Gibson, Jason R., Gregory, Simon G., Diao, Yarui, Xiang, Yu, Qadri, Yawar J., Souma, Tomokazu, Shinohara, Mari L., Alman, Benjamin A.

“…Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing…”
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The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice by Hu, Guoli, Yu, Yilin, Tang, Yuning J, Wu, Colleen, Long, Fanxin, Karner, Courtney M

“…ABSTRACT Skeletal stem/progenitor cells (SSPC) are critical regulators of bone homeostasis by providing a continuous supply of osteoblasts throughout life. In…”
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Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations by Zhang, Hongyuan, Puviindran, Vijitha, Nadesan, Puviindran, Ding, Xiruo, Shen, Leyao, Tang, Yuning J, Tsushima, Hidetoshi, Yahara, Yasuhito, Ban, Ga I, Zhang, Guo‐Fang, Karner, Courtney M, Alman, Benjamin A.

“…ABSTRACT Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant, respectively. The majority of these tumors harbor…”
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Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma by Zhang, Hongyuan, Wei, Qingxia, Tsushima, Hidetoshi, Puviindran, Vijitha, Tang, Yuning J, Pathmanapan, Sinthu, Poon, Raymond, Ramu, Eyal, Al-Jazrawe, Mushriq, Wunder, Jay, Alman, Benjamin A

“…Enchondroma and chondrosarcoma are the most common benign and malignant cartilaginous neoplasms. Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are…”
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Erythromyeloid progenitors give rise to a population of osteoclasts contributing to bone homeostasis and repair by Yahara, Yasuhito, Barrientos, Tomasa, Tang, Yuning J., Puviindran, Vijitha, Nadesan, Puviindran, Zhang, Hongyuan, Gibson, Jason, Gregory, Simon G., Diao, Yarui, Xiang, Yu, Qadri, Yawar J., Souma, Tomokazu, Shinohara, Mari L., Alman, Benjamin A.

“…The osteoclast is a multinucleated monocyte/macrophage lineage cell that degrades bone. Here we used lineage tracing studies, labeling cells expressing Cx3cr1…”
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Abstract B108: Integrated in vivo dissection of metastatic phenotypes and molecular programs in pancreatic ductal adenocarcinoma by Karmakar, Saswati, Lyulina, Anastasia, Xiong, Xiaochen, Tang, Yuning J., Lopez, Steven, Hughes, Nicolas William, Attardi, Laura, Petrov, Dmitri A., Winslow, Monte M.

“…Abstract The ability of pancreatic ductal adenocarcinoma (PDAC) cells to form tissue destructive metastases remains a critical impediment to therapy…”
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Abstract IA025: Using genetically engineered mouse models to study sarcoma metastasis by Kirsch, David G., Patel, Rutulkumar, Finkelstein, Sophie R., Ban, Joy, Tang, Yuning J, Huang, Jianguo, Alman, Benjamin A., Mowery, Yvonne M.

“…Abstract Despite aggressive conventional therapy, many patients with high-risk soft-tissue sarcoma develop metastatic disease. To investigate mechanism(s) of…”
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Abstract 821: Dissecting the role of Stag2 in lung adenocarcinoma by Ashkin, Emily L., Cai, Hongchen, Tang, Yuning J., Li, Chuan, Chew, Su Kit, Hung, King, Belk, Julia, Karmakar, Saswati, Hebert, Jess, Yousefi, Maryam, Swanton, Charles, Petrov, Dmitri A., Winslow, Monte

“…Abstract Lung cancer is the most common cause of cancer-related deaths worldwide. Cancers are driven by genomic alterations that activate tumor-promoting…”
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MutantIDHis sufficient to initiate enchondromatosis in mice by Hirata, Makoto, Sasaki, Masato, Cairns, Rob A., Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y., Snow, Bryan E., Jones, Lisa D., Wei, Qingxia, Sato, Shingo, Tang, Yuning J., Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W., Alman, Benjamin A.

“…Enchondromas are benign cartilage tumors and precursors to malignant chondrosarcomas. Somatic mutations in the isocitrate dehydrogenase genes (IDH1andIDH2) are…”
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