Search Results - "Tang, Ruhang"

Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis by Wu, Chia-Lung, Dicks, Amanda, Steward, Nancy, Tang, Ruhang, Katz, Dakota B., Choi, Yun-Rak, Guilak, Farshid

“…The therapeutic application of human induced pluripotent stem cells (hiPSCs) for cartilage regeneration is largely hindered by the low yield of chondrocytes…”
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Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway by Huynh, Nguyen Pt, Gloss, Catherine C, Lorentz, Jeremiah, Tang, Ruhang, Brunger, Jonathan M, McAlinden, Audrey, Zhang, Bo, Guilak, Farshid

“…The roles of long noncoding RNAs (lncRNAs) in musculoskeletal development, disease, and regeneration remain poorly understood. Here, we identified the novel…”
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Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice by Harasymowicz, Natalia S., Choi, Yun‐Rak, Wu, Chia‐Lung, Iannucci, Leanne, Tang, Ruhang, Guilak, Farshid

“…Objective Obesity and osteoarthritis (OA) are 2 major public health issues affecting millions of people worldwide. Whereas parental obesity affects the…”
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Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure by Chen, Jian-Fu, Murchison, Elizabeth P, Tang, Ruhang, Callis, Thomas E, Tatsuguchi, Mariko, Deng, Zhongliang, Rojas, Mauricio, Hammond, Scott M, Schneider, Michael D, Selzman, Craig H, Meissner, Gerhard, Patterson, Cam, Hannon, Gregory J, Wang, Da-Zhi

“…Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated…”
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Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells by Tang, Ruhang, Jing, Liufang, Willard, Vincent P, Wu, Chia-Lung, Guilak, Farshid, Chen, Jun, Setton, Lori A

“…Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular…”
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Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes by Dicks, Amanda R, Maksaev, Grigory I, Harissa, Zainab, Savadipour, Alireza, Tang, Ruhang, Steward, Nancy, Liedtke, Wolfgang, Nichols, Colin G, Wu, Chia-Lung, Guilak, Farshid

“…Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease…”
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Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5 by Espinoza-Lewis, Ramón A., Yu, Ling, He, Fenglei, Liu, Hongbing, Tang, Ruhang, Shi, Jiangli, Sun, Xiaoxiao, Martin, James F., Wang, Dazhi, Yang, Jing, Chen, YiPing

“…The pacemaker is composed of specialized cardiomyocytes located within the sinoatrial node (SAN), and is responsible for originating and regulating the heart…”
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N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions by Hwang, Priscilla Y, Jing, Liufang, Chen, Jun, Lim, Foon-Lian, Tang, Ruhang, Choi, Hyowon, Cheung, Kenneth M, Risbud, Makarand V, Gersbach, Charles A, Guilak, Farshid, Leung, Victor Y, Setton, Lori A

“…Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extracellular matrix that contributes to disc health and mechanical…”
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Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity by Tang, Ruhang, Harasymowicz, Natalia S, Wu, Chia-Lung, Collins, Kelsey H, Choi, Yun-Rak, Oswald, Sara J, Guilak, Farshid

“…Obesity-associated inflammation and loss of muscle function play critical roles in the development of osteoarthritis (OA); thus, therapies that target muscle…”
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Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury by Stansfield, William E., MD, Moss, Nancy C., MD, Willis, Monte S., MD, PhD, Tang, Ruhang, PhD, Selzman, Craig H., MD

“…Background Despite improvements in protection, myocardial ischemia-reperfusion remains an important cause of cardiac dysfunction. Multiple strategies exist…”
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A cell surface receptor mediates extracellular Ca2+ sensing in guard cells by SHENGCHENG HAN, RUHANG TANG, ANDERSON, Lisa K, WOERNER, Todd E, PEL, Zhen-Ming

“…Extracellular Ca2+ (Ca2+o) is required for various physiological and developmental processes in animals and plants. In response to varied Ca2+o levels, plants…”
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Inhibitory kappa-B kinase-β inhibition prevents adaptive left ventricular hypertrophy by Andersen, Nancy M., MD, Tang, Ruhang, PhD, Li, Ling, MS, Javan, Hadi, MD, Zhang, Xiu Quan, MD, Selzman, Craig H., MD

“…Abstract Background Most cardiovascular studies have implicated the central transcription factor nuclear factor kappa-B (NF-κB) as contributing to the…”
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Single tyrosine mutation in AAV8 and AAV9 capsids is insufficient to enhance gene delivery to skeletal muscle and heart by Qiao, Chunping, Yuan, Zhenhua, Li, Jianbin, Tang, Ruhang, Li, Juan, Xiao, Xiao

“…Site-directed mutations of tyrosine (Y) to phenylalanine (F) on the surface of adeno-associated viral (AAV) capsids have been reported as a simple method to…”
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Delayed NF-kappaB inhibition still provides cardioprotection from myocardial ischemia and reperfusion by Moss, Nancy C., MD, Stansfield, William E., MD, Tang, Ruhang, PhD, Selzman, Craig H., MD, FACS

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Cell cycle regulator, polo-like kinase 1, promotes regression of murine left ventricular hypertrophy, and is upregulated in human myocardium after mechanical circulatory support by Stansfield, William E., MD, Tang, Ruhang, PhD, Moss, Nancy C., MD, Selzman, Craig H., MD

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The phenotype and fate of synovial macrophages is modulated by injury and obesity in osteoarthritis by Harasymowicz, Natalia S., Harissa, Zainab, Rashidi, Neda, Tang, Ruhang, Guilak, Farshid

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033 - The phenotype and fate of synovial macrophages is modulated by injury and obesity in osteoarthritis by Harasymowicz, Natalia S., Harissa, Zainab, Rashidi, Neda, Tang, Ruhang, Guilak, Farshid

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Adipose tissue is a critical regulator of osteoarthritis by Collins, Kelsey H., Lenz, Kristin L., Pollitt, Eleanor N., Ferguson, Daniel, Hutson, Irina, Springer, Luke E., Oestreich, Arin K., Tang, Ruhang, Choi, Yun-Rak, Meyer, Gretchen A., Teitelbaum, Steven L., Pham, Christine T. N., Harris, Charles A., Guilak, Farshid

“…Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally affects individuals with obesity. The mechanisms by which obesity…”
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Single‐cell RNA sequencing reveals the induction of novel myeloid and myeloid‐associated cell populations in visceral fat with long‐term obesity by Harasymowicz, Natalia S., Rashidi, Neda, Savadipour, Alireza, Wu, Chia‐Lung, Tang, Ruhang, Bramley, John, Buchser, William, Guilak, Farshid

“…Macrophages and other immune cells are important contributors to obesity‐associated inflammation; however, the cellular identities of these specific…”
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Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis by Tang, Ruhang, Harasymowicz, Natalia S, Wu, Chia-Lung, Choi, Yun-Rak, Lenz, Kristin, Oswald, Sara J, Guilak, Farshid

“…Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary…”
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