Search Results - "Tang, Rachel"
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ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment
Published in Proceedings of the National Academy of Sciences - PNAS (18-08-2020)“…Although immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, many patients do not respond or develop resistance to ICB…”
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Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers
Published in Cancer research (Chicago, Ill.) (15-11-2017)“…Targeting mutant KRAS signaling pathways continues to attract attention as a therapeutic strategy for KRAS-driven tumors. In this study, we exploited the power…”
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Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors
Published in Scientific reports (15-04-2021)“…The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal…”
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Where does physical activity fit into preschool postpandemic? A qualitative exploration with parents, teachers and administrators
Published in BMJ open (07-05-2024)“…ObjectivesDuring the preschool years, children depend on adult caregivers to provide opportunities for physical activity (PA). Research has focused on…”
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Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2
Published in Scientific reports (19-04-2021)“…Two-pore channel 2 (TPC2) resides in endolysosomal membranes but also in lysosome-related organelles such as the melanin producing melanosomes…”
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Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Published in Nature communications (02-08-2022)“…Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that drive endocytic ion flux and membrane traffic. Here we show that…”
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Access to ultrasound imaging: A qualitative study in two northern, remote, Indigenous communities in Canada
Published in International journal of circumpolar health (01-01-2021)“…Ultrasound imaging is an essential component of healthcare services. This study sought to explore perceptions of access, and factors which shape access, to…”
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Duration of double balloon catheter for patients with prior cesarean: a before and after study
Published in AJOG global reports (01-08-2024)“…Previous studies that suggest a shorter time from cervical ripening balloon placement to delivery with shorter total balloon placement time have excluded…”
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Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
Published in Cell calcium (Edinburgh) (01-06-2020)“…The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a…”
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Navigating Power and Claiming Justice: Tenant Experiences at Saskatchewan’s Housing Law Tribunal
Published in The Windsor Yearbook of Access to Justice (18-09-2020)“…This article discusses a qualitative interview project where twenty tenants shared their experiences about having hearings at the Office of Residential…”
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JPT2: The missing link between intracellular Ca2+ release channels and NAADP?
Published in Cell calcium (Edinburgh) (01-07-2021)“…NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent second messenger releasing Ca2+ from endolysosomes through two-pore channels (TPCs) and from…”
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Publisher Correction: Internet image search outputs propagate climate change sentiment and impact policy support
Published in Nature climate change (18-11-2024)Get full text
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Internet image search outputs propagate climate change sentiment and impact policy support
Published in Nature climate change (13-11-2024)Get full text
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Extending the online focus group method using web-based conferencing to explore older adults online learning
Published in International journal of research & method in education (01-01-2020)“…This exploratory research documents the use of the web conference technology WebEx™ to expand the variety of focus group data collection methods. Drawn from…”
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KIAA1429/VIRMA promotes breast cancer progression by m 6 A-dependent cytosolic HAS2 stabilization
Published in EMBO reports (09-10-2023)“…N -methyladenosine (m A), the most abundant internal modification in eukaryotic mRNA, plays important roles in many physiological and pathological processes,…”
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Adequacy of glycemic control in early pregnancy with type 2 diabetes and perinatal outcomes
Published in American journal of obstetrics and gynecology (01-01-2023)Get full text
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Maternal weight gain among individuals with type 2 diabetes and associated perinatal outcomes
Published in American journal of obstetrics and gynecology (01-01-2023)Get full text
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KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization
Published in EMBO reports (09-10-2023)“…N6‐methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, plays important roles in many physiological and pathological processes,…”
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Bio-oil production via catalytic solvolysis of biomass
Published in RSC advances (01-01-2017)“…Recent studies have found that biomass has great potential as a substitute for natural fossil fuels. Although pyrolysis has always been the option for…”
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