Search Results - "Tang, Jean"

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma by Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., Li, Jiang R., Kim, Geurim, Rezaee, Melika, Ally, Mina S., Kim, Jinah, Yao, Catherine, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y.

“…Advanced basal cell carcinomas (BCCs) frequently acquire resistance to Smoothened (SMO) inhibitors through unknown mechanisms. Here we identify SMO mutations…”
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Gene Therapy for Epidermolysis Bullosa by Marinkovich, M. Peter, Tang, Jean Y.

“…Epidermolysis bullosa is a family of diseases characterized by blistering and fragility of the skin in response to mechanical trauma. Advances in our…”
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Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma by KIM, Daniel J, KIM, James, TANG, Jean Y, SPAUNHURST, Katrina, MONTOYA, Javier, KHODOSH, Rita, CHANDRA, Kalyani, FU, Teresa, GILLIAM, Anita, MOLGO, Monserrat, BEACHY, Philip A

“…Itraconazole, a US Food and Drug Administration-approved antifungal drug, inhibits the Hedgehog (HH) signaling pathway, a crucial driver of basal cell…”
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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas by Atwood, Scott X., Li, Mischa, Lee, Alex, Tang, Jean Y., Oro, Anthony E.

“…Atypical protein kinase C ι/λ is shown to be critical, through its regulation of the transcription factor GLI, for hedgehog-dependent processes, such as the…”
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Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists by Kim, James, Aftab, Blake T., Tang, Jean Y., Kim, Daniel, Lee, Alex H., Rezaee, Melika, Kim, Jynho, Chen, Baozhi, King, Emily M., Borodovsky, Alexandra, Riggins, Gregory J., Epstein, Ervin H., Beachy, Philip A., Rudin, Charles M.

“…Recognition of the multiple roles of Hedgehog signaling in cancer has prompted intensive efforts to develop targeted pathway inhibitors. Leading inhibitors in…”
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Distinguishing malignant from benign microscopic skin lesions using desorption electrospray ionization mass spectrometry imaging by Margulis, Katherine, Chiou, Albert S., Aasi, Sumaira Z., Tibshirani, Robert J., Tang, Jean Y., Zare, Richard N.

“…Detection of microscopic skin lesions presents a considerable challenge in diagnosing early-stage malignancies as well as in residual tumor interrogation after…”
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Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma by Sharpe, Hayley J., Pau, Gregoire, Dijkgraaf, Gerrit J., Basset-Seguin, Nicole, Modrusan, Zora, Januario, Thomas, Tsui, Vickie, Durham, Alison B., Dlugosz, Andrzej A., Haverty, Peter M., Bourgon, Richard, Tang, Jean Y., Sarin, Kavita Y., Dirix, Luc, Fisher, David C., Rudin, Charles M., Sofen, Howard, Migden, Michael R., Yauch, Robert L., de Sauvage, Frederic J.

“…Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several cancers. Vismodegib is approved for the treatment of locally advanced…”
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Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition by Tang, Yujie, Gholamin, Sharareh, Schubert, Simone, Willardson, Minde I, Lee, Alex, Bandopadhayay, Pratiti, Bergthold, Guillame, Masoud, Sabran, Nguyen, Brian, Vue, Nujsaubnusi, Balansay, Brianna, Yu, Furong, Oh, Sekyung, Woo, Pamelyn, Chen, Spenser, Ponnuswami, Anitha, Monje, Michelle, Atwood, Scott X, Whitson, Ramon J, Mitra, Siddhartha, Cheshier, Samuel H, Qi, Jun, Beroukhim, Rameen, Tang, Jean Y, Wechsler-Reya, Rob, Oro, Anthony E, Link, Brian A, Bradner, James E, Cho, Yoon-Jae

“…Cancers dependent on hedgehog pathway signaling are susceptible to the BET bromodomain inhibitor JQ1. Hedgehog signaling drives oncogenesis in several cancers,…”
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Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome by Tang, Jean Y, Mackay-Wiggan, Julian M, Aszterbaum, Michelle, Yauch, Robert L, Lindgren, Joselyn, Chang, Kris, Coppola, Carol, Chanana, Anita M, Marji, Jackleen, Bickers, David R, Epstein, Ervin H

“…In a randomized, placebo-controlled trial, the hedgehog-pathway inhibitor vismodegib prevented the development of new basal-cell carcinomas in patients with…”
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Update on metastatic basal cell carcinoma: a summary of published cases from 1981 through 2011 by Wysong, Ashley, Aasi, Sumaira Z, Tang, Jean Y

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Inhibition of the hedgehog pathway in patients with basal-cell nevus syndrome: final results from the multicentre, randomised, double-blind, placebo-controlled, phase 2 trial by Tang, Jean Y, MD, Ally, Mina S, MD, Chanana, Anita M, BS, Mackay-Wiggan, Julian M, MD, Aszterbaum, Michelle, MD, Lindgren, Joselyn A, MS, Ulerio, Grace, BA, Rezaee, Melika R, BA, Gildengorin, Ginny, PhD, Marji, Jackleen, MD, Clark, Charlotte, MD, Bickers, David R, Prof, Epstein, Ervin H, Dr

“…Summary Background Aberrant hedgehog signalling underlies the development of basal-cell carcinomas. We previously reported the interim analysis of a…”
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Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial by Yosipovitch, Gil, Ständer, Sonja, Kerby, Matthew B., Larrick, James W., Perlman, Andrew J., Schnipper, Edward F., Zhang, Xiaoming, Tang, Jean Y., Luger, Thomas, Steinhoff, Martin

“…The substance P/neurokinin 1 receptor pathway is critical in chronic pruritus; anecdotal evidence suggests that antagonism of this pathway can reduce chronic…”
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Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish by Goldshmit, Yona, Tang, Jean Kitty K Y, Siegel, Ashley L, Nguyen, Phong D, Kaslin, Jan, Currie, Peter D, Jusuf, Patricia R

“…Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently…”
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Advances in cutaneous squamous cell carcinoma by Winge, Mårten C. G., Kellman, Laura N., Guo, Konnie, Tang, Jean Y., Swetter, Susan M., Aasi, Sumaira Z., Sarin, Kavita Y., Chang, Anne Lynn S., Khavari, Paul A.

“…Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise transformation from healthy epithelium to premalignant dysplasia to…”
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Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma by Chahal, Harvind S., Lin, Yuan, Ransohoff, Katherine J., Hinds, David A., Wu, Wenting, Dai, Hong-Ji, Qureshi, Abrar A., Li, Wen-Qing, Kraft, Peter, Tang, Jean Y., Han, Jiali, Sarin, Kavita Y.

“…Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic…”
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Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa by Siprashvili, Zurab, Nguyen, Ngon T, Gorell, Emily S, Loutit, Kylie, Khuu, Phuong, Furukawa, Louise K, Lorenz, H. Peter, Leung, Thomas H, Keene, Douglas R, Rieger, Kerri E, Khavari, Paul, Lane, Alfred T, Tang, Jean Y, Marinkovich, M. Peter

“…IMPORTANCE: Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating, often fatal, inherited blistering disorder caused by mutations in the COL7A1…”
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Phase 2 trial of a neurokinin-1 receptor antagonist for the treatment of chronic itch in patients with epidermolysis bullosa: A randomized clinical trial by Chiou, Albert S., Choi, Sara, Barriga, Melissa, Dutt-Singkh, Yana, Solis, Daniel C., Nazaroff, Jaron, Bailey-Healy, Irene, Li, Shufeng, Shu, Kim, Joing, Mark, Kwon, Paul, Tang, Jean Y.

“…Chronic pruritus causes major morbidity in epidermolysis bullosa (EB). The substance P-neurokinin 1 receptor (SP-NK1) pathway is a promising target for…”
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Online, home‐based dystrophic epidermolysis bullosa registry by Mittal, Vaishali, Nazaroff, Jaron, Eid, Edward, Li, Shufeng, Linos, Eleni, Oro, Anthony, Tang, Jean Y.

“…Genetic testing is the gold standard for diagnosing different epidermolysis bullosa (EB) subtypes; however, testing rates are low. We conducted a pilot study…”
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Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas by Whitson, Ramon J, Lee, Alex, Urman, Nicole M, Mirza, Amar, Yao, Catherine Y, Brown, Alexander S, Li, Jiang R, Shankar, Gautam, Fry, Micah A, Atwood, Scott X, Lee, Eunice Y, Hollmig, S Tyler, Aasi, Sumaira Z, Sarin, Kavita Y, Scott, Matthew P, Epstein, Ervin H, Tang, Jean Y, Oro, Anthony E

“…A large proportion of basal cell carcinomas develop resistance independently of the canonical mutations in genes encoding hedgehog pathway components. An…”
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Overexpression of MiR‐335‐5p Promotes Bone Formation and Regeneration in Mice by Zhang, Lan, Tang, Yin, Zhu, Xiaofang, Tu, Tianchi, Sui, Lei, Han, Qianqian, Yu, Liming, Meng, Shu, Zheng, Leilei, Valverde, Paloma, Tang, Jean, Murray, Dana, Zhou, Xuedong, Drissi, Hicham, Dard, Michel M, Tu, Qisheng, Chen, Jake

“…ABSTRACT MicroRNAs (miRNAs) and the Wnt signaling pathway play critical roles in regulating bone development and homeostasis. Our previous study revealed high…”
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