Search Results - "Tang, Hsin Yao"

NAD+ metabolism governs the proinflammatory senescence-associated secretome by Nacarelli, Timothy, Lau, Lena, Fukumoto, Takeshi, Zundell, Joseph, Fatkhutdinov, Nail, Wu, Shuai, Aird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Schultz, David, Noma, Ken-ichi, Baur, Joseph A., Schug, Zachary, Tang, Hsin-Yao, Speicher, David W., David, Gregory, Zhang, Rugang

“…Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of…”
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Proximity labeling identifies a repertoire of site-specific R-loop modulators by Yan, Qingqing, Wulfridge, Phillip, Doherty, John, Fernandez-Luna, Jose L., Real, Pedro J., Tang, Hsin-Yao, Sarma, Kavitha

“…R-loops are three-stranded nucleic acid structures that accumulate on chromatin in neurological diseases and cancers and contribute to genome instability…”
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Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest by Cho, Sangkyun, Vashisth, Manasvita, Abbas, Amal, Majkut, Stephanie, Vogel, Kenneth, Xia, Yuntao, Ivanovska, Irena L., Irianto, Jerome, Tewari, Manorama, Zhu, Kuangzheng, Tichy, Elisia D., Mourkioti, Foteini, Tang, Hsin-Yao, Greenberg, Roger A., Prosser, Benjamin L., Discher, Dennis E.

“…Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (∼1 h) to actomyosin stress or ECM…”
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence by Zhao, Bo, Liu, Pingyu, Fukumoto, Takeshi, Nacarelli, Timothy, Fatkhutdinov, Nail, Wu, Shuai, Lin, Jianhuang, Aird, Katherine M., Tang, Hsin-Yao, Liu, Qin, Speicher, David W., Zhang, Rugang

“…Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory…”
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ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay by Sakurai, Masayuki, Shiromoto, Yusuke, Ota, Hiromitsu, Song, Chunzi, Kossenkov, Andrew V, Wickramasinghe, Jayamanna, Showe, Louise C, Skordalakes, Emmanuel, Tang, Hsin-Yao, Speicher, David W, Nishikura, Kazuko

“…In stressed cells, the ADAR1p110 isoform is phosphorylated and translocated from the nucleus to the cytoplasm, where it protects transcripts with 3′-UTR dsRNA…”
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Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy by Jiao, Xuanmao, Wang, Min, Zhang, Zhao, Li, Zhiping, Ni, Dong, Ashton, Anthony W, Tang, Hsin-Yao, Speicher, David W, Pestell, Richard G

“…Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200…”
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Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients by Giron, Leila B, Dweep, Harsh, Yin, Xiangfan, Wang, Han, Damra, Mohammad, Goldman, Aaron R, Gorman, Nicole, Palmer, Clovis S, Tang, Hsin-Yao, Shaikh, Maliha W, Forsyth, Christopher B, Balk, Robert A, Zilberstein, Netanel F, Liu, Qin, Kossenkov, Andrew, Keshavarzian, Ali, Landay, Alan, Abdel-Mohsen, Mohamed

“…A disruption of the crosstalk between the gut and the lung has been implicated as a driver of severity during respiratory-related diseases. Lung injury causes…”
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Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV by Giron, Leila B., Palmer, Clovis S., Liu, Qin, Yin, Xiangfan, Papasavvas, Emmanouil, Sharaf, Radwa, Etemad, Behzad, Damra, Mohammad, Goldman, Aaron R., Tang, Hsin-Yao, Johnston, Rowena, Mounzer, Karam, Kostman, Jay R., Tebas, Pablo, Landay, Alan, Montaner, Luis J., Jacobson, Jeffrey M., Li, Jonathan Z., Abdel-Mohsen, Mohamed

“…Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety…”
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MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer by Casciano, Jessica C., Perry, Caroline, Cohen-Nowak, Adam J., Miller, Katelyn D., Vande Voorde, Johan, Zhang, Qifeng, Chalmers, Susan, Sandison, Mairi E., Liu, Qin, Hedley, Ann, McBryan, Tony, Tang, Hsin-Yao, Gorman, Nicole, Beer, Thomas, Speicher, David W., Adams, Peter D., Liu, Xuefeng, Schlegel, Richard, McCarron, John G., Wakelam, Michael J. O., Gottlieb, Eyal, Kossenkov, Andrew V., Schug, Zachary T.

“…Background Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs),…”
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SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells by Wu, Shuai, Fatkhutdinov, Nail, Fukumoto, Takeshi, Bitler, Benjamin G., Park, Pyoung Hwa, Kossenkov, Andrew V., Trizzino, Marco, Tang, Hsin-Yao, Zhang, Lin, Gardini, Alessandro, Speicher, David W., Zhang, Rugang

“…Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo…”
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Forced Unfolding of Proteins Within Cells by Johnson, Colin P, Tang, Hsin-Yao, Carag, Christine, Speicher, David W, Discher, Dennis E

“…To identify cytoskeletal proteins that change conformation or assembly within stressed cells, in situ labeling of sterically shielded cysteines with…”
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The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis by Seo, Jae Ho, Rivadeneira, Dayana B, Caino, M Cecilia, Chae, Young Chan, Speicher, David W, Tang, Hsin-Yao, Vaira, Valentina, Bosari, Silvano, Palleschi, Alessandro, Rampini, Paolo, Kossenkov, Andrew V, Languino, Lucia R, Altieri, Dario C

“…Mitochondria must buffer the risk of proteotoxic stress to preserve bioenergetics, but the role of these mechanisms in disease is poorly understood. Using a…”
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Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase by Dheekollu, Jayaraju, Wiedmer, Andreas, Soldan, Samantha S, Castro-Muñoz, Leonardo Josué, Chen, Christopher, Tang, Hsin-Yao, Speicher, David W, Lieberman, Paul M

“…Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is causally associated with various malignancies and autoimmune disease. Epstein-Barr Nuclear…”
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Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits by Ghosh, Jagadish C., Seo, Jae Ho, Agarwal, Ekta, Wang, Yuan, Kossenkov, Andrew V., Tang, Hsin-Yao, Speicher, David W., Altieri, Dario C.

“…Tumor mitochondria have heightened protein folding quality control, but the regulators of this process and how they impact cancer traits are not completely…”
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Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress by Shytaj, Iart Luca, Procopio, Francesco Andrea, Tarek, Mohammad, Carlon‐Andres, Irene, Tang, Hsin‐Yao, Goldman, Aaron R, Munshi, MohamedHusen, Kumar Pal, Virender, Forcato, Mattia, Sreeram, Sheetal, Leskov, Konstantin, Ye, Fengchun, Lucic, Bojana, Cruz, Nicolly, Ndhlovu, Lishomwa C, Bicciato, Silvio, Padilla‐Parra, Sergi, Diaz, Ricardo Sobhie, Singh, Amit, Lusic, Marina, Karn, Jonathan, Alvarez‐Carbonell, David, Savarino, Andrea

“…HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir responsible for maintaining lifelong infection. Glycolytic metabolism…”
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A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism by Lamontagne, R Jason, Soldan, Samantha S, Su, Chenhe, Wiedmer, Andreas, Won, Kyoung Jae, Lu, Fang, Goldman, Aaron R, Wickramasinghe, Jayamanna, Tang, Hsin-Yao, Speicher, David W, Showe, Louise, Kossenkov, Andrew V, Lieberman, Paul M

“…Epstein-Barr virus (EBV) immortalizes resting B-lymphocytes through a highly orchestrated reprogramming of host chromatin structure, transcription and…”
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Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements by Seo, Jae Ho, Agarwal, Ekta, Bryant, Kelly G, Caino, M Cecilia, Kim, Eui Tae, Kossenkov, Andrew V, Tang, Hsin-Yao, Languino, Lucia R, Gabrilovich, Dmitry I, Cohen, Andrew R, Speicher, David W, Altieri, Dario C

“…Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their accumulation at the cortical cytoskeleton and limiting the…”
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MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer by Seo, Jae Ho, Chae, Young Chan, Kossenkov, Andrew V, Lee, Yu Geon, Tang, Hsin-Yao, Agarwal, Ekta, Gabrilovich, Dmitry I, Languino, Lucia R, Speicher, David W, Shastrula, Prashanth K, Storaci, Alessandra Maria, Ferrero, Stefano, Gaudioso, Gabriella, Caroli, Manuela, Tosi, Davide, Giroda, Massimo, Vaira, Valentina, Rebecca, Vito W, Herlyn, Meenhard, Xiao, Min, Fingerman, Dylan, Martorella, Alessandra, Skordalakes, Emmanuel, Altieri, Dario C

“…The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms…”
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Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity by Zhang, Xue, Pant, Shishir M., Ritch, Cecily C., Tang, Hsin-Yao, Shao, Hongguang, Dweep, Harsh, Gong, Yao-Yu, Brooks, Rebekah, Brafford, Patricia, Wolpaw, Adam J., Lee, Yool, Weeraratna, Ashani, Sehgal, Amita, Herlyn, Meenhard, Kossenkov, Andrew, Speicher, David, Sorger, Peter K., Santagata, Sandro, Dang, Chi V.

“…The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role…”
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Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma by Echan, Lynn A., Tang, Hsin-Yao, Ali-Khan, Nadeem, Lee, KiBeom, Speicher, David W.

“…Systematic detection of low‐abundance proteins in human blood that may be putative disease biomarkers is complicated by an extremely wide range of protein…”
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