Search Results - "Tanen, Michael"

Quantification of tau in cerebrospinal fluid by immunoaffinity enrichment and tandem mass spectrometry by McAvoy, Thomas, Lassman, Michael E, Spellman, Daniel S, Ke, Zhenlian, Howell, Bonnie J, Wong, Oitak, Zhu, Lan, Tanen, Michael, Struyk, Arie, Laterza, Omar F

“…Cerebrospinal fluid (CSF) tau is a common biomarker for Alzheimer disease (AD). Measurements of tau have historically been performed using immunoassays. Given…”
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Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort by Seeburger, Jeffrey L, Holder, Daniel J, Combrinck, Marc, Joachim, Catharine, Laterza, Omar, Tanen, Michael, Dallob, Aimee, Chappell, Derek, Snyder, Karen, Flynn, Mary, Simon, Adam, Modur, Vijay, Potter, William Z, Wilcock, Gordon, Savage, Mary J, Smith, A David

“…Cerebrospinal fluid (CSF) amyloid-β (Aβ) and tau have been studied as markers of Alzheimer's disease (AD). Combined Aβ42 and t-tau distinguishes AD from…”
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Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: A double-blind, randomized, placebo-controlled study in healthy male volunteers by Bergman, Arthur J., Stevens, Catherine, Zhou, YanYan, Yi, Bingming, Laethem, Martine, De Smet, Marina, Snyder, Karen, Hilliard, Deborah, Tanaka, Wesley, Zeng, Wei, Tanen, Michael, Wang, Amy Q., Chen, Li, Winchell, Gregory, Davies, Michael J., Ramael, Steven, Wagner, John A., Herman, Gary A.

“…Dipeptidyl peptidase-IV (DPP-IV) inhibitorsrepresent a new class of oral antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV…”
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Pharmacokinetics and Pharmacodynamic Effects of the Oral DPP-4 Inhibitor Sitagliptin in Middle-Aged Obese Subjects by Herman, Gary A., Bergman, Arthur, Liu, Fang, Stevens, Cathy, Wang, Amy Q., Zeng, Wei, Chen, Li, Snyder, Karen, Hilliard, Deborah, Tanen, Michael, Tanaka, Wesley, Meehan, Alan G., Lasseter, Kenneth, Dilzer, Stacy, Blum, Robert, Wagner, John A.

“…Sitagliptin (MK‐0431) is an oral, potent, and selective dipeptidyl peptidase‐IV (DPP‐4) inhibitor developed for the treatment of type 2 diabetes. This…”
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Distinct Properties and Advantages of a Novel Peroxisome Proliferator-Activated Protein γ Selective Modulator by Berger, Joel P, Petro, Ann E, Macnaul, Karen L, Kelly, Linda J, Zhang, Bei B, Richards, Karen, Elbrecht, Alex, Johnson, Bruce A, Zhou, Gaochao, Doebber, Thomas W, Biswas, Chhabi, Parikh, Mona, Sharma, Neelam, Tanen, Michael R, Thompson, G. Marie, Ventre, John, Adams, Alan D, Mosley, Ralph, Surwit, Richard S, Moller, David E

“…Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to serve as agonists of the peroxisome proliferator-activated receptor γ (PPARγ)…”
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High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples by REISER, Vladimir, SMITH, Ryan C, TANEN, Michael R, LAZAR, Gloria, ZIEBA, Renata, ICHETOVKIN, Marina, ZHU CHEN, O'NEILL, Edward A, TANAKA, Wesley K, MARTON, Matthew J, JASON LIAO, MORRIS, Mark, JIYAN XUE, HAILMAN, Eric, TOKIWA, George Y, PLUMP, Andrew S, KURTZ, Marc M, RONG LIU, LEGRAND, Cheryl, XUANMIN HE, XIANG YU, PEGGY WONG, HINCHCLIFFE, John S

“…With expanding biomarker discovery efforts and increasing costs of drug development, it is critical to maximize the value of mass-limited clinical samples. The…”
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Kinetics of TH2 biomarkers in sputum of asthmatics following inhaled allergen by Zuiker, Rob G. J. A., Ruddy, Marcella K., Morelli, Nicoletta, Mogg, Robin, Rivas, Veronica M., van Dyck, Kristien, De Lepeleire, Inge, Tanen, Michael R. L., Boot, J. Diderik, Kamerling, Ingrid M. C., Diamant, Zuzana

“…Allergen-induced late airway response offers important pharmacodynamic targets, including T helper 2 (TH2) biomarkers. However, detection of inflammatory…”
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Analysis of the Functional Role of Steroid Receptor Coactivator-1 in Ligand-Induced Transactivation by Thyroid Hormone Receptor by Jeyakumar, M, Tanen, Michael R, Bagchi, Milan K

“…The nuclear hormone receptors belonging to the steroid/thyroid/retinoid receptor superfamily are ligand-inducible transcription factors. These receptors…”
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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients by Kennedy, Matthew E, Stamford, Andrew W, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Dockendorf, Marissa F, Egan, Michael, Ereshefsky, Larry, Hodgson, Robert A, Hyde, Lynn A, Jhee, Stanford, Kleijn, Huub J, Kuvelkar, Reshma, Li, Wei, Mattson, Britta A, Mei, Hong, Palcza, John, Scott, Jack D, Tanen, Michael, Troyer, Matthew D, Tseng, Jack L, Stone, Julie A, Parker, Eric M, Forman, Mark S

“…β-Amyloid (Aβ) peptides are thought to be critically involved in the etiology of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor…”
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Pharmacokinetics and Pharmacodynamics of the BACE1 Inhibitor Verubecestat (MK‐8931) in Healthy Japanese Adults: A Randomized, Placebo‐Controlled Study by Chris Min, K., Dockendorf, Marissa F., Palcza, John, Tseng, Jack, Ma, Lei, Stone, Julie A., Kleijn, Huub J., Hodsman, Peter, Masuo, Kazuko, Tanen, Michael, Troyer, Matthew D., Vugt, Marianne, Forman, Mark S.

“…β‐site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for the production of β‐amyloid (Aβ) peptides and is considered a potential treatment…”
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Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes by Herman, Gary A., Bergman, Arthur, Stevens, Catherine, Kotey, Paul, Yi, Bingming, Zhao, Peng, Dietrich, Bruno, Golor, George, Schrodter, Andreas, Keymeulen, Bart, Lasseter, Kenneth C., Kipnes, Mark S., Snyder, Karen, Hilliard, Deborah, Tanen, Michael, Cilissen, Caroline, De Smet, Marina, de Lepeleire, Inge, Van Dyck, Kristien, Wang, Amy Q., Zeng, Wei, Davies, Michael J., Tanaka, Wesley, Holst, Jens J., Deacon, Carolyn F., Gottesdiener, Keith M., Wagner, John A.

“…Context: In response to a meal, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are released and modulate glycemic control…”
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Pharmacokinetics and Pharmacodynamics of the BACE 1 Inhibitor Verubecestat ( MK ‐8931) in Healthy Japanese Adults: A Randomized, Placebo‐Controlled Study by Chris Min, K., Dockendorf, Marissa F., Palcza, John, Tseng, Jack, Ma, Lei, Stone, Julie A., Kleijn, Huub J., Hodsman, Peter, Masuo, Kazuko, Tanen, Michael, Troyer, Matthew D., van Vugt, Marianne, Forman, Mark S.

“…β‐site amyloid precursor protein cleaving enzyme 1 (BACE 1) is required for the production of β‐amyloid (Aβ) peptides and is considered a potential treatment…”
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Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses by Herman, Gary A, Stevens, Cathy, Van Dyck, Kristien, Bergman, Arthur, Yi, Bingming, De Smet, Marina, Snyder, Karen, Hilliard, Deborah, Tanen, Michael, Tanaka, Wesley, Wang, Amy Q, Zeng, Wei, Musson, Donald, Winchell, Gregory, Davies, Michael J, Ramael, Steven, Gottesdiener, Keith M, Wagner, John A

“…Background Sitagliptin (MK‐0431 [(2R)‐4‐oxo‐4‐(3‐[trifluoromethyl]‐5,6‐dihydro[1,2,4]triazolo[4,3‐a]pyrazin‐7[8H]‐yl)‐1‐(2,4,5‐trifluorophenyl)butan‐2‐amine])…”
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Nonspecific binding of Aβ42 to polypropylene tubes and the effect of Tween-20 by Pica-Mendez, Arnaldo M., Tanen, Michael, Dallob, Aimee, Tanaka, Wesley, Laterza, Omar F.

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Next Generation Ligand Binding Assays—Review of Emerging Real-Time Measurement Technologies by Fraser, Stephanie, Cameron, Mark, O’Connor, Edward, Schwickart, Martin, Tanen, Michael, Ware, Mark

“…ABSTRACT Over the last few years, numerous ligand binding assay technologies that utilize real-time measurement have been introduced; however, an assemblage…”
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ACUTE ADMINISTRATION OF A BACE INHIBITOR IN HEALTHY HUMANS RESULTS IN A SIGNIFICANT REDUCTION OF Aβ OLIGOMERS IN CEREBROSPINAL FLUID by Kalinina, Juliya, Cheon, Kyeongmi, Stone, Julie, Kennedy, Matthew, Forman, Mark, Egan, Michael F., Tanen, Michael R., Winrow, Christopher J., Savage, Mary J.

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Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization by Combs, Terry P, Wagner, John A, Berger, Joel, Doebber, Tom, Wang, Wen-Jun, Zhang, Bei B, Tanen, Michael, Berg, Anders H, O’Rahilly, Stephen, Savage, David B, Chatterjee, Krishna, Weiss, Stuart, Larson, Patrick J, Gottesdiener, Keith M, Gertz, Barry J, Charron, Maureen J, Scherer, Philipp E, Moller, David E

“…Adipocyte complement-related protein of 30 kDa (Acrp30, adiponectin, or AdipoQ) is a fat-derived secreted protein that circulates in plasma. Adipose tissue…”
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Evaluation of Urinary Renal Biomarkers for Early Prediction of Acute Kidney Injury Following Partial Nephrectomy: A Feasibility Study by Lane, Brian R., Babitz, Stephen K., Vlasakova, Katerina, Wong, Allen, Noyes, Sabrina L., Boshoven, William, Grady, Pam, Zimmerman, Cindy, Engerman, Susan, Gebben, Maureen, Tanen, Michael, Glaab, Warren E., Sistare, Frank D.

“…Partial nephrectomy (PN) is the gold standard for the treatment of small renal masses. Urinary biomarkers (UBMs) may serve as early indicators of acute kidney…”
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Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity by Berger, Joel, Tanen, Michael, Elbrecht, Alex, Hermanowski-Vosatka, Anne, Moller, David E., Wright, Samuel D., Thieringer, Rolf

“…Peroxisome proliferator-activated receptor- gamma (PPAR gamma ) has been shown to play an important role in the regulation of expression of a subclass of…”
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P4‐241: Performance characteristics of the luminex® xmap® tau/amyloid ß(42) assay for determination of tau/amyloid ß(42) ratio measurements in cerebrospinal fluid (CSF) by Weiss, Christy, Cowes, Arturo, Bush, Michele M., Surls, Jacqueline, DeSilva, Ganga, Sagini, Eileen M., Tanen, Michael, Laterza, Omar, Altman, Amy, Bridge-Cook, Jeremy

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