Octenidine in root canal and dentine disinfection ex vivo

Aim The aim of the present study was to investigate the antimicrobial activity of octenidine on Enterococcus faecalis ATCC 29212 in a dentine block model. Methodology Fifty‐six root segments of extracted human teeth were infected with E. faecalis for 4 weeks. Octenidine‐phenoxyethanol gel (1 : 1)...

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Bibliographic Details
Published in:	International endodontic journal Vol. 40; no. 11; pp. 845 - 851
Main Authors:	Tandjung, L., Waltimo, T., Hauser, I., Heide, P., Decker, E.-M., Weiger, R.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-11-2007
Subjects:	Anti-Infective Agents, Local - pharmacology Colony Count, Microbial Dentin - microbiology dentine disinfection Dentistry Enterococcus faecalis Enterococcus faecalis - drug effects Humans octenidine Pyridines - pharmacology root canal dressing Root Canal Irrigants - pharmacology
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Summary:	Aim The aim of the present study was to investigate the antimicrobial activity of octenidine on Enterococcus faecalis ATCC 29212 in a dentine block model. Methodology Fifty‐six root segments of extracted human teeth were infected with E. faecalis for 4 weeks. Octenidine‐phenoxyethanol gel (1 : 1) was applied for different timing: 1 min, 10 min, 7 days and in a different formula (1 : 3) for 10 min. Three samples were chosen for the group with placebo gel and for the group without infection (negative control). Dentine samples were collected, and the total count of bacteria and colony‐forming units were determined. In addition, for controls and the 10 min group with 1 : 1 gel, the proportion of viable bacteria (PVB) was assessed. Results Octenidine was particularly effective after incubation periods of 10 min and 7 days. The mean PVB decreased significantly from 57.2% to 5.7% after 10 min application. After 7 days, only one of 10 samples showed positive culture. Conclusion The present study showed the effectiveness of octenidine against E. faecalis in dentine disinfection. Further laboratory and clinical studies are required.
Bibliography:	ark:/67375/WNG-V44W9NXJ-P ArticleID:IEJ1279 istex:0A224DBD70238CE89FAC6380D029A73CDB837416 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0143-2885 1365-2591
DOI:	10.1111/j.1365-2591.2007.01279.x