Search Results - "Tandeske, Laura"

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance by Shaqra, Ala M., Zvornicanin, Sarah N., Huang, Qiu Yu J., Lockbaum, Gordon J., Knapp, Mark, Tandeske, Laura, Bakan, David T., Flynn, Julia, Bolon, Daniel N. A., Moquin, Stephanie, Dovala, Dustin, Kurt Yilmaz, Nese, Schiffer, Celia A.

“…Coronaviruses can evolve and spread rapidly to cause severe disease morbidity and mortality, as exemplified by SARS-CoV-2 variants of the COVID-19 pandemic…”
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RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation by Holderfield, Matthew, Merritt, Hanne, Chan, John, Wallroth, Marco, Tandeske, Laura, Zhai, Huili, Tellew, John, Hardy, Stephen, Hekmat-Nejad, Mohammad, Stuart, Darrin D., McCormick, Frank, Nagel, Tobi E.

“…ATP competitive inhibitors of the BRAFV600E oncogene paradoxically activate downstream signaling in cells bearing wild-type BRAF (BRAFWT). In this study, we…”
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Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon by Ma, Xiaolei, Leon, Barbara, Ornelas, Elizabeth, Dovala, Dustin, Tandeske, Laura, Luu, Catherine, Pardee, Gwynn, Widger, Stephania, Solomon, Jonathan M., Beckwith, Rohan E. J., Moser, Heinz, Clifton, Matthew C., Wartchow, Charles A.

“…The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired protein while excluding teratogenic SALL4 is an area of significant…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Inhibition of prenylated KRAS in a lipid environment by Jansen, Johanna M, Wartchow, Charles, Jahnke, Wolfgang, Fong, Susan, Tsang, Tiffany, Pfister, Keith, Zavorotinskaya, Tatiana, Bussiere, Dirksen, Cheng, Jan Marie, Crawford, Kenneth, Dai, Yumin, Dove, Jeffrey, Fang, Eric, Feng, Yun, Florent, Jean-Michel, Fuller, John, Gossert, Alvar D, Hekmat-Nejad, Mohammad, Henry, Chrystèle, Klopp, Julia, Lenahan, William P, Lingel, Andreas, Ma, Sylvia, Meyer, Arndt, Mishina, Yuji, Narberes, Jamie, Pardee, Gwynn, Ramurthy, Savithri, Rieffel, Sebastien, Stuart, Darrin, Subramanian, Sharadha, Tandeske, Laura, Widger, Stephania, Widmer, Armin, Winterhalter, Aurelie, Zaror, Isabel, Hardy, Stephen

“…RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a…”
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Design of Novel Conformational and Genotype-Specific Antigens for Improving Sensitivity of Immunoassays for Hepatitis C Virus-Specific Antibodies by Lin, Sansan, Arcangel, Phillip, Medina-Selby, Angelica, Coit, Doris, Ng, Philip, Nguyen, Steve, McCoin, Colin, Gyenes, Alex, Hu, Celine, Tandeske, Laura, Phelps, Bruce, Chien, David

“…The current commercially licensed enzyme-linked immunosorbent assays (ELISAs) for hepatitis C virus (HCV) mainly use recombinant proteins containing linear…”
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Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness by Barkan, David T., Garland, Keira, Zhang, Lei, Eastman, Richard T., Hesse, Matthew, Knapp, Mark, Ornelas, Elizabeth, Tang, Jenny, Cortopassi, Wilian Augusto, Wang, Yu, King, Frederick, Jia, Weiping, Nguyen, Zachary, Frank, Andreas O., Chan, Ryan, Fang, Eric, Fuller, Daniel, Busby, Scott, Carias, Heidi, Donahue, Kristine, Tandeske, Laura, Diagana, Thierry T., Jarrousse, Nadine, Moser, Heinz, Sarko, Christopher, Dovala, Dustin, Moquin, Stephanie, Marx, Vanessa M.

“…The COVID-19 pandemic highlights the ongoing risk of zoonotic transmission of coronaviruses to global health. To prepare for future pandemics, it is essential…”
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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes by Pinch, Benika J, Buckley, Dennis L, Gleim, Scott, Brittain, Scott M, Tandeske, Laura, D'Alessandro, Pier Luca, Hauseman, Zachary J, Lipps, Jennifer, Xu, Lei, Harvey, Edward P, Schirle, Markus, Sprague, Elizabeth R, Forrester, William C, Dovala, Dustin, McGregor, Lynn M, Thoma, Claudio R

“…While there are hundreds of predicted E3 ligases, characterizing their applications for targeted protein degradation has proved challenging. Here, we report a…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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Discovery of Potent Pyrazoline‐Based Covalent SARS‐CoV‐2 Main Protease Inhibitors by Moon, Patrick, Zammit, Charlotte M., Shao, Qian, Dovala, Dustin, Boike, Lydia, Henning, Nathaniel J., Knapp, Mark, Spradlin, Jessica N., Ward, Carl C., Wolleb, Helene, Fuller, Daniel, Blake, Gabrielle, Murphy, Jason P., Wang, Feng, Lu, Yipin, Moquin, Stephanie A., Tandeske, Laura, Hesse, Matthew J., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Toste, F. Dean, Nomura, Daniel K.

“…While vaccines and antivirals are now being deployed for the current SARS‐CoV‐2 pandemic, we require additional antiviral therapeutics to not only effectively…”
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Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors by Smith, Aaron, Ni, Zhi-Jie, Poon, Daniel, Huang, Zilin, Chen, Zheng, Zhang, Qiong, Tandeske, Laura, Merritt, Hanne, Shoemaker, Kevin, Chan, John, Kaufman, Susan, Huh, Kay, Murray, Jeremy, Appleton, Brent A., Cowan-Jacob, Sandra W., Scheufler, Clemens, Kanazawa, Takanori, Jansen, Johanna M., Stuart, Darrin, Shafer, Cynthia M.

“…A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs were designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the…”
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Abstract LB-28: RAF inhibitors activate MAPK pathway through relief of RAF auto-inhibition by Holderfield, Matthew, Merritt, Hanne, Chan, John, Wallroth, Marco, Tandeske, Laura, Hardy, Steve, Hekmat-Nejad, Mohammad, McCormick, Frank, Nagel, Tobi

“…Abstract Mutations in the RAS/RAF/MEK/ERK pathway are among the most common in human cancers, and RAF small molecule kinase inhibitors are now being tested for…”
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Abstract B38: Inhibiting mutated KRAS, a broken switch of effector pathways by Jansen, Johanna, Jahnke, Wolfgang, Fong, Susan, Tandeske, Laura, Wartchow, Charles, Pfister, Keith, Zavorotinskaya, Tatiana, Blechschmidt, Anke, Bussiere, Dirksen, Dai, Yumin, Dove, Jeff, Fang, Eric, Farley, David, Florent, Jean-Michel, Fuller, John, Gokhin, Simona, Gossert, Alvar, Hekmat-Nejad, Mohammad, Henry, Chrystèle, Klopp, Julia, Lenahan, Bill, Lingel, Andreas, Meyer, Arndt, Narberes, Jamie, Pardee, Gwynn, Paris, C Gregory, Ramurthy, Savithri, Renhowe, Paul, Rieffel, Sebastien, Shoemaker, Kevin, Subramanian, Sharadha, Tsang, Tiffany, Widger, Stephania, Widmer, Armin, Zaror, Isabel, Hardy, Stephen

“…Abstract Mutated forms of KRAS are no longer able to switch effectors between “on” and “off” states. It is known that the function of KRAS is controlled by key…”
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Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses by Vajdy, Michael, Selby, Mark, Medina-Selby, Angelica, Coit, Doris, Hall, John, Tandeske, Laura, Chien, David, Hu, Celine, Rosa, Domenico, Singh, Manmohan, Kazzaz, Jina, Nguyen, Steve, Coates, Steve, Ng, Philip, Abrignani, Sergio, Lin, Yin-Ling, Houghton, Michael, O'Hagan, Derek T

“…1 Chiron Vaccines, 4560 Horton Street, Emeryville, CA 94608, USA 2 Chiron Vaccines, Via Fiorentina 1, 53100 Siena, Italy Correspondence Michael Houghton…”
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