Search Results - "Tande, P M"

Effects of temperature on cycle length dependent changes and restitution of action potential duration in guinea pig ventricular muscle by Bjørnstad, H, Tande, P M, Lathrop, D A, Refsum, H

“…The aim was to investigate the effects of temperature on cycle length dependent changes of action potential duration and on restitution of action potential…”
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Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium by Tande, P M, Bjørnstad, H, Yang, T, Refsum, H

“…The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in…”
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Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes by Yang, T, Tande, P M, Lathrop, D A, Refsum, H

“…The aim was to examine the electromechanical effects of dofetilide, a new class III antiarrhythmic agent, in isolated guinea pig ventricular muscle during…”
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Rate-dependent differences in dog epi- and endocardial monophasic action potential configuration in vivo by Tande, P M, Mortensen, E, Refsum, H

“…A transient outward current (Ito), long considered to be a unique feature of Purkinje fiber tissue, has recently been demonstrated in dog ventricular tissue in…”
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Negative chronotropic effect of a novel class III antiarrhythmic drug, UK‐68,798, devoid of β‐blocking action on isolated guinea‐pig atria by Yang, Tao, Tande, Pål M., Refsum, Helge

“…1 The chronotropic effects of a novel class III antiarrhythmic drug, UK‐68,798, and the β‐adrenoceptor blocker, propranolol, for comparison, were studied on…”
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Mechanism of ECG changes and arrhythmogenic properties of low osmolality contrast media during coronary arteriography in dog by Kløw, N E, Tande, P M, Hevrøy, O, Refsum, H

“…The aim of the study was to investigate the mechanisms behind ECG changes and ventricular arrhythmias during coronary arteriography. Transmembrane action…”
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Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle by TAO YANG, TANDE, P. M, LATHROP, D. A, REFSUM, H

“…The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a…”
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Mechanisms for hypothermia-induced increase in contractile force studied by mechanical restitution and post-rest contractions in guinea-pig papillary muscle by Bjørnstad, H, Tande, P M, Refsum, H

“…Lowering myocardial temperature increases contractile force, presumably by increasing intracellular calcium content. To study the mechanisms behind this, we…”
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Electromechanical action of dofetilide and D-sotalol during simulated metabolic acidosis in isolated guinea pig ventricular muscle by Yang, T, Tande, P M, Refsum, H

“…We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular…”
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Positive inotropy linked with class III antiarrhythmic action: electrophysiological effects of the cardiotonic agent DPI 201-106 in the dog heart in vivo by Mortensen, E, Tande, P M, Kløw, N E, Platou, E S, Refsum, H

“…The aim was to investigate whether the positive inotrope DPI 201-106 prolongs ventricular monophasic action potential duration and refractoriness in vivo…”
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Class III antiarrhythmic action of d-sotalol during hypothermia by Bjørnstad, H, Tande, P M, Refsum, H

“…To investigate whether changes in temperature influence the electrophysiologic effects of the class III antiarrhythmic agent d-sotalol, we studied its effects…”
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Hemodynamic effects of d-sotalol in acute ischemic heart failure in dogs by Mortensen, E, Tande, P M, Kløw, N E, Refsum, H

“…This study was designed to determine the hemodynamic effects of the class III antiarrhythmic agent d-sotalol in acute ischemic heart failure at concentrations…”
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Selenium deficiency and cardiac electrophysiological and mechanical function in the rat by Ringstad, J, Tande, P M, Norheim, G, Refsum, H

“…Earlier studies have shown that selenium and vitamin E are important in maintaining normal cardiac function. The present study was designed to test the effect…”
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Cardiac electrophysiology during hypothermia. Implications for medical treatment by Bjørnstad, H, Tande, P M, Refsum, H

“…Reduction in body temperature induces characteristic electrophysiological and mechanical alterations of the heart. The heart rate is markedly reduced…”
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Class III antiarrhythmic action linked with positive inotropy: acute electrophysiological and inotropic effects of amiodarone in vitro by Tande, P M, Refsum, H

“…Negative inotropy is an adverse feature of most antiarrhythmic drugs. Positive inotropy, however, has been demonstrated for some drugs with class III…”
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Plasma concentrations and haemodynamic effects of d-sotalol after beta-blockade in dogs by Mortensen, E, Tande, P M, Kløw, N E, Refsum, H

“…This study was designed to investigate the haemodynamic effects of d-sotalol at plasma concentrations producing class III antiarrhythmic effects. d-Sotalol 1,…”
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Class III antiarrhythmic action linked with positive inotropy: effects of the d- and l-isomer of sotalol on isolated rat atria at threshold and suprathreshold stimulation by Tande, P M, Refsum, H

“…The beta-adrenoceptor blocker sotalol has been shown to possess class III antiarrhythmic action. The present study was designed to test the hypothesis that…”
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Accidental hypothermia by Bjørnstad, H, Tande, P M, Refsum, H

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Electromechanical effects of two low osmolality contrast media, ioxaglate and iohexol, on isolated rat atria by Tande, P M, Kløw, N E, Refsum, H

“…This study aimed at investigating the direct effects of two low osmolality radiographic contrast media, iohexol (non-ionic) and ioxaglate (ionic), on…”
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