Serum 25-Hydroxyvitamin D Level Is Associated With Arterial Stiffness, Left Ventricle Hypertrophy, and Inflammation in Newly Diagnosed Hypertension

ObjectivesVitamin D may modulate vascular inflammation, vascular smooth muscle cell proliferation, the renin-angiotensin system, and cardiomyocyte proliferation, myocardial fibrosis, and proliferation. These mechanisms may play a role on arterial stiffness and left ventricle hypertrophy (LVH) in hyp...

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Published in:	Journal of investigative medicine Vol. 61; no. 6; pp. 989 - 994
Main Authors:	Kuloğlu, Osman, Gür, Mustafa, eker, Taner, Kalkan, Gülhan Yüksel, ahin, Durmuş Yıldıray, Tanboğa, brahim Halil, Koyunsever, Nermin Yıldız, Harbalıoğlu, Hazar, Türkoğlu, Caner, Akyol, Selahattin, Elbasan, Zafer, Acele, Armağan, Çaylı, Murat
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-08-2013 Sage Publications Ltd
Subjects:	Aged Biomarkers - blood Female Humans Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - diagnosis Hypertrophy, Left Ventricular - epidemiology Inflammation - blood Inflammation - diagnosis Inflammation - epidemiology Male Middle Aged Vascular Stiffness - physiology Vitamin D - analogs & derivatives Vitamin D - blood aortic stiffness pulse wave velocity hypertension vitamin D
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Summary:	ObjectivesVitamin D may modulate vascular inflammation, vascular smooth muscle cell proliferation, the renin-angiotensin system, and cardiomyocyte proliferation, myocardial fibrosis, and proliferation. These mechanisms may play a role on arterial stiffness and left ventricle hypertrophy (LVH) in hypertensive patients. We aimed to evaluate the association between serum vitamin D with arterial stiffness and LVH in patients with hypertension.MethodsWe studied 133 patients with newly diagnosed hypertension [mean (SD) age, 62.9 (10.6) years]. Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph ARCsolver algorithm. Left ventricular mass index (LVMI) was determined according to Deverux formula. The patients were divided into the following 2 groups according to serum vitamin D level: vitamin Dlow group with less than 20 ng/mL and vitamin Dhigh group with greater than or equal to 20 ng/mL.ResultsThe highest PWV, high-sensitivity C reactive protein, and LVMI values were observed in vitamin Dlow group compared with vitamin Dhigh group. Multiple linear regression analysis showed that vitamin D level was independently associated with LVMI (β = −0.235, P = 0.002) and PWV (β = −0.432, P < 0.001). Adjustment for age, sex, parathyroid hormone level, body surface area, and mean blood pressure did not modify these associations. Vitamin D level was also independently associated with high-sensitivity C reactive protein (β = −0.143, P = 0.047). However, adjustment for parathyroid hormone level or body surface area and mean blood pressure attenuate this association.ConclusionsSerum 25-hyroxyvitamin D is independently related with arterial stiffness, LVH, and inflammation. Vitamin D may play a role on pathogenesis of arterial stiffness and LVH in patient with newly diagnosed hypertension.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1081-5589 1708-8267
DOI:	10.2310/JIM.0b013e31829a82bc