Search Results - "Tanaka, Tomoyuki U"

Kinetochore-microtubule interactions: steps towards bi-orientation by Tanaka, Tomoyuki U

“…Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis, which is necessary for maintenance of their genetic integrity. This…”
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Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment by Natsume, Toyoaki, Müller, Carolin A., Katou, Yuki, Retkute, Renata, Gierliński, Marek, Araki, Hiroyuki, Blow, J. Julian, Shirahige, Katsuhiko, Nieduszynski, Conrad A., Tanaka, Tomoyuki U.

“…Centromeres play several important roles in ensuring proper chromosome segregation. Not only do they promote kinetochore assembly for microtubule attachment,…”
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Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast by García-Rodríguez, Luis J., Kasciukovic, Taciana, Denninger, Viola, Tanaka, Tomoyuki U.

“…For proper chromosome segregation in mitosis, sister kinetochores must interact with microtubules from opposite spindle poles (chromosome bi-orientation) [1,…”
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Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase by Li, Shuyu, Yue, Zuojun, Tanaka, Tomoyuki U.

“…Cohesins establish sister chromatid cohesion during S phase and are removed when cohesin Scc1 is cleaved by separase at anaphase onset. During this process,…”
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Kinetochore–microtubule error correction is driven by differentially regulated interaction modes by Kalantzaki, Maria, Kitamura, Etsushi, Zhang, Tongli, Mino, Akihisa, Novák, Béla, Tanaka, Tomoyuki U.

“…For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish…”
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Kinetochore–microtubule interactions: the means to the end by Tanaka, Tomoyuki U, Desai, Arshad

“…Kinetochores are proteinaceous complexes containing dozens of components; they are assembled at centromeric DNA regions and provide the major microtubule…”
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SWAP, SWITCH, and STABILIZE: Mechanisms of Kinetochore-Microtubule Error Correction by Tanaka, Tomoyuki U, Zhang, Tongli

“…For correct chromosome segregation in mitosis, eukaryotic cells must establish chromosome biorientation where sister kinetochores attach to microtubules…”
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Molecular Mechanisms of Microtubule-Dependent Kinetochore Transport toward Spindle Poles by Tanaka, Kozo, Kitamura, Etsushi, Kitamura, Yoko, Tanaka, Tomoyuki U.

“…In mitosis, kinetochores are initially captured by the lateral sides of single microtubules and are subsequently transported toward spindle poles. Mechanisms…”
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Live-Cell Imaging Reveals Replication of Individual Replicons in Eukaryotic Replication Factories by Kitamura, Etsushi, Blow, J. Julian, Tanaka, Tomoyuki U.

“…Faithful DNA replication ensures genetic integrity in eukaryotic cells, but it is still obscure how replication is organized in space and time within the…”
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Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis by Booth, Alexander Jr, Yue, Zuojun, Eykelenboom, John K, Stiff, Tom, Luxton, Gw Gant, Hochegger, Helfrid, Tanaka, Tomoyuki U

“…To ensure proper segregation during mitosis, chromosomes must be efficiently captured by spindle microtubules and subsequently aligned on the mitotic spindle…”
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High-Resolution Replication Profiles Define the Stochastic Nature of Genome Replication Initiation and Termination by Hawkins, Michelle, Retkute, Renata, Müller, Carolin A., Saner, Nazan, Tanaka, Tomoyuki U., de Moura, Alessandro P.S., Nieduszynski, Conrad A.

“…Eukaryotic genome replication is stochastic, and each cell uses a different cohort of replication origins. We demonstrate that interpreting high-resolution…”
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Discovery of an Unconventional Centromere in Budding Yeast Redefines Evolution of Point Centromeres by Kobayashi, Norihiko, Suzuki, Yutaka, Schoenfeld, Lori W., Müller, Carolin A., Nieduszynski, Conrad, Wolfe, Kenneth H., Tanaka, Tomoyuki U.

“…Centromeres are the chromosomal regions promoting kinetochore assembly for chromosome segregation. In many eukaryotes, the centromere consists of up to mega…”
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The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End by Maure, Jean-François, Komoto, Shinya, Oku, Yusuke, Mino, Akihisa, Pasqualato, Sebastiano, Natsume, Kayo, Clayton, Lesley, Musacchio, Andrea, Tanaka, Tomoyuki U.

“…Proper chromosome segregation in mitosis relies on correct kinetochore-microtubule (KT-MT) interactions. The KT initially interacts with the lateral surface of…”
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Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore by Bock, Lucy J., Pagliuca, Cinzia, Kobayashi, Norihiko, Grove, Ryan A., Oku, Yusuke, Shrestha, Kriti, Alfieri, Claudio, Golfieri, Cristina, Oldani, Amanda, Dal Maschio, Marianna, Bermejo, Rodrigo, Hazbun, Tony R., Tanaka, Tomoyuki U., De Wulf, Peter

“…Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and…”
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Stochastic association of neighboring replicons creates replication factories in budding yeast by Saner, Nazan, Karschau, Jens, Natsume, Toyoaki, Gierlinski, Marek, Retkute, Renata, Hawkins, Michelle, Nieduszynski, Conrad A, Blow, J Julian, de Moura, Alessandro P S, Tanaka, Tomoyuki U

“…Inside the nucleus, DNA replication is organized at discrete sites called replication factories, consisting of DNA polymerases and other replication proteins…”
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Mps1 Kinase Promotes Sister-Kinetochore Bi-orientation by a Tension-Dependent Mechanism by Maure, Jean-François, Kitamura, Etsushi, Tanaka, Tomoyuki U.

“…Segregation of sister chromatids to opposite spindle poles during anaphase is dependent on the prior capture of sister kinetochores by microtubules extending…”
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Molecular mechanisms of kinetochore capture by spindle microtubules by Tanaka, Tomoyuki U, Tanaka, Kozo, Mukae, Naomi, Dewar, Hilary, van Breugel, Mark, James, Euan K, Prescott, Alan R, Antony, Claude

“…For high-fidelity chromosome segregation, kinetochores must be properly captured by spindle microtubules, but the mechanisms underlying initial kinetochore…”
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Kinetochore-Dependent Microtubule Rescue Ensures Their Efficient and Sustained Interactions in Early Mitosis by Gandhi, Sapan R., Gierliński, Marek, Mino, Akihisa, Tanaka, Kozo, Kitamura, Etsushi, Clayton, Lesley, Tanaka, Tomoyuki U.

“…How kinetochores regulate microtubule dynamics to ensure proper kinetochore-microtubule interactions is unknown. Here, we studied this during early mitosis in…”
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Condensins Promote Chromosome Recoiling during Early Anaphase to Complete Sister Chromatid Separation by Renshaw, Matthew J., Ward, Jonathan J., Kanemaki, Masato, Natsume, Kayo, Nédélec, François J., Tanaka, Tomoyuki U.

“…Sister chromatid separation is initiated at anaphase onset by the activation of separase, which removes cohesins from chromosomes. However, it remains elusive…”
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The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4 by Gkikopoulos, Triantaffyllos, Singh, Vijender, Tsui, Kyle, Awad, Salma, Renshaw, Matthew J, Scholfield, Pieta, Barton, Geoffrey J, Nislow, Corey, Tanaka, Tomoyuki U, Owen-Hughes, Tom

“…In order to gain insight into the function of the Saccharomyces cerevisiae SWI/SNF complex, we have identified DNA sequences to which it is bound genomewide…”
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