Search Results - "Tanaka, R D"

Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep by Clark, J M, Abraham, W M, Fishman, C E, Forteza, R, Ahmed, A, Cortes, A, Warne, R L, Moore, W R, Tanaka, R D

“…Tryptase, a mast cell serine protease, has been implicated in the pathophysiology of allergic asthma, but formal evidence to support this hypothesis has been…”
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Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep by ELROD, K. C, MOORE, W. R, ABRAHAM, W. M, TANAKA, R. D

“…Tryptase, a serine protease released exclusively from activated mast cells, has been implicated as a potential causative agent in asthma. Enzymatically active…”
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Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways by Hinson, D D, Chambliss, K L, Toth, M J, Tanaka, R D, Gibson, K M

“…To assess the potential for feedback inhibition by isoprene intermediates in the cholesterol and nonsterol isoprene biosynthetic pathway, we expressed human…”
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Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway by CLARKE, C. F, TANAKA, R. D, SVENSON, K, WAMSLEY, M, FOGELMAN, A. M, EDWARDS, P. A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens by Mosley, S T, Kalinowski, S S, Schafer, B L, Tanaka, R D

“…Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the key enzyme that regulates cholesterol synthesis, lower serum cholesterol by…”
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Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria by Schafer, B L, Bishop, R W, Kratunis, V J, Kalinowski, S S, Mosley, S T, Gibson, K M, Tanaka, R D

“…Mevalonic aciduria is the first proposed inherited disorder of the cholesterol/isoprene biosynthetic pathway in humans, and it is presumed to be caused by a…”
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Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes by Edwards, P A, Lan, S F, Tanaka, R D, Fogelman, A M

“…3-Hydroxy-3-methylglutaryl(HMG)-coenzyme A reductase purified from rat liver in the absence of protease inhibitors is composed of two distinct polypeptides of…”
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Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin by Li, A C, Tanaka, R D, Callaway, K, Fogelman, A M, Edwards, P A

“…In the normal fed rat, both 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase and HMG-CoA reductase are found in high concentrations in hepatocytes that are…”
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Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A synthase and the chromosomal localization of the human gene by Mehrabian, M, Callaway, K A, Clarke, C F, Tanaka, R D, Greenspan, M, Lusis, A J, Sparkes, R S, Mohandas, T, Edmond, J, Fogelman, A M

“…3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase was purified to homogeneity from rat liver cytoplasm. The active enzyme is a dimer composed of…”
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Purification and regulation of mevalonate kinase from rat liver by TANAKA, R. D, SCHAFER, B. L, LEE, L. Y, FREUDENBERGER, J. S, MOSLEY, S. T

“…Mevalonate kinase may play a key role in regulating cholesterol biosynthesis because its activity may be regulated via feedback inhibition by intermediates in…”
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Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol by Tanaka, R D, Edwards, P A, Lan, S F, Fogelman, A M

“…25-Hydroxycholesterol inhibits cholesterol biosynthesis by inhibiting the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Addition of…”
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Mast cell tryptase: a new target for therapeutic intervention in asthma by Tanaka, R D, Clark, J M, Warne, R L, Abraham, W M, Moore, W R

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Mevalonate kinase is localized in rat liver peroxisomes by STAMELLOS, K. D, SHACKELFORD, J. E, TANAKA, R. D, KRISANS, S. K

“…Recent data suggest that rat liver peroxisomes play a critical role in cholesterol synthesis. Specifically, peroxisomes contain a number of enzymes required…”
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Nucleotide sequence of the rat low density lipoprotein receptor cDNA by LEE, L. Y, MOHLER, W. A, TANAKA, R. D, SCHAFER, B. L, FREUDENBERGER, J. S, BYRNE-CONNOLLY, N, EAGER, K. B, MOSLEY, S. T, LEIGHTON, J. K, THRIFT, R. N, DAVIS, R. A

“…A 4.7 kb cDNA clone ( lambda rLDL2-1a) coding for the rat low density lipoprotein (LDL) receptor was isolated from a lambda gt-11 rat liver cDNA library. The…”
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Inhibitors of tryptase for the treatment of mast cell-mediated diseases by Rice, K D, Tanaka, R D, Katz, B A, Numerof, R P, Moore, W R

“…Human tryptase is a structurally unique and mast cell specific trypsin-like serine protease. Recent biological and immunological investigations have implicated…”
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Effects of long-term administration of HMG-CoA reductase inhibitors on cholesterol synthesis in lens by Kalinowski, S S, Tanaka, R D, Mosley, S T

“…The effects of long-term dosing with inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase on the rate of cholesterol biosynthesis were…”
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Purification of cholesterol 7 alpha-hydroxylase from human and rat liver and production of inhibiting polyclonal antibodies by Nguyen, L B, Shefer, S, Salen, G, Ness, G, Tanaka, R D, Packin, V, Thomas, P, Shore, V, Batta, A

“…Cholesterol 7 alpha-hydroxylase, the cytochrome P-450-dependent and rate-controlling enzyme of bile acid synthesis, was purified from rat and human liver…”
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Inhibition of lysosomal protein degradation inhibits the basal degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by Tanaka, R D, Li, A C, Fogelman, A M, Edwards, P A

“…The effect of inhibiting lysosomal protein degradation on the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was determined using a…”
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Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A Reductase mRNA Levels in Rat Liver by Clarke, Catherine F., Edwards, Peter A., Lan, Show-Fung, Tanaka, Richard D., Fogelman, Alan M.

“…Addition of cholestyramine or cholestyramine plus mevinolin to the diet has been reported to increase the activity and mass of rat liver…”
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The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by Tanaka, R D, Edwards, P A, Lan, S F, Knöppel, E M, Fogelman, A M

“…Rats were fed powdered rat chow or a rat chow diet containing 5% cholestyramine or 5% cholestyramine with Mevinolin (112 mg/100 g food, 200 mg/kg body weight…”
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