Search Results - "Tanaka, Pearl"

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors by Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle

“…Polo-like kinase-2 (Plk-2) is a potential therapeutic target for Parkinson’s disease and this Letter describes the SAR of a series of dihydropteridinone based…”
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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors by Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Brigham, Elizabeth F., Chian, David, Franzini, Maurizio, Goldbach, Erich, Kwong, Grace T., Motter, Ruth, Probst, Gary D., Quinn, Kevin P., Ruslim, Lany, Sham, Hing L., Tam, Danny, Tanaka, Pearl, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with familial Parkinson’s disease (PD). The kinase activity of this complex protein is…”
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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch by Probst, Gary, Aubele, Danielle L., Bowers, Simeon, Dressen, Darren, Garofalo, Albert W., Hom, Roy K., Konradi, Andrei W., Marugg, Jennifer L., Mattson, Matthew N., Neitzel, Martin L., Semko, Chris M., Sham, Hing L., Smith, Jenifer, Sun, Minghua, Truong, Anh P., Ye, Xiaocong M., Xu, Ying-zi, Dappen, Michael S., Jagodzinski, Jacek J., Keim, Pamela S., Peterson, Brian, Latimer, Lee H., Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K., Quinn, Kevin P., Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F., Kholodenko, Dora, Hu, Kang, Kwong, Grace T., Lee, Michael, Liao, Anna, Motter, Ruth N., Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P., Hemphill, Susanna S., Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A., Basi, Guriqbal S.

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Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce [alpha]-Synuclein Phosphorylation in Rat Brain by Aubele, Danielle L, Hom, Roy K, Adler, Marc, Galemmo, Robert A, Bowers, Simeon, Truong, Anh P, Pan, Hu, Beroza, Paul, Neitz, R Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P, Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W, Latimer, Lee, Zhu, Yong L, Sham, Hing L, Anderson, John P, Bergeron, Marcelle, Artis, Dean R

“…Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of [alpha]-synuclein in Lewy bodies, which are one of the…”
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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch by Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S

“…Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We…”
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Selective and Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors That Reduce α-Synuclein Phosphorylation in Rat Brain by Aubele, Danielle L., Hom, Roy K., Adler, Marc, Galemmo Jr, Robert A., Bowers, Simeon, Truong, Anh P., Pan, Hu, Beroza, Paul, Neitz, R. Jeffrey, Yao, Nanhua, Lin, May, Tonn, George, Zhang, Heather, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Diep, Linnea, Fitzgerald, Kent, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Dappen, Michael, Jagodzinski, Jacek, Chan, Wayman, Konradi, Andrei W., Latimer, Lee, Zhu, Yong L., Sham, Hing L., Anderson, John P., Bergeron, Marcelle, Artis, Dean R.

“…Polo‐like kinase‐2 (Plk‐2) has been implicated as the dominant kinase involved in the phosphorylation of α‐synuclein in Lewy bodies, which are one of the…”
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P1‐029: A comparison of conventional versus push‐pull microdialysis for the detection of amyloid β in the mouse brain by Motter, Ruth, Veinbergs, Isaac, Cremers, Thomas, Van der Hart, Marieke, Yu, Lisa, Kooijker, Harm, Flik, Gunnar, Freije, Robert, Brendza, Robert, Tanaka, Pearl

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A comparison of conventional versus push-pull microdialysis for the detection of amyloid β in the mouse brain by Motter, Ruth, Veinbergs, Isaac, Cremers, Thomas, Van der Hart, Marieke, Yu, Lisa, Kooijker, Harm, Flik, Gunnar, Freije, Robert, Brendza, Robert, Tanaka, Pearl

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P3‐321: APP‐selective gamma secretase inhibitor ELND006 effects on brain parenchymal and vascular amyloid beta in the PDAPP mouse model of Alzheimer's disease by Schroeter, Sally, Brigham, Elizabeth, Motter, Ruth, Nishioka, Chris, Guido, Terry, Khan, Karen, Kholodenko, Dora, Tanaka, Pearl, Soriano, Ferdie, Quinn, Kevin, Goldbach, Erich, Games, Dora, Ness, Daniel

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APP-selective gamma secretase inhibitor ELND006 effects on brain parenchymal and vascular amyloid beta in the PDAPP mouse model of Alzheimer's disease by Schroeter, Sally, Brigham, Elizabeth, Motter, Ruth, Nishioka, Chris, Guido, Terry, Khan, Karen, Kholodenko, Dora, Tanaka, Pearl, Soriano, Ferdie, Quinn, Kevin, Goldbach, Erich, Games, Dora, Ness, Daniel

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Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration by Brigham, Elizabeth, Quinn, Kevin, Kwong, Grace, Willits, Chris, Goldbach, Erich, Motter, Ruth, Lee, Michael, Hu, Kang, Wallace, William, Kholodenko, Dora, Tang-Tanaka, Pearl, Ni, Huifang, Hemphill, Susanna, Chen, Xiao-hua, Eichenbaum, Tovah, Ruslim, Lany, Nguyen, Lan, Santiago, Pamela, Liao, Anna, Bova, Michael, Probst, Gary, Dappen, Michael, Jagodzinski, Jacek, Basi, Guriqbal, Ness, Daniel

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P3‐320: Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP‐selective gamma‐secretase inhibitor, on amyloid‐β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration by Brigham, Elizabeth, Quinn, Kevin, Kwong, Grace, Willits, Chris, Goldbach, Erich, Motter, Ruth, Lee, Michael, Hu, Kang, Wallace, William, Kholodenko, Dora, Tang-Tanaka, Pearl, Ni, Huifang, Hemphill, Susanna, Chen, Xiao-hua, Eichenbaum, Tovah, Ruslim, Lany, Nguyen, Lan, Santiago, Pamela, Liao, Anna, Bova, Michael, Probst, Gary, Dappen, Michael, Jagodzinski, Jacek, Basi, Guriqbal, Ness, Daniel

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