Search Results - "Tanabe, Osamu"

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction by Shi, Lihong, Cui, Shuaiying, Engel, James D, Tanabe, Osamu

“…Patients with sickle cell disease or β-thalassemia are treated with drugs that aim to reactivate production of fetal hemoglobin, but these drugs are not…”
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Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective by Kuriyama, Shinichi, Metoki, Hirohito, Kikuya, Masahiro, Obara, Taku, Ishikuro, Mami, Yamanaka, Chizuru, Nagai, Masato, Matsubara, Hiroko, Kobayashi, Tomoko, Sugawara, Junichi, Tamiya, Gen, Hozawa, Atsushi, Nakaya, Naoki, Tsuchiya, Naho, Nakamura, Tomohiro, Narita, Akira, Kogure, Mana, Hirata, Takumi, Tsuji, Ichiro, Nagami, Fuji, Fuse, Nobuo, Arai, Tomohiko, Kawaguchi, Yoshio, Higuchi, Shinichi, Sakaida, Masaki, Suzuki, Yoichi, Osumi, Noriko, Nakayama, Keiko, Ito, Kiyoshi, Egawa, Shinichi, Chida, Koichi, Kodama, Eiichi, Kiyomoto, Hideyasu, Ishii, Tadashi, Tsuboi, Akito, Tomita, Hiroaki, Taki, Yasuyuki, Kawame, Hiroshi, Suzuki, Kichiya, Ishii, Naoto, Ogishima, Soichi, Mizuno, Satoshi, Takai-Igarashi, Takako, Minegishi, Naoko, Yasuda, Jun, Igarashi, Kazuhiko, Shimizu, Ritsuko, Nagasaki, Masao, Tanabe, Osamu, Koshiba, Seizo, Hashizume, Hiroaki, Motohashi, Hozumi, Tominaga, Teiji, Ito, Sadayoshi, Tanno, Kozo, Sakata, Kiyomi, Shimizu, Atsushi, Hitomi, Jiro, Sasaki, Makoto, Kinoshita, Kengo, Tanaka, Hiroshi, Kobayashi, Tadao, Kure, Shigeo, Yaegashi, Nobuo, Yamamoto, Masayuki

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Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development by Liu, Jinhua, Li, Yapu, Tong, Jingyuan, Gao, Jie, Guo, Qing, Zhang, Lingling, Wang, Bingrui, Zhao, Hui, Wang, Hongtao, Jiang, Erlie, Kurita, Ryo, Nakamura, Yukio, Tanabe, Osamu, Engel, James Douglas, Bresnick, Emery H., Zhou, Jiaxi, Shi, Lihong

“…In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell…”
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Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation by Keleku-Lukwete, Nadine, Suzuki, Mikiko, Otsuki, Akihito, Tsuchida, Kouhei, Katayama, Saori, Hayashi, Makiko, Naganuma, Eriko, Moriguchi, Takashi, Tanabe, Osamu, Engel, James Douglas, Imaizumi, Masue, Yamamoto, Masayuki

“…Sickle cell disease (SCD) is an inherited disorder caused by a point mutation in the β-globin gene, leading to the production of abnormally shaped red blood…”
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FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells by Liu, Fei, Lee, Jae Y., Wei, Huijun, Tanabe, Osamu, Engel, James D., Morrison, Sean J., Guan, Jun-Lin

“…Little is known about whether autophagic mechanisms are active in hematopoietic stem cells (HSCs) or how they are regulated. FIP200 (200-kDa FAK-family…”
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Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis by Yamauchi, Takafumi, Ochi, Daisuke, Matsukawa, Naomi, Saigusa, Daisuke, Ishikuro, Mami, Obara, Taku, Tsunemoto, Yoshiki, Kumatani, Satsuki, Yamashita, Riu, Tanabe, Osamu, Minegishi, Naoko, Koshiba, Seizo, Metoki, Hirohito, Kuriyama, Shinichi, Yaegashi, Nobuo, Yamamoto, Masayuki, Nagasaki, Masao, Hiyama, Satoshi, Sugawara, Junichi

“…The elucidation of dynamic metabolomic changes during gestation is particularly important for the development of methods to evaluate pregnancy status or…”
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Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery by Saigusa, Daisuke, Okamura, Yasunobu, Motoike, Ikuko N, Katoh, Yasutake, Kurosawa, Yasuhiro, Saijyo, Reina, Koshiba, Seizo, Yasuda, Jun, Motohashi, Hozumi, Sugawara, Junichi, Tanabe, Osamu, Kinoshita, Kengo, Yamamoto, Masayuki

“…Metabolomics is a promising avenue for biomarker discovery. Although the quality of metabolomic analyses, especially global metabolomics (G-Met) using mass…”
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Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells by Matsuda, Yukiko, Uchimura, Arikuni, Satoh, Yasunari, Kato, Naohiro, Toshishige, Masaaki, Kajimura, Junko, Hamasaki, Kanya, Yoshida, Kengo, Hayashi, Tomonori, Noda, Asao, Tanabe, Osamu

“…Spectra and frequencies of spontaneous and X-ray-induced somatic mutations were revealed with mouse long-term hematopoietic stem cells (LT-HSCs) by…”
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Genome-wide association study identifies new loci for albuminuria in the Japanese population by Okuda, Hiroshi, Okamoto, Koji, Abe, Michiaki, Ishizawa, Kota, Makino, Satoshi, Tanabe, Osamu, Sugawara, Junichi, Hozawa, Atsushi, Tanno, Kozo, Sasaki, Makoto, Tamiya, Gen, Yamamoto, Masayuki, Ito, Sadayoshi, Ishii, Tadashi

“…Background Urinary albumin excretion (UAE) is a risk factor for cardiovascular diseases, metabolic syndrome, chronic kidney disease, etc. Only a few…”
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Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells by Cui, Shuaiying, Kolodziej, Katarzyna E., Obara, Naoshi, Amaral-Psarris, Alexandra, Demmers, Jeroen, Shi, Lihong, Engel, James Douglas, Grosveld, Frank, Strouboulis, John, Tanabe, Osamu

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project by Koshiba, Seizo, Motoike, Ikuko, Saigusa, Daisuke, Inoue, Jin, Shirota, Matsuyuki, Katoh, Yasutake, Katsuoka, Fumiki, Danjoh, Inaho, Hozawa, Atsushi, Kuriyama, Shinichi, Minegishi, Naoko, Nagasaki, Masao, Takai‐Igarashi, Takako, Ogishima, Soichi, Fuse, Nobuo, Kure, Shigeo, Tamiya, Gen, Tanabe, Osamu, Yasuda, Jun, Kinoshita, Kengo, Yamamoto, Masayuki

“…Population‐based prospective cohort studies are indispensable for modern medical research as they provide important knowledge on the influences of many kinds…”
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The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation by Lee, Mary P., Tanabe, Osamu, Shi, Lihong, Jearawiriyapaisarn, Natee, Lucas, Daniel, Engel, James Douglas

“…The orphan nuclear receptors TR4 (NR2C2) and TR2 (NR2C1) are the DNA-binding subunits of the macromolecular complex, direct repeat erythroid-definitive, which…”
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Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare by Yasuda, Jun, Kinoshita, Kengo, Katsuoka, Fumiki, Danjoh, Inaho, Sakurai-Yageta, Mika, Motoike, Ikuko N, Kuroki, Yoko, Saito, Sakae, Kojima, Kaname, Shirota, Matsuyuki, Saigusa, Daisuke, Otsuki, Akihito, Kawashima, Junko, Yamaguchi-Kabata, Yumi, Tadaka, Shu, Aoki, Yuichi, Mimori, Takahiro, Kumada, Kazuki, Inoue, Jin, Makino, Satoshi, Kuriki, Miho, Fuse, Nobuo, Koshiba, Seizo, Tanabe, Osamu, Nagasaki, Masao, Tamiya, Gen, Shimizu, Ritsuko, Takai-Igarashi, Takako, Ogishima, Soichi, Hozawa, Atsushi, Kuriyama, Shinichi, Sugawara, Junichi, Tsuboi, Akito, Kiyomoto, Hideyasu, Ishii, Tadashi, Tomita, Hiroaki, Minegishi, Naoko, Suzuki, Yoichi, Suzuki, Kichiya, Kawame, Hiroshi, Tanaka, Hiroshi, Taki, Yasuyuki, Yaegashi, Nobuo, Kure, Shigeo, Nagami, Fuji, Kosaki, Kenjiro, Sutoh, Yoichi, Hachiya, Tsuyoshi, Shimizu, Atsushi, Sasaki, Makoto, Yamamoto, Masayuki

“…Abstract Personalized healthcare (PHC) based on an individual’s genetic make-up is one of the most advanced, yet feasible, forms of medical care. The Tohoku…”
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TRIM28 is essential for erythroblast differentiation in the mouse by Hosoya, Tomonori, Clifford, Mary, Losson, Régine, Tanabe, Osamu, Engel, James Douglas

“…In previous mass spectrometry and coimmune precipitation studies, we identified tripartite motif-containing 28 (TRIM28; also known as transcriptional…”
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Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project by Saito, Sakae, Aoki, Yuichi, Tamahara, Toru, Goto, Maki, Matsui, Hiroyuki, Kawashima, Junko, Danjoh, Inaho, Hozawa, Atsushi, Kuriyama, Shinichi, Suzuki, Yoichi, Fuse, Nobuo, Kure, Shigeo, Yamashita, Riu, Tanabe, Osamu, Minegishi, Naoko, Kinoshita, Kengo, Tsuboi, Akito, Shimizu, Ritsuko, Yamamoto, Masayuki

“…A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the…”
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Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals by Yamaguchi-Kabata, Yumi, Yasuda, Jun, Uruno, Akira, Shimokawa, Kazuro, Koshiba, Seizo, Suzuki, Yoichi, Fuse, Nobuo, Kawame, Hiroshi, Tadaka, Shu, Nagasaki, Masao, Kojima, Kaname, Katsuoka, Fumiki, Kumada, Kazuki, Tanabe, Osamu, Tamiya, Gen, Yaegashi, Nobuo, Kinoshita, Kengo, Yamamoto, Masayuki, Kure, Shigeo

“…Incidence rates of Mendelian diseases vary among ethnic groups, and frequencies of variant types of causative genes also vary among human populations. In this…”
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Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model by Suzuki, Mikiko, Yamazaki, Hiromi, Mukai, Harumi Y., Motohashi, Hozumi, Shi, Lihong, Tanabe, Osamu, Engel, James Douglas, Yamamoto, Masayuki

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain by Sakai, Mai, Takeuchi, Hikaru, Yu, Zhiqian, Kikuchi, Yoshie, Ono, Chiaki, Takahashi, Yuta, Ito, Fumiaki, Matsuoka, Hiroo, Tanabe, Osamu, Yasuda, Jun, Taki, Yasuyuki, Kawashima, Ryuta, Tomita, Hiroaki

“…Aim CX3CR1, a G‐protein‐coupled receptor, is involved in various inflammatory processes. Two non‐synonymous single nucleotide polymorphisms, V249I (rs3732379)…”
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Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals by Yamaguchi-Kabata, Yumi, Yasuda, Jun, Tanabe, Osamu, Suzuki, Yoichi, Kawame, Hiroshi, Fuse, Nobuo, Nagasaki, Masao, Kawai, Yosuke, Kojima, Kaname, Katsuoka, Fumiki, Saito, Sakae, Danjoh, Inaho, Motoike, Ikuko N, Yamashita, Riu, Koshiba, Seizo, Saigusa, Daisuke, Tamiya, Gen, Kure, Shigeo, Yaegashi, Nobuo, Kawaguchi, Yoshio, Nagami, Fuji, Kuriyama, Shinichi, Sugawara, Junichi, Minegishi, Naoko, Hozawa, Atsushi, Ogishima, Soichi, Kiyomoto, Hideyasu, Takai-Igarashi, Takako, Kinoshita, Kengo, Yamamoto, Masayuki

“…Clarifying allele frequencies of disease-related genetic variants in a population is important in genomic medicine; however, such data is not yet available for…”
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Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project by Yasuda, Jun, Katsuoka, Fumiki, Danjoh, Inaho, Kawai, Yosuke, Kojima, Kaname, Nagasaki, Masao, Saito, Sakae, Yamaguchi-Kabata, Yumi, Tadaka, Shu, Motoike, Ikuko N, Kumada, Kazuki, Sakurai-Yageta, Mika, Tanabe, Osamu, Fuse, Nobuo, Tamiya, Gen, Higasa, Koichiro, Matsuda, Fumihiko, Yasuda, Nobufumi, Iwasaki, Motoki, Sasaki, Makoto, Shimizu, Atsushi, Kinoshita, Kengo, Yamamoto, Masayuki

“…Genotype imputation from single-nucleotide polymorphism (SNP) genotype data using a haplotype reference panel consisting of thousands of unrelated individuals…”
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