Search Results - "Tanabe, Kenneth K"

Prognostic and Therapeutic Implications of Microvascular Invasion in Hepatocellular Carcinoma by Erstad, Derek J., Tanabe, Kenneth K.

“…Hepatocellular carcinoma (HCC) is a morbid condition for which surgical and ablative therapy are the only options for cure. Nonetheless, over half of patients…”
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The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: A comprehensive and evidence‐based comparison and review by Fong, Zhi Ven, Tanabe, Kenneth K.

“…Hepatocellular carcinoma (HCC), the most common primary malignancy of the liver, represents 1 of the leading causes of cancer deaths in the world with an…”
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Molecular signatures in hepatocellular carcinoma: A step toward rationally designed cancer therapy by Erstad, Derek J., Fuchs, Bryan C., Tanabe, Kenneth K.

“…Molecular characterization of hepatocellular carcinoma (HCC) has greatly improved our understanding of disease pathogenesis. Mutational analysis, RNA and…”
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Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma by Fuchs, Bryan C., Hoshida, Yujin, Fujii, Tsutomu, Wei, Lan, Yamada, Suguru, Lauwers, Gregory Y., McGinn, Christopher M., DePeralta, Danielle K., Chen, Xintong, Kuroda, Toshihiko, Lanuti, Michael, Schmitt, Anthony D., Gupta, Supriya, Crenshaw, Andrew, Onofrio, Robert, Taylor, Bradley, Winckler, Wendy, Bardeesy, Nabeel, Caravan, Peter, Golub, Todd R., Tanabe, Kenneth K.

“…Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related mortality in the United States. Because of the lack of viable treatment…”
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Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad‐Based Tumor Genotyping by Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias‐Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John

“…Cancers of origin in the gallbladder and bile ducts are rarely curable with current modalities of cancer treatment. Our clinical application of broad‐based…”
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PD-L1 and HLA Class I Antigen Expression and Clinical Course of the Disease in Intrahepatic Cholangiocarcinoma by Sabbatino, Francesco, Villani, Vincenzo, Yearley, Jennifer H, Deshpande, Vikram, Cai, Lei, Konstantinidis, Ioannis T, Moon, Christina, Nota, Sjoerd, Wang, Yangyang, Al-Sukaini, Ahmad, Zhu, Andrew X, Goyal, Lipika, Ting, David T, Bardeesy, Nabeel, Hong, Theodore S, Fernandez-del Castillo, Carlos, Tanabe, Kenneth K, Lillemoe, Keith D, Ferrone, Soldano, Ferrone, Cristina R

“…More effective therapy is needed for intrahepatic cholangiocarcinoma (ICC). The encouraging clinical results obtained with checkpoint molecule-specific…”
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Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer by Yamada, Suguru, MD, PhD, FACS, Fuchs, Bryan C., PhD, Fujii, Tsutomu, MD, PhD, FACS, Shimoyama, Yoshie, MD, PhD, Sugimoto, Hiroyuki, MD, PhD, Nomoto, Shuji, MD, PhD, Takeda, Shin, MD, PhD, Tanabe, Kenneth K., MD, FACS, Kodera, Yasuhiro, MD, PhD, FACS, Nakao, Akimasa, MD, PhD, FACS

“…Background Pancreatic cancer has a dismal prognosis that is attributed to common local invasiveness and metastasis. Epithelial-to-mesenchymal transition (EMT)…”
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Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis by DePeralta, Danielle K., Wei, Lan, Ghoshal, Sarani, Schmidt, Benjamin, Lauwers, Gregory Y., Lanuti, Michael, Chung, Raymond T., Tanabe, Kenneth K., Fuchs, Bryan C.

“…BACKGROUND Hepatocellular carcinoma (HCC)‐associated mortality is increasing at an alarming rate, and there is a readily identifiable cohort of at‐risk…”
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Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges by Hoshida, Yujin, Fuchs, Bryan C, Tanabe, Kenneth K

“…Chronic fibrotic liver diseases such as viral hepatitis eventually develop liver cirrhosis, which causes occurrence of hepatocellular carcinoma (HCC). Given…”
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Molecular MRI quantification of extracellular aldehyde pairs for early detection of liver fibrogenesis and response to treatment by Ning, Yingying, Zhou, Iris Y, Roberts, Jr, Jesse D, Rotile, Nicholas J, Akam, Eman, Barrett, Stephen C, Sojoodi, Mozhdeh, Barr, Matthew N, Punshon, Tracy, Pantazopoulos, Pamela, Drescher, Hannah K, Jackson, Brian P, Tanabe, Kenneth K, Caravan, Peter

“…Liver fibrosis plays a critical role in the evolution of most chronic liver diseases and is characterized by a buildup of extracellular matrix, which can…”
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Epithelial-to-Mesenchymal Transition and Integrin-Linked Kinase Mediate Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Hepatoma Cells by FUCHS, Bryan C, FUJII, Tsutomu, DORFMAN, Jon D, GOODWIN, Jonathan M, ZHU, Andrew X, LANUTI, Michael, TANABE, Kenneth K

“…Hepatocellular carcinoma (HCC) is associated with a poor prognosis due to late diagnoses and a lack of effective treatment options. Epidermal growth factor…”
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Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy by Erstad, Derek J, Sojoodi, Mozhdeh, Taylor, Martin S, Ghoshal, Sarani, Razavi, Allen A, Graham-O'Regan, Katherine A, Bardeesy, Nabeel, Ferrone, Cristina R, Lanuti, Michael, Caravan, Peter, Tanabe, Kenneth K, Fuchs, Bryan C

“…Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable…”
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Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor by Fujii, Tsutomu, Fuchs, Bryan C, Yamada, Suguru, Lauwers, Gregory Y, Kulu, Yakup, Goodwin, Jonathan M, Lanuti, Michael, Tanabe, Kenneth K

“…In the setting of chronic liver injury in humans, epidermal growth factor (EGF) and EGF receptor (EGFR) are up-regulated and have been proposed to have vital…”
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Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma by Sojoodi, Mozhdeh, Wei, Lan, Erstad, Derek J, Yamada, Suguru, Fujii, Tsutomu, Hirschfield, Hadassa, Kim, Rosa S, Lauwers, Gregory Y, Lanuti, Michael, Hoshida, Yujin, Tanabe, Kenneth K, Fuchs, Bryan C

“…Hepatocellular carcinoma (HCC) is a highly morbid condition with lack of effective treatment options. HCC arises from chronically inflamed and damaged liver…”
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Outcome of patients with de novo versus nevus-associated melanoma by Lin, William M., MD, Luo, Su, MD, Muzikansky, Alona, MA, Lobo, Alice Z.C., MD, Tanabe, Kenneth K., MD, Sober, Arthur J., MD, Cosimi, A. Benedict, MD, Tsao, Hensin, MD, PhD, Duncan, Lyn M., MD

“…Background Prior reports indicate a wide range of melanomas in histopathologic contiguity with a nevus, and an associated nevus has unclear prognostic…”
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Morbidity and Mortality after Liver Resection: Results of the Patient Safety in Surgery Study by Virani, Sophia, BS, Michaelson, James S., PhD, Hutter, Matthew M., MD, MPH, FACS, Lancaster, Robert T., MD, Warshaw, Andrew L., MD, FACS, Henderson, William G., MPH, PhD, Khuri, Shukri F., MD, FACS, Tanabe, Kenneth K., MD, FACS

“…Background Liver resection is performed with increasing frequency. Nearly all of the published information on operative mortality and morbidity rates…”
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Epithelial-to-mesenchymal transition predicts prognosis in clinical gastric cancer by Murai, Toshifumi, Yamada, Suguru, Fuchs, Bryan C., Fujii, Tsutomu, Nakayama, Goro, Sugimoto, Hiroyuki, Koike, Masahiko, Fujiwara, Michitaka, Tanabe, Kenneth K., Kodera, Yasuhiro

“…Background Epithelial‐to‐mesenchymal transition (EMT) is considered to play an important role in cancer invasion and metastasis. Methods The mRNA levels of an…”
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Molecular subclasses of hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibition by Schmidt, Benjamin, Wei, Lan, DePeralta, Danielle K., Hoshida, Yujin, Tan, Poh Seng, Sun, Xiaochen, Sventek, Janelle P., Lanuti, Michael, Tanabe, Kenneth K., Fuchs, Bryan C.

“…A recent gene expression classification of hepatocellular carcinoma (HCC) includes a poor survival subclass termed S2 representing about one‐third of all HCC…”
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Commentary on “Can we improve the morbidity and mortality associated with the associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) procedure in the management of colorectal liver metastases?” by Tanabe, Kenneth K., MD

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Molecular MR imaging of liver fibrosis: A feasibility study using rat and mouse models by Polasek, Miloslav, Fuchs, Bryan C, Uppal, Ritika, Schühle, Daniel T, Alford, Jamu K, Loving, Galen S, Yamada, Suguru, Wei, Lan, Lauwers, Gregory Y, Guimaraes, Alexander R, Tanabe, Kenneth K, Caravan, Peter

“…Background & Aims Liver biopsy, the current clinical gold standard for fibrosis assessment, is invasive and has sampling errors, and is not optimal for…”
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