Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin

Acne is a common skin disease that involves the seborrheic area of the face and results from the obstruction of hair follicles followed by inflammation. Careful face washing helps to improve and prevent acne; however, intensive washing has a risk of inducing skin barrier impairment and dry skin, esp...

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Published in:	Journal of dermatology Vol. 42; no. 2; pp. 181 - 188
Main Authors:	Isoda, Kenichi, Seki, Tsuyoshi, Inoue, Yosuke, Umeda, Koji, Nishizaka, Takahiro, Tanabe, Hisateru, Takagi, Yutaka, Ishida, Koichi, Mizutani, Hitoshi
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-02-2015 Wiley Subscription Services, Inc
Subjects:	Acne Acne Vulgaris - complications Acne Vulgaris - drug therapy Acne Vulgaris - pathology Adult barrier function ceramide Ceramides - metabolism Cosmetics industry Detergents - therapeutic use dry skin Epidermis - drug effects Epidermis - metabolism Eucalyptus Female Gels Health & beauty aids Humans Plant Extracts - therapeutic use Sensation Disorders - complications sensitive skin Skin Care - methods Skin Cream - therapeutic use Young Adult ceramide acne sensitive skin dry skin barrier function
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Summary:	Acne is a common skin disease that involves the seborrheic area of the face and results from the obstruction of hair follicles followed by inflammation. Careful face washing helps to improve and prevent acne; however, intensive washing has a risk of inducing skin barrier impairment and dry skin, especially in sensitive skin. We hypothesized that skin care combining mild skin cleansing and intensive moisturizing (“combination skin care”) may be effective in the care of acne in subjects with dry skin and/or sensitive skin. We developed a combination skin care with a weakly acidic foaming facial skin cleanser based on a mild detergent, an aqueous lotion with eucalyptus extract and a moisturizing gel containing pseudo‐ceramide and eucalyptus extract. To optimize an ideal facial skin care system for mild acne on sensitive skin, we performed a 4‐week clinical trial with 29 post‐adolescent Japanese women with mild acne with dry and sensitive skin. The acne significantly decreased after this trial accompanied by the improvement of dry skin, a significantly increased endogenous ceramide level in the stratum corneum and an elongated alkyl chain length of the non‐hydroxy acyl sphingosine type ceramide. No adverse events due to the test samples were observed. Based on diagnosis by a dermatologist, 97% of the subjects found the combination skin care to be “useful” or “slightly useful”. Based on these findings, the combined use of a facial skin cleanser and moisturizers is safe and effective for the care of acne in post‐adolescent Japanese women with sensitive skin.
Bibliography:	Figure S1. A case of magnified images of stratum corneum at week 0 (a) and week 4 (b). A 21-year-old female subject: irregularity of the stratum corneum at week 0 (score 2) had improved at week 4 (score 1). Bar = 1 mm. ArticleID:JDE12720 ark:/67375/WNG-5RZQJ2K0-H istex:3159F37A1546868587C624D3E70DBCE30D6566B0 Kao Corporation KSK Laboratory ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0385-2407 1346-8138
DOI:	10.1111/1346-8138.12720