Search Results - "Tan, Yichen"

Assessment of the Intermediacy of Arylpalladium Carboxylate Complexes in the Direct Arylation of Benzene: Evidence for C−H Bond Cleavage by “Ligandless” Species by Tan, Yichen, Hartwig, John F

“…Palladium-catalyzed direct arylations of benzene have been proposed to occur by the generation of a phosphine-ligated arylpalladium pivalate complex…”
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Mechanistic Studies on Direct Arylation of Pyridine N-Oxide: Evidence for Cooperative Catalysis between Two Distinct Palladium Centers by Tan, Yichen, Barrios-Landeros, Fabiola, Hartwig, John F

“…Direct arylations of pyridine N-oxide (PyO), a convenient method to prepare 2-arylpyridines, catalyzed by Pd­(OAc)2 and PtBu3 have been proposed to occur by…”
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Development of a Platform for Near-Infrared Photoredox Catalysis by Ravetz, Benjamin D, Tay, Nicholas E. S, Joe, Candice L, Sezen-Edmonds, Melda, Schmidt, Michael A, Tan, Yichen, Janey, Jacob M, Eastgate, Martin D, Rovis, Tomislav

“…Over the past decade, chemists have embraced visible-light photoredox catalysis due to its remarkable ability to activate small molecules. Broadly, these…”
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Oxygen nucleophiles as reaction partners in photoinduced, copper-catalyzed cross-couplings: O-arylations of phenols at room temperature by Tan, Yichen, Muñoz-Molina, José María, Fu, Gregory C., Peters, Jonas C.

“…Most copper-catalyzed cross-couplings require an elevated reaction temperature. Recently, a photoinduced variant has been developed that enables C–X…”
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Effects of Volume Ratio, Layout and Leave Size of Indoor Plants on Workers’ Attention Recovery in Factory Staff Break Area by Fang, Zirui, Xu, Hongpeng, Tao, Lulu, Tan, Yichen, Li, Yuqing, Wu, Jianmei

“…A more efficient attention recovery of workers during their break time is essential for achieving higher productivity and wellness. In recent years, the…”
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Palladium-Catalyzed Amination of Aromatic C−H Bonds with Oxime Esters by Tan, Yichen, Hartwig, John F

“…We report a conceptually new approach to the direct amination of aromatic C−H bonds. In this process, an oxime ester function reacts with an aromatic C−H bond…”
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A New Family of Nucleophiles for Photoinduced, Copper-Catalyzed Cross-Couplings via Single-Electron Transfer: Reactions of Thiols with Aryl Halides Under Mild Conditions (O °C) by Uyeda, Christopher, Tan, Yichen, Fu, Gregory C, Peters, Jonas C

“…Building on the known photophysical properties of well-defined copper–carbazolide complexes, we have recently described photoinduced, copper-catalyzed…”
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Sterically Controlled, Palladium-Catalyzed Intermolecular Amination of Arenes by Shrestha, Ruja, Mukherjee, Paramita, Tan, Yichen, Litman, Zachary C, Hartwig, John F

“…We report the Pd-catalyzed amination of arenes to form N-aryl phthalimides with regioselectivity controlled predominantly by steric effects. Mono-, di-, and…”
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Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme by Denard, Carl A., Huang, Hua, Bartlett, Mark J., Lu, Lu, Tan, Yichen, Zhao, Huimin, Hartwig, John F.

“…Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create…”
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A mechanistic investigation of the photoinduced, copper-mediated cross-coupling of an aryl thiol with an aryl halide by Johnson, Miles W, Hannoun, Kareem I, Tan, Yichen, Fu, Gregory C, Peters, Jonas C

“…Photoinduced, copper-catalyzed cross-coupling can offer a complementary approach to thermal (non-photoinduced) methods for generating C-X (X = C, N, O, S,…”
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Development of a Crystallization-Induced Diastereomer Transformation of Oxime Isomers for the Asymmetric Synthesis of (1S,6R)‑3,9-Diazabicyclo[4.2.1]nonane by Lisnyak, Vladislav G., Tan, Yichen, Ramirez, Antonio, Wisniewski, Steven R., Sarjeant, Amy A.

“…Herein we report a practical crystallization-induced diastereomer transformation (CIDT) of oxime isomers for the scalable asymmetric synthesis of the bicyclic…”
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Development of a Chromane-Forming Heck Reaction: Bisphosphine Mono-Oxide Mediated Regioselectivity Perturbed by Solvent-Based Peroxide Formation by Doggett, Adrian, Hay, Michael, McKenna, Shane, Saurer, Eric M., Steinhardt, Sarah, Tan, Yichen, Wilbert, Christopher R., Wisniewski, Steven R.

“…The development of an exocyclic-selective, chromane-forming Heck reaction is reported. Detailed mechanistic studies revealed the crucial role of a bisphosphine…”
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Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195) by Stevens, Jason M., Simmons, Eric M., Tan, Yichen, Borovika, Alina, Fan, Junying, Forest, Robert V., Geng, Peng, Guerrero, Carlos A., Lou, Sha, Skliar, Dimitri, Steinhardt, Sarah E., Strotman, Neil A.

“…The invention of a commercial route to the Bruton's tyrosine kinase inhibitor branebrutinib (BMS-986195) in four total chemical steps is described. The…”
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A Biochemiluminescent Sialidase Assay for Diagnosis of Bacterial Vaginosis by Wu, Shengjun, Lin, Xuexiang, Hui, Kwok Min, Yang, Su, Wu, Xuanlan, Tan, Yichen, Li, Meimei, Qin, Ai-Qing, Wang, Qingxi, Zhao, Qi, Ding, Pengfei, Shi, Kaisheng, Li, X. James

“…Bacterial vaginosis (BV) is a common condition among women of reproductive age. A sensitive, quantitative and rapid assay is needed for the diagnosis of and,…”
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Autoxidation Products of Betulonaldehyde by Ayers, Sloan, Benkovics, Tamas, Marshall, Jonathan, Tan, Yichen, Strotman, Neil A, Kiau, Susanne

“…Three major degradation products resulted from the exposure of betulonaldehyde (1) to air in solution at room temperature. From HRMS and NMR data, the…”
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Coupling-Condensation Strategy for the Convergent Synthesis of an Imidazole-Fused 2‑Aminoquinoline NLRP3 Agonist by Bi, Cong, Chadwick, James, Davies, Merrill L., DelMonte, Albert J., Geng, Peng, Glace, Andrew W., Green, Rebecca A., Gurak, John A., Haley, Matthew W., He, Brian L., Inankur, Bahar, Jamison, Christopher R., Joe, Candice L., Kolotuchin, Sergei, Lin, Dong, Lou, Sha, Nye, Jeffrey, Ortiz, Adrian, Purdum, Geoffrey E., Rosso, Victor W., Shah, Mansi, Simmons, Eric M., Stevens, Jason M., Strotman, Neil A., Tan, Yichen, Zhang, Ling

“…The development of a convergent route to the NLRP3 (nucleotide-binding domain and leucine-rich repeat-containing protein 3) agonist BMS-986299 is reported. The…”
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Synthesis of HIV-Maturation Inhibitor BMS-955176 from Betulin by an Enabling Oxidation Strategy by Ortiz, Adrian, Soumeillant, Maxime, Savage, Scott A, Strotman, Neil A, Haley, Matthew, Benkovics, Tamas, Nye, Jeffrey, Xu, Zhongmin, Tan, Yichen, Ayers, Sloan, Gao, Qi, Kiau, Susanne

“…A concise and scalable second generation synthesis of HIV maturation inhibitor BMS-955176 is described. The synthesis is framed by an oxidation strategy…”
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Rapid Development of a Commercial Process for Linrodostat, an Indoleamine 2,3-Dioxygenase (IDO) Inhibitor by Fraunhoffer, Kenneth J, DelMonte, Albert J, Beutner, Gregory L, Bultman, Michael S, Camacho, Kathryn, Cohen, Benjamin, Dixon, Darryl D, Fan, Yu, Fanfair, Dayne, Freitag, Adam J, Glace, Andrew W, Gonzalez-Bobes, Francisco, Gujjar, Manjunath, Haley, Matthew W, Hickey, Matthew R, Ho, Jeanne, Iyer, Vidya, Maity, Prantik, Patel, Sunil, Rosso, Victor W, Schmidt, Michael A, Stevens, Jason M, Tan, Yichen, Wilbert, Christopher, Young, Ian S, Yu, Miao

“…The process development and the kilogram-scale synthesis of linrodostat (BMS-986205, 1) are described. The synthesis features several highly efficient…”
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Utilizing Native Directing Groups: Mechanistic Understanding of a Direct Arylation Leads to Formation of Tetracyclic Heterocycles via Tandem Intermolecular, Intramolecular C–H Activation by Wisniewski, Steven R, Savage, Scott A, Romero, Evan O, Eastgate, Martin D, Tan, Yichen, Simmons, Eric M, Plata, R. Erik, Sowa, John R, Blackmond, Donna G

“…A mechanistic study on a direct arylation using a native picolylamine directing group is reported. Kinetic studies determined the concentration dependence of…”
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Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4‑(2-Hydroxy­ethyl)­thiomorpholine 1,1-Dioxide by Strotman, Neil A, Tan, Yichen, Powers, Kyle W, Soumeillant, Maxime, Leung, Simon W

“…Continuous processing enabled the highly energetic double conjugate addition of ethanolamine to divinylsulfone to prepare 2 kg of…”
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