Search Results - "Tan, Wuwei"

Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models by Dutta, Avik, Nath, Dipmoy, Yang, Yue, Le, Bao T., Rahman, Mohammad Ferdous-Ur, Faughnan, Patrick, Wang, Zhenjia, Stuver, Matthew, He, Rongquan, Tan, Wuwei, Hutchison, Robert E., Foulks, Jason M., Warner, Steven L., Zang, Chongzhi, Mohi, Golam

“…Myelofibrosis (MF) is the deadliest form of myeloproliferative neoplasm (MPN). The JAK inhibitor Ruxolitinib can reduce constitutional symptoms but it does not…”
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Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements by Chen, Danqi, Chen, Qiao Yi, Wang, Zhenjia, Zhu, Yusha, Kluz, Thomas, Tan, Wuwei, Li, Jinquan, Wu, Feng, Fang, Lei, Zhang, Xiaoru, He, Rongquan, Shen, Steven, Sun, Hong, Zang, Chongzhi, Jin, Chunyuan, Costa, Max

“…Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3′ end. We previously demonstrated that exposure to…”
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Multimodal learning of noncoding variant effects using genome sequence and chromatin structure by Tan, Wuwei, Shen, Yang

“…Abstract Motivation A growing amount of noncoding genetic variants, including single-nucleotide polymorphisms, are found to be associated with complex human…”
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Noncoding variant effect prediction using genome sequence and chromatin structure by Tan, Wuwei, Shen, Yang

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Somatic estrogen receptor [alpha] mutations that induce dimerization promote receptor activity and breast cancer proliferation by Irani, Seema, Tan, Wuwei, Li, Qing, Toy, Weiyi, Jones, Catherine, Gadiya, Mayur, Marra, Antonio, Katzenellenbogen, John A, Carlson, Kathryn E, Katzenellenbogen, Benita S, Karimi, Mostafa, Rajappachetty, Ramya Segu, Del Priore, Isabella S, Reis-Filho, Jorge S, Shen, Yang, Chandarlapaty, Sarat

“…Physiologic activation of estrogen receptor [alpha] (ER[alpha]) is mediated by estradiol (E2) binding in the ligand- binding pocket of the receptor,…”
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Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation by Irani, Seema, Tan, Wuwei, Li, Qing, Toy, Weiyi, Jones, Catherine, Gadiya, Mayur, Marra, Antonio, Katzenellenbogen, John A, Carlson, Kathryn E, Katzenellenbogen, Benita S, Karimi, Mostafa, Segu Rajappachetty, Ramya, Del Priore, Isabella S, Reis-Filho, Jorge S, Shen, Yang, Chandarlapaty, Sarat

“…Physiologic activation of estrogen receptor α (ERα) is mediated by estradiol (E2) binding in the ligand-binding pocket of the receptor, repositioning helix 12…”
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The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles by Schreiber, Jacob, Boix, Carles, Wook Lee, Jin, Li, Hongyang, Guan, Yuanfang, Chang, Chun-Chieh, Chang, Jen-Chien, Hawkins-Hooker, Alex, Schölkopf, Bernhard, Schweikert, Gabriele, Carulla, Mateo Rojas, Canakoglu, Arif, Guzzo, Francesco, Nanni, Luca, Masseroli, Marco, Carman, Mark James, Pinoli, Pietro, Hong, Chenyang, Yip, Kevin Y, Spence, Jeffrey P, Batra, Sanjit Singh, Song, Yun S, Mahony, Shaun, Zhang, Zheng, Tan, Wuwei, Shen, Yang, Sun, Yuanfei, Shi, Minyi, Adrian, Jessika, Sandstrom, Richard, Farrell, Nina, Halow, Jessica, Lee, Kristen, Jiang, Lixia, Yang, Xinqiong, Epstein, Charles, Strattan, J Seth, Bernstein, Bradley, Snyder, Michael, Kellis, Manolis, Stafford, William, Kundaje, Anshul

“…A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational methods to…”
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Abstract PO3-29-03: An Emerging Class of ER mutations Enhances ER Dimerization and Promotes ER Activity by Irani, Seema, Tan, Wuwei, Li, Qing, Toy, Weiyi, Jones, Catherine, Gadiya, Mayur, Marra, Antonio, Katzenellenbogen, John, Carlson, Kathryn, Katzenellenbogen, Benita S., Shen, Yang, Chandarlapaty, Sarat

“…Abstract Physiological activation of estrogen receptor alpha (ERα) requires the binding of estradiol (E2) to the ligand binding domain (LBD) of the receptor…”
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Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project by Stenton, Sarah L, O'Leary, Melanie C, Lemire, Gabrielle, VanNoy, Grace E, DiTroia, Stephanie, Ganesh, Vijay S, Groopman, Emily, O'Heir, Emily, Mangilog, Brian, Osei-Owusu, Ikeoluwa, Pais, Lynn S, Serrano, Jillian, Singer-Berk, Moriel, Weisburd, Ben, Wilson, Michael W, Austin-Tse, Christina, Abdelhakim, Marwa, Althagafi, Azza, Babbi, Giulia, Bellazzi, Riccardo, Bovo, Samuele, Carta, Maria Giulia, Casadio, Rita, Coenen, Pieter-Jan, De Paoli, Federica, Floris, Matteo, Gajapathy, Manavalan, Hoehndorf, Robert, Jacobsen, Julius O B, Joseph, Thomas, Kamandula, Akash, Katsonis, Panagiotis, Kint, Cyrielle, Lichtarge, Olivier, Limongelli, Ivan, Lu, Yulan, Magni, Paolo, Mamidi, Tarun Karthik Kumar, Martelli, Pier Luigi, Mulargia, Marta, Nicora, Giovanna, Nykamp, Keith, Pejaver, Vikas, Peng, Yisu, Pham, Thi Hong Cam, Podda, Maurizio S, Rao, Aditya, Rizzo, Ettore, Saipradeep, Vangala G, Savojardo, Castrense, Schols, Peter, Shen, Yang, Sivadasan, Naveen, Smedley, Damian, Soru, Dorian, Srinivasan, Rajgopal, Sun, Yuanfei, Sunderam, Uma, Tan, Wuwei, Tiwari, Naina, Wang, Xiao, Wang, Yaqiong, Williams, Amanda, Worthey, Elizabeth A, Yin, Rujie, You, Yuning, Zeiberg, Daniel, Zucca, Susanna, Bakolitsa, Constantina, Brenner, Steven E, Fullerton, Stephanie M, Radivojac, Predrag, Rehm, Heidi L, O'Donnell-Luria, Anne

“…A major obstacle faced by families with rare diseases is obtaining a genetic diagnosis. The average "diagnostic odyssey" lasts over five years and causal…”
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