Search Results - "Tan, Var"

Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice by Abad, Catalina, Tan, Yossan-Var

“…A bidirectional cross-talk is established between the nervous and immune systems through common mediators including neuropeptides, neurotransmitters, and…”
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Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases by Couvineau, Alain, Voisin, Thierry, Nicole, Pascal, Gratio, Valérie, Abad, Catalina, Tan, Yossan-Var

“…Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on…”
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Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation by Becquet, Laurine, Abad, Catalina, Leclercq, Mathilde, Miel, Camille, Jean, Laetitia, Riou, Gaëtan, Couvineau, Alain, Boyer, Olivier, Tan, Yossan-Var

“…Orexins (hypocretins, Hcrt) A and B are GPCR-binding hypothalamic neuropeptides known to regulate sleep/wake states and feeding behavior. A few studies have…”
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Class II G protein-coupled receptors for VIP and PACAP: Structure, models of activation and pharmacology by Laburthe, Marc, Couvineau, Alain, Tan, Var

“…VIP and PACAP impact strongly on human pathophysiology. Their receptors are very promising targets for developing new drugs in the treatment of inflammatory…”
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Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation by Kim, Kyun-Do, Srikanth, Sonal, Tan, Yossan-Var, Yee, Ma-Khin, Jew, Marcus, Damoiseaux, Robert, Jung, Michael E, Shimizu, Saki, An, Dong Sung, Ribalet, Bernard, Waschek, James A, Gwack, Yousang

“…Orai1 is the pore subunit of Ca(2+) release-activated Ca(2+) (CRAC) channels that stimulate downstream signaling pathways crucial for T cell activation. CRAC…”
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Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice by Abad, Catalina, Demeules, Mélanie, Guillou, Charlotte, Gondé, Henri, Zoubairi, Rachid, Tan, Yossan-Var, Pinto-Espinoza, Carolina, Schäfer, Waldemar, Mann, Anna Marei, Vouret-Craviari, Valérie, Koch-Nolte, Friedrich, Adriouch, Sahil

“…The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic…”
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Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs by Pinto-Espinoza, Carolina, Guillou, Charlotte, Rissiek, Björn, Wilmes, Maximilian, Javidi, Ehsan, Schwarz, Nicole, Junge, Marten, Haag, Friedrich, Liaukouskaya, Nastassia, Wanner, Nicola, Nicke, Annette, Stortelers, Catelijne, Tan, Yossan-Var, Adriouch, Sahil, Magnus, Tim, Koch-Nolte, Friedrich

“…The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has…”
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Editorial: GPCR in Inflammatory and Cancer Diseases by Couvineau, Alain, Gomariz, Rosa P, Tan, Yossan-Var

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Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis by Tan, Yossan-Var, Abad, Catalina, Lopez, Robert, Dong, Hongmei, Liu, Shen, Lee, Alice, Gomariz, Rosa P, Leceta, Javier, Waschek, James A

“…Pituitary adenylyl cyclase-activating polypeptide (PACAP) is a widely expressed neuropeptide originally discovered in the hypothalamus. It closely resembles…”
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Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist by Ago, Yukio, Condro, Michael C., Tan, Yossan-Var, Ghiani, Cristina A., Colwell, Christopher S., Cushman, Jesse D., Fanselow, Michael S., Hashimoto, Hitoshi, Waschek, James A.

“…Rationale An abundance of genetic and epidemiologic evidence as well as longitudinal neuroimaging data point to developmental origins for schizophrenia and…”
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VIP deficient mice exhibit resistance to lipopolysaccharide induced endotoxemia with an intrinsic defect in proinflammatory cellular responses by Abad, Catalina, Tan, Yossan-Var, Cheung-Lau, Gardenia, Nobuta, Hiroko, Waschek, James A

“…Vasoactive intestinal peptide (VIP) is a pleiotropic neuropeptide with immunomodulatory properties. The administration of this peptide has been shown to have…”
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Pituitary adenylate cyclase activating peptide deficient mice exhibit impaired thymic and extrathymic regulatory T cell proliferation during EAE by Tan, Yossan-Var, Abad, Catalina, Wang, Yuqi, Lopez, Robert, Waschek, James A

“…We have shown that mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP, gene name ADCYAP1) manifest enhanced sensitivity to…”
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Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis by Tan, Yossan-Var, Waschek, James A

“…MS (multiple sclerosis) is a chronic autoimmune and neurodegenerative pathology of the CNS (central nervous system) affecting approx. 2.5 million people…”
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Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction by Ceraudo, Emilie, Hierso, Régine, Tan, Yossan‐Var, Murail, Samuel, Rouyer‐Fessard, Christiane, Nicole, Pascal, Robert, Jean‐Claude, Jamin, Nadège, Neumann, Jean‐Michel, Robberecht, Patrick, Laburthe, Marc, Couvineau, Alain

“…Vasoactive intestinal peptide (VIP) plays a major role in pathophysiology. Our previous studies demonstrated that the VIP sequence 6‐28 interacts with the…”
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Correction: VIP Deficient Mice Exhibit Resistance to Lipopolysaccharide Induced Endotoxemia with an Intrinsic Defect in Proinflammatory Cellular Responses by Abad, Catalina, Tan, Yossan-Var, Cheung-Lau, Gardenia, Nobuta, Hiroko, Waschek, James A.

“…The following sentence was incorrectly cited: "Interestingly, Yadav et al have recently shown that VPAC1 KO mice present milder DSS-induced colitis compared to…”
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Diffuse Pharmacophoric Domains of Vasoactive Intestinal Peptide (VIP) and Further Insights into the Interaction of VIP with the N-terminal Ectodomain of Human VPAC1 Receptor by Photoaffinity Labeling with [Bpa6]-VIP by Tan, Yossan-Var, Couvineau, Alain, Laburthe, Marc

“…The widespread 28-amino acid neuropeptide vasoactive intestinal peptide (VIP) exerts its many biological effects through interaction with serpentine class II G…”
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Photoaffinity Labeling Demonstrates Physical Contact between Vasoactive Intestinal Peptide and the N-terminal Ectodomain of the Human VPAC1 Receptor by Tan, Yossan-Var, Couvineau, Alain, Van Rampelbergh, Jean, Laburthe, Marc

“…Vasoactive intestinal peptide (VIP) is a prominent neuropeptide whose actions are mediated by VPAC receptors belonging to class II G protein-coupled receptors…”
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Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis by Abad, Catalina, Tan, Yossan-Var, Lopez, Robert, Nobuta, Hiroko, Dong, Hongmei, Phan, Phu, Feng, Ji-Ming, Campagnoni, Anthony T., Waschek, James A., Leeman, Susan E.

“…The neuropeptide vasoactive intestinal peptide (VIP) has been shown to inhibit macrophage proinflammatory actions, promote a positive Th2/Th1 balance, and…”
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VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses by Tan, Yossan-Var, Abad, Catalina, Wang, Yuqi, Lopez, Robert, Waschek, James A

“…Highlights • Loss of VPAC2 receptor results in exacerbated EAE. • Th1 and Th17 responses were enhanced and Th2 diminished in VPAC2 KO mice with EAE. • VPAC2 KO…”
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Erratum to: VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage by Abad, Catalina, Jayaram, Bhavaani, Becquet, Laurine, Wang, Yuqi, O'Dorisio, M Sue, Waschek, James A, Tan, Yossan-Var

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