Search Results - "Tan, Tuan Zea"

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia by Zhou, Jianbiao, Yiying Quah, Jessie, Ng, Yvonne, Chooi, Jing-Yuan, Hui-Min Toh, Sabrina, Lin, Baohong, Zea Tan, Tuan, Hosoi, Hiroki, Osato, Motomi, Seet, Qihui, Ooi, Lisa A G, Lindmark, Bertil, McHale, Mark, Chng, Wee-Joo

“…Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute…”
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Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma by Chen, Ye, Xu, Liang, Mayakonda, Anand, Huang, Mo-Li, Kanojia, Deepika, Tan, Tuan Zea, Dakle, Pushkar, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Said, Jonathan W., Chen, Jianxiang, Gery, Sigal, Ding, Ling-Wen, Jiang, Yan-Yi, Pang, Angela, Puhaindran, Mark Edward, Goh, Boon Cher, Koeffler, H. Phillip

“…Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and…”
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BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia by Zhou, Yafeng, Zhou, Jianbiao, Lu, Xiao, Tan, Tuan-Zea, Chng, Wee-Joo

“…Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new…”
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Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation by Kong, Li Ren, Ong, Richard Weijie, Tan, Tuan Zea, Mohamed Salleh, Nur Afiqah Binte, Thangavelu, Matan, Chan, Jane Vin, Koh, Lie Yong Judice, Periyasamy, Giridharan, Lau, Jieying Amelia, Le, Thi Bich Uyen, Wang, Lingzhi, Lee, Miyoung, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Chwee Ming, Chng, Wee Joo, Lane, David P., Venkitaraman, Ashok, Hung, Huynh The, Cheok, Chit Fang, Goh, Boon Cher

“…Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and…”
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The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells by Chung, Vin Yee, Tan, Tuan Zea, Ye, Jieru, Huang, Rui-Lan, Lai, Hung-Cheng, Kappei, Dennis, Wollmann, Heike, Guccione, Ernesto, Huang, Ruby Yun-Ju

“…Cancer cells exhibit phenotypic plasticity during epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) involving intermediate…”
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SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2 by Sundararajan, Vignesh, Tan, Ming, Zea Tan, Tuan, Pang, Qing You, Ye, Jieru, Chung, Vin Yee, Huang, Ruby Yun-Ju

“…Over two decades of research on cancer-associated epithelial-mesenchymal transition (EMT) led us to ascertain the occurrence of transitional intermediate…”
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Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects by Wang, Chelsia Qiuxia, Krishnan, Vaidehi, Tay, Lavina Sierra, Chin, Desmond Wai Loon, Koh, Cai Ping, Chooi, Jing Yuan, Nah, Giselle Sek Suan, Du, Linsen, Jacob, Bindya, Yamashita, Namiko, Lai, Soak Kuan, Tan, Tuan Zea, Mori, Seiichi, Tanuichi, Ichiro, Tergaonkar, Vinay, Ito, Yoshiaki, Osato, Motomi

“…The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis…”
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A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma by Kong, Li Ren, Mohamed Salleh, Nur Afiqah Binte, Ong, Richard Weijie, Tan, Tuan Zea, Syn, Nicholas L., Goh, Robby Miguel, Fhu, Chee Wai, Tan, Daniel S. W., Iyer, N. Gopalakrishna, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Yaw Chyn, Soo, Ross, Ho, Jingshan, Huang, Yiqing, Lim, Joline S. J., Yan, Benedict Junrong, Nga, Min En, Lim, Seng Gee, Koeffler, H. Phillip, Lee, Soo Chin, Kappei, Dennis, Hung, Huynh The, Goh, Boon Cher

“…c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy…”
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Pharmacological Inhibition of TFF3 Enhances Sensitivity of CMS4 Colorectal Carcinoma to 5-Fluorouracil through Inhibition of p44/42 MAPK by Chen, Ru-Mei, Chiou, Yi-Shiou, Chong, Qing-Yun, Poh, Han-Ming, Tan, Tuan-Zea, Zhang, Meng-Yi, Ma, Lan, Zhu, Tao, Pandey, Vijay, Basappa, Kumar, Alan Prem, Lobie, Peter E

“…Increased expression of trefoil factor 3 (TFF3) has been reported in colorectal carcinoma (CRC), being correlated with distant metastasis and poor clinical…”
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The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions by Davidson, Ben, MD PhD, Holth, Arild, BSc, Hellesylt, Ellen, MSc, Tan, Tuan Zea, PhD, Huang, Ruby Yun-Ju, MD PhD, Tropé, Claes, MD PhD, Nesland, Jahn M., MD PhD, Thiery, Jean Paul, PhD

“…Summary We recently identified gene signatures that allow classification of ovarian carcinoma into 5 distinct clinically relevant groups. In the present study,…”
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E74 like ETS transcription factor 3 (ELF3) is a negative regulator of epithelial- mesenchymal transition in bladder carcinoma by Gondkar, Kirti, Patel, Krishna, Krishnappa, Shobha, Patil, Akkamahadevi, Nair, Bipin, Sundaram, Gopinath Meenakshi, Zea, Tan Tuan, Kumar, Prashant

“…Transcription factors are commonly deregulated in various cancers. Here, we evaluated role of ELF3 in pathogenesis of bladder carcinoma (BCa). We confirmed…”
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LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML by Zhou, Jianbiao, Chan, Zit-Liang, Bi, Chonglei, Lu, Xiao, Chong, Phyllis S Y, Chooi, Jing-Yuan, Cheong, Lip-Lee, Liu, Shaw-Cheng, Ching, Ying Qing, Zhou, Yafeng, Osato, Motomi, Tan, Tuan Zea, Ng, Chin Hin, Ng, Siok-Bian, Wang, Shi, Zeng, Qi, Chng, Wee-Joo

“…PRL-3 (PTP4A3), a metastasis-associated phosphatase, is also upregulated in patients with acute myeloid leukemia (AML) and is associated with poor prognosis,…”
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Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C-Mutant Non-Small Cell Lung Cancer by Adachi, Yuta, Ito, Kentaro, Hayashi, Yuko, Kimura, Ryo, Tan, Tuan Zea, Yamaguchi, Rui, Ebi, Hiromichi

“…is among the most commonly mutated oncogene in cancer including non-small cell lung cancer (NSCLC). In early clinical trials, inhibitors targeting G12C-mutant…”
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Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers by Loo, Ser Yue, Syn, Nicholas L., Koh, Angele Pei-Fern, Teng, Janet Cheng-Fei, Deivasigamani, Amudha, Tan, Tuan Zea, Thike, Aye Aye, Vali, Shireen, Kapoor, Shweta, Wang, Xiaoyuan, Wang, Jiong Wei, Tan, Puay Hoon, Yip, George W., Sethi, Gautam, Huang, Ruby Yun-Ju, Hui, Kam Man, Wang, Lingzhi, Goh, Boon Cher, Kumar, Alan Prem

“…Clinical trials repurposing peroxisome proliferator-activated receptor-gamma (PPARγ) agonists as anticancer agents have exhibited lackluster efficacy across a…”
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Dual role of autophagy in hallmarks of cancer by Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem

“…Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and…”
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Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients by Tan, Tuan Zea, Miow, Qing Hao, Miki, Yoshio, Noda, Tetsuo, Mori, Seiichi, Huang, Ruby Yun‐Ju, Thiery, Jean Paul

“…Epithelial‐mesenchymal transition (EMT) is a reversible and dynamic process hypothesized to be co‐opted by carcinoma during invasion and metastasis. Yet, there…”
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A Novel Biologically and Psychologically Inspired Fuzzy Decision Support System: Hierarchical Complementary Learning by Tan, Tuan Zea, Ng, Geok See, Quek, Chai

“…A computational intelligent system that models the human cognitive abilities may promise significant performance in problem learning because a human is…”
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The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200 by Noman, Muhammad Zaeem, Janji, Bassam, Abdou, Abderemane, Hasmim, Meriem, Terry, Stéphane, Tan, Tuan Zea, Mami-Chouaib, Fathia, Thiery, Jean Paul, Chouaib, Salem

“…PD-L1 expression and regulation by mesenchymal tumor cells remain largely undefined. Here, we report that among different EMT-activated MCF7 human breast…”
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Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis by Datta, Arpita, Deng, Shuo, Gopal, Vennila, Yap, Kenneth Chun-Hong, Halim, Clarissa Esmeralda, Lye, Mun Leng, Ong, Mei Shan, Tan, Tuan Zea, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T

“…In cancer cells, a vital cellular process during metastasis is the transformation of epithelial cells towards motile mesenchymal cells called the epithelial to…”
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SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition by Sundararajan, Vignesh, Tan, Ming, Tan, Tuan Zea, Ye, Jieru, Thiery, Jean Paul, Huang, Ruby Yun-Ju

“…Aberrant activation of epithelial to mesenchymal transition (EMT) associated factors were highly correlated with increased mortality in cancer patients. SNAIL…”
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