Search Results - "Tan, Tiong Kit"

Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation by Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung‐Jen, Andersson, Anne‐Marie C., Barrett, Jordan R., Bowden, Thomas A., Draper, Simon J., Townsend, Alain R., Howarth, Mark

“…Matching of symmetry at interfaces is a fundamental obstacle in molecular assembly. Virus‐like particles (VLPs) are important vaccine platforms against…”
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The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine by Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Kit Tan, Tiong, Rijal, Pramila, Chen, Cheng-Pin, Cheng, Shu-Hsing, Lee, Wen-Hsin, Chou, Yu-Chi, Townsend, Alain R, Ma, Che, Huang, Kuan-Ying A

“…Antibody-mediated immunity plays a key role in protection against SARS-CoV-2. We characterized B-cell-derived anti-SARS-CoV-2 RBD antibody repertoires from…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly by Vester, Susan K., Rahikainen, Rolle, Khairil Anuar, Irsyad N. A., Hills, Rory A., Tan, Tiong Kit, Howarth, Mark

“…Proteins can be empowered via SpyTag for anchoring and nanoassembly, through covalent bonding to SpyCatcher partners. Here we generate a switchable version of…”
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Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2 by Huang, Kuan-Ying A., Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Tan, Tiong Kit, Rijal, Pramila, Vester, Susan K., Hills, Rory A., Howarth, Mark, Keeffe, Jennifer R., Cohen, Alexander A., Kakutani, Leesa M., Wu, Yi-Min, Shahed-Al-Mahmud, Md, Chou, Yu-Chi, Bjorkman, Pamela J., Townsend, Alain R., Ma, Che

“…Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection. We isolated a panel of neutralizing anti-receptor-binding domain…”
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An improved method for the rescue of recombinant Newcastle disease virus by Cheow, Pheik-Sheen, Tan, Tiong Kit, Song, Adelene Ai-Lian, Yusoff, Khatijah, Chia, Suet Lin

“…Reverse genetics has been used to generate recombinant Newcastle disease virus with enhanced immunogenic properties for vaccine development. The system, which…”
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Development of a T7 RNA polymerase expressing cell line using lentivirus vectors for the recovery of recombinant Newcastle disease virus by Yeong, Ming Yue, Cheow, Pheik-Sheen, Abdullah, Syahril, Song, Adelene Ai-Lian, Lei-Rossmann, Janet, Tan, Tiong-Kit, Yusoff, Khatijah, Chia, Suet-Lin

“…•Transduction T7 RNA polymerase gene using lentivirus vector.•HEK293-TA-Lv-T7 and SW620-Lv-T7 cell lines was developed.•Rescue of recombinant Newcastle disease…”
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Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors by Kandasamy, Matheswaran, Gileadi, Uzi, Rijal, Pramila, Tan, Tiong Kit, Lee, Lian N, Chen, Jili, Prota, Gennaro, Klenerman, Paul, Townsend, Alain, Cerundolo, Vincenzo

“…Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response,…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

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Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans by Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R

“…[This corrects the article DOI: 10.1371/journal.ppat.1009352.]…”
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Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agents by Gelinas, Amy D., Tan, Tiong Kit, Liu, Sai, Jaramillo, Javier G., Chadwick, James, Harding, Adam C., Zhang, Chi, Ream, Brian E., Chase, Chelsea N., Otis, Matthew R., Lee, Thomas, Schneider, Daniel J., James, William S., Janjic, Nebojsa

“…Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on human health, with infection mortality rates as high as 10%,…”
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A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy by Miao, Xiaoniu, Luo, Yi, Huang, Xi, Lee, Suki M Y, Yuan, Zhijun, Tang, Yongzhou, Chen, Liandi, Wang, Chao, Wu, Fan, Xu, Yifeng, Jiang, Wenchao, Gao, Wei, Song, Xuedong, Yan, Yao, Pang, Tuling, Chen, Cheng, Zou, Yuefeng, Fu, Weihui, Wan, Liping, Gilbert-Jaramillo, Javier, Knight, Michael, Tan, Tiong Kit, Rijal, Pramila, Townsend, Alain, Sun, Joanne, Liu, Xiaolin, James, William, Tsun, Andy, Xu, Yingda

“…In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug to treat COVID-19, the positive results of passive immune…”
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Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses by Tang, Qiannan, Rigby, Rachel E., Young, George R., Hvidt, Astrid Korning, Davis, Tanja, Tan, Tiong Kit, Bridgeman, Anne, Townsend, Alain R., Kassiotis, George, Rehwinkel, Jan

“…Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an unusual left-handed double helix. Here, we studied the biological…”
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain…”
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Development of a recombinant non-replicating Newcastle disease virus by Cheow, Pheik-Sheen, Tan, Tiong Kit, Song, Adelene Ai-Lian, Yusoff, Khatijah, Chia, Suet Lin

“…Development of nr-NDV.Reverse transfection was applied for the recovery of nr-NDV.Propagation of nr-NDV was done by sub-passaging transfected BSR T7/5…”
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Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites by MacLean, Andrew J., Richmond, Niamh, Koneva, Lada, Attar, Moustafa, Medina, Cesar A.P., Thornton, Emily E., Gomes, Ariane Cruz, El-Turabi, Aadil, Bachmann, Martin F., Rijal, Pramila, Tan, Tiong Kit, Townsend, Alain, Sansom, Stephen N., Bannard, Oliver, Arnon, Tal I.

“…Resident memory B (BRM) cells develop and persist in the lungs of influenza-infected mice and humans; however, their contribution to recall responses has not…”
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Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8+ T Cells in the Face of Pre-Existing Humoral Immunity by Zheng, Ming Z M, Fritzlar, Svenja, Wang, Zhongfang, Tan, Tiong Kit, Kedzierska, Katherine, Townsend, Alain, Reading, Patrick C, Wakim, Linda M

“…In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the development of CD8+ T cell…”
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Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans by Rijal, Pramila, Wang, Bei Bei, Tan, Tiong Kit, Schimanski, Lisa, Janesch, Philipp, Dong, Tao, McCauley, John W, Daniels, Rodney S, Townsend, Alain R, Huang, Kuan-Ying A

“…The majority of antibodies induced by influenza neuraminidase (NA), like those against hemagglutinin (HA), are relatively specific to viruses isolated within a…”
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Breadth and function of antibody response to acute SARS-CoV-2 infection in humans by Huang, Kuan-Ying A, Tan, Tiong Kit, Chen, Ting-Hua, Huang, Chung-Guei, Harvey, Ruth, Hussain, Saira, Chen, Cheng-Pin, Harding, Adam, Gilbert-Jaramillo, Javier, Liu, Xu, Knight, Michael, Schimanski, Lisa, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Jan, Jia-Tsrong, Ma, Che, James, William, Daniels, Rodney S, McCauley, John W, Rijal, Pramila, Townsend, Alain R

“…Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different…”
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Pathogen-sugar interactions revealed by universal saturation transfer analysis by Buchanan, Charles J, Gaunt, Ben, Harrison, Peter J, Yang, Yun, Liu, Jiwei, Khan, Aziz, Giltrap, Andrew M, Le Bas, Audrey, Ward, Philip N, Gupta, Kapil, Dumoux, Maud, Tan, Tiong Kit, Schimaski, Lisa, Daga, Sergio, Picchiotti, Nicola, Baldassarri, Margherita, Benetti, Elisa, Fallerini, Chiara, Fava, Francesca, Giliberti, Annarita, Koukos, Panagiotis I, Davy, Matthew J, Lakshminarayanan, Abirami, Xue, Xiaochao, Papadakis, Georgios, Deimel, Lachlan P, Casablancas-Antràs, Virgínia, Claridge, Timothy D W, Bonvin, Alexandre M J J, Sattentau, Quentin J, Furini, Simone, Gori, Marco, Huo, Jiandong, Owens, Raymond J, Schaffitzel, Christiane, Berger, Imre, Renieri, Alessandra, Naismith, James H, Baldwin, Andrew J, Davis, Benjamin G

“…Many pathogens exploit host cell-surface glycans. However, precise analyses of glycan ligands binding with heavily modified pathogen proteins can be confounded…”
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