Search Results - "Tan, Susanna K"

The Human Virome: Implications for Clinical Practice in Transplantation Medicine by Tan, Susanna K, Relman, David A, Pinsky, Benjamin A

“…Advances in DNA sequencing technology have provided an unprecedented opportunity to study the human virome. Transplant recipients and other immunocompromised…”
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HHV‐6 and septic shock: Tenuous proof of causation by Epstein, David J., Tan, Susanna K., Deresinski, Stan

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Follicular Helper T (T FH ) Cell Targeting by TLR8 Signaling For Improving HBsAg-Specific B Cell Response In Chronic Hepatitis B Patients by Ayithan, Natarajan, Tang, Lydia, Tan, Susanna K, Chen, Diana, Wallin, Jeffrey J, Fletcher, Simon P, Kottilil, Shyam, Poonia, Bhawna

“…Identifying signaling pathways that induce B cell response can aid functional cure strategies for chronic hepatitis B infection (CHB). TLR8 activation with…”
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Antiviral kinetics of tenofovir alafenamide and tenofovir disoproxil fumarate over 24 weeks in women of childbearing potential with chronic HBV by Pan, Calvin Q, Chang, Ting-Tsung, Bae, Si Hyun, Brunetto, Maurizia, Seto, Wai-Kay, Coffin, Carla S, Tan, Susanna K, Mo, Shuyuan, Flaherty, John F, Gaggar, Anuj, Nguyen, Mindie H, Çelen, Mustafa Kemal, Thompson, Alexander, Gane, Edward J

“…Use of tenofovir disoproxil fumarate (TDF) improves patient outcomes in preventing mother-to-child transmission (pMTCT) of the hepatitis B virus (HBV) in…”
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Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans by Ayithan, Natarajan, Ghosh, Alip, Dwivedi, Ankit, Wallin, Jeffrey J, Tan, Susanna K, Chen, Diana, Kottilil, Shyam, Poonia, Bhawna

“…TLR8 agonists have the potential for use as immunomodulatory components in therapeutic modalities for viral infections such as chronic HBV (CHB) and HIV. In…”
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Molecular and Culture-Based Bronchoalveolar Lavage Fluid Testing for the Diagnosis of Cytomegalovirus Pneumonitis by Tan, Susanna K., Burgener, Elizabeth B., Waggoner, Jesse J., Gajurel, Kiran, Gonzalez, Sarah, Chen, Sharon F., Pinsky, Benjamin A.

“…Background.  Cytomegalovirus (CMV) is a major cause of morbidity and mortality in immunocompromised patients, with CMV pneumonitis among the most severe…”
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Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019 by Burwick, Richard M, Yawetz, Sigal, Stephenson, Kathryn E, Collier, Ai-Ris Y, Sen, Pritha, Blackburn, Brian G, Kojic, E Milunka, Hirshberg, Adi, Suarez, Jose F, Sobieszczyk, Magdalena E, Marks, Kristen M, Mazur, Shawn, Big, Cecilia, Manuel, Oriol, Morlin, Gregory, Rose, Suzanne J, Naqvi, Mariam, Goldfarb, Ilona T, DeZure, Adam, Telep, Laura, Tan, Susanna K, Zhao, Yang, Hahambis, Tom, Hindman, Jason, Chokkalingam, Anand P, Carter, Christoph, Das, Moupali, Osinusi, Anu O, Brainard, Diana M, Varughese, Tilly A, Kovalenko, Olga, Sims, Matthew D, Desai, Samit, Swamy, Geeta, Sheffield, Jeanne S, Zash, Rebecca, Short, William R

“…Abstract Background Remdesivir is efficacious for severe coronavirus disease 2019 (COVID-19) in adults, but data in pregnant women are limited. We describe…”
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Safety, Pharmacokinetics, and Pharmacodynamics of the Oral TLR8 Agonist Selgantolimod in Chronic Hepatitis B by Gane, Edward J., Kim, Hyung Joon, Visvanathan, Kumar, Kim, Yoon Jun, Nguyen, Anh‐Hoa, Wallin, Jeffrey J., Chen, Diana Y., McDonald, Circe, Arora, Priyanka, Tan, Susanna K., Gaggar, Anuj, Roberts, Stuart K., Lim, Young‐Suk

“…Background and Aims In patients with chronic hepatitis B (CHB) infection, activation of toll‐like receptor 8 may induce antiviral immunity and drive functional…”
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A Randomized, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of VIR-2482 in Healthy Adults for Prevention of Influenza A Illness (PENINSULA) by Tan, Susanna K, Cebrik, Deborah, Plotnik, David, Agostini, Maria L, Boundy, Keith, Hebner, Christy M, Yeh, Wendy W, Pang, Phillip S, Moya, Jaynier, Fogarty, Charles, Darani, Manuchehr, Hayden, Frederick G

“…Influenza A results in significant morbidity and mortality. VIR-2482, an engineered human monoclonal antibody with extended half-life, targets a highly…”
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Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression by Gane, Edward J., Dunbar, P. Rod, Brooks, Anna E., Zhang, Fangqiu, Chen, Diana, Wallin, Jeffrey J., van Buuren, Nicholas, Arora, Priyanka, Fletcher, Simon P., Tan, Susanna K., Yang, Jenny C., Gaggar, Anuj, Kottilil, Shyamasundaran, Tang, Lydia

“…Selgantolimod (GS-9688) is a Toll-like receptor 8 (TLR8) agonist that suppresses HBV in vitro. In a phase II study, we evaluated the safety and efficacy of…”
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Calibration of BK Virus Nucleic Acid Amplification Testing to the 1st WHO International Standard for BK Virus by Tan, Susanna K, Milligan, Stephen, Sahoo, Malaya K, Taylor, Nathaniel, Pinsky, Benjamin A

“…Significant interassay variability in the quantification of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for the management of BKV…”
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Cytomegalovirus load at treatment initiation is predictive of time to resolution of viremia and duration of therapy in hematopoietic cell transplant recipients by Tan, Susanna K, Waggoner, Jesse J, Pinsky, Benjamin A

“…Highlights • Preemptive therapy is the basis of CMV prevention in HCT recipients. • Retrospectively evaluated CMV levels at the initiation of preemptive…”
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Stability of Zika virus in urine: Specimen processing considerations and implications for the detection of RNA targets in urine by Tan, Susanna K., Sahoo, Malaya K., Milligan, Stephen B., Taylor, Nathaniel, Pinsky, Benjamin A.

“…•Studied protocols to maximize detection of ZIKV RNA in urine.•Evaluated temperature, time, ZIKV levels, and use of nucleic acid stabilizers.•At low levels of…”
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Metagenomic Next-Generation Sequencing for Identification and Quantitation of Transplant-Related DNA Viruses by Carpenter, Meredith L, Tan, Susanna K, Watson, Thomas, Bacher, Rowena, Nagesh, Vaishnavi, Watts, Alain, Bentley, Gordon, Weber, Jenna, Huang, ChunHong, Sahoo, Malaya K, Hinterwirth, Armin, Doan, Thuy, Carter, Theodore, Dong, Queeny, Gourguechon, Stéphane, Harness, Eric, Kermes, Sean, Radhakrishnan, Srihari, Wang, Gongbo, Quiroz-Zárate, Alejandro, Ching, Jesus, Pinsky, Benjamin A

“…Infections with DNA viruses are frequent causes of morbidity and mortality in transplant recipients. This study describes the analytical and clinical…”
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Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D HBeAg‐positive chronic hepatitis B by Wagner, Josef, Yuen, Lilly, Littlejohn, Margaret, Sozzi, Vitina, Jackson, Kathy, Martin, Ross, Aeschbacher, Thomas, Suri, Vithika, Tan, Susanna K., Feierbach, Becket, Gaggar, Anuj, Marcellin, Patrick, Buti Ferret, Maria, Janssen, Harry L. A., Gane, Ed, Meagher, Niamh, Price, David J., Wong, Darren, Thompson, Alexander T., Revill, Peter A.

“…Summary Backgrounds and Aims We investigated associations between hepatitis B virus (HBV) genome‐length haplotype number (HN) at baseline in subjects with…”
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Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma? by Lawrence, Lauren E B, Saleem, Atif, Sahoo, Malaya K, Tan, Susanna K, Pinsky, Benjamin A, Natkunam, Yasodha, Kunder, Christian A, Stehr, Henning, Zehnder, James L

“…Abstract Objectives The possibility of a so-called primary lymph node neuroendocrine carcinoma has been described in the literature. Here we evaluate cases…”
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Impact of Pretransplant Donor BK Viruria in Kidney Transplant Recipients by Tan, Susanna K, Huang, Chunhong, Sahoo, Malaya K, Weber, Jenna, Kurzer, Jason, Stedman, Margaret R, Concepcion, Waldo, Gallo, Amy E, Alonso, Diane, Srinivas, Titte, Storch, Gregory A, Subramanian, Aruna K, Tan, Jane C, Pinsky, Benjamin A

“…BK virus (BKV) is a significant cause of nephropathy in kidney transplantation. The goal of this study was to characterize the course and source of BKV in…”
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HBV variants are common in the ‘immune‐tolerant’ phase of chronic hepatitis B by Yuen, Lilly, Revill, Peter A., Rosenberg, Gillian, Wagner, Josef, Littlejohn, Margaret, Bayliss, Julianne, Jackson, Kathy, Tan, Susanna K., Gaggar, Anuj, Kitrinos, Kathryn, Subramanian, Mani, Gane, Ed, Chan, Henry L. Y., Li, Xin, Bowden, Scott, Locarnini, Stephen, Thompson, Alexander

“…Nucleos(t)ide analogues (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However, risk of hepatocellular…”
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Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination by Tan, Susanna K., Granados, Andrea C., Bouquet, Jerome, Hoy-Schulz, Yana Emmy, Green, Lauri, Federman, Scot, Stryke, Doug, Haggerty, Thomas D., Ley, Catherine, Yeh, Ming-Te, Jannat, Kaniz, Maldonado, Yvonne A., Andino, Raul, Parsonnet, Julie, Chiu, Charles Y.

“…The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown…”
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Limited Variation in BK Virus T-Cell Epitopes Revealed by Next-Generation Sequencing by Sahoo, Malaya K, Tan, Susanna K, Chen, Sharon F, Kapusinszky, Beatrix, Concepcion, Katherine R, Kjelson, Lynn, Mallempati, Kalyan, Farina, Heidi M, Fernández-Viña, Marcelo, Tyan, Dolly, Grimm, Paul C, Anderson, Matthew W, Concepcion, Waldo, Pinsky, Benjamin A

“…BK virus (BKV) infection causing end-organ disease remains a formidable challenge to the hematopoietic cell transplant (HCT) and kidney transplant fields. As…”
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