Search Results - "Tan, Sophia K"

Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments by Merz, Gregory E., Chalkley, Matthew J., Tan, Sophia K., Tse, Eric, Lee, Joanne, Prusiner, Stanley B., Paras, Nick A., DeGrado, William F., Southworth, Daniel R.

“…Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of Alzheimer’s disease (AD) and many other neurodegenerative…”
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Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors by Fong, Lam-Kiu, Chalkley, Matthew J., Tan, Sophia K., Grabe, Michael, DeGrado, William F.

“…Multicomponent immune receptors are essential complexes in which distinct ligand-recognition and signaling subunits are held together by interactions between…”
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De novo design of drug-binding proteins with predictable binding energy and specificity by Lu, Lei, Gou, Xuxu, Tan, Sophia K, Mann, Samuel I, Yang, Hyunjun, Zhong, Xiaofang, Gazgalis, Dimitrios, Valdiviezo, Jesús, Jo, Hyunil, Wu, Yibing, Diolaiti, Morgan E, Ashworth, Alan, Polizzi, Nicholas F, DeGrado, William F

“…The de novo design of small molecule-binding proteins has seen exciting recent progress; however, high-affinity binding and tunable specificity typically…”
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Acyl Transfer Catalytic Activity in De Novo Designed Protein with N‑Terminus of α‑Helix As Oxyanion-Binding Site by Naudin, Elise A, McEwen, Alastair G, Tan, Sophia K, Poussin-Courmontagne, Pierre, Schmitt, Jean-Louis, Birck, Catherine, DeGrado, William F, Torbeev, Vladimir

“…The design of catalytic proteins with functional sites capable of specific chemistry is gaining momentum and a number of artificial enzymes have recently been…”
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Computation‐Guided Design of a Stimulus‐Responsive Multienzyme Supramolecular Assembly by Yang, Lu, Dolan, Elliott M., Tan, Sophia K., Lin, Tianyun, Sontag, Eduardo D., Khare, Sagar D.

“…The construction of stimulus‐responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons),…”
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Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts by Tan, Sophia K, Fong, Karen P, Polizzi, Nicholas F, Sternisha, Alex, Slusky, Joanna S. G, Yoon, Kyungchul, DeGrado, William F, Bennett, Joel S

“…Integrin αIIbβ3, a transmembrane heterodimer, mediates platelet aggregation when it switches from an inactive to an active ligand-binding conformation…”
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Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance by Mavor, David, Barlow, Kyle A, Asarnow, Daniel, Birman, Yuliya, Britain, Derek, Chen, Weilin, Green, Evan M, Kenner, Lillian R, Mensa, Bruk, Morinishi, Leanna S, Nelson, Charlotte A, Poss, Erin M, Suresh, Pooja, Tian, Ruilin, Arhar, Taylor, Ary, Beatrice E, Bauer, David P, Bergman, Ian D, Brunetti, Rachel M, Chio, Cynthia M, Dai, Shizhong A, Dickinson, Miles S, Elledge, Susanna K, Helsell, Cole V M, Hendel, Nathan L, Kang, Emily, Kern, Nadja, Khoroshkin, Matvei S, Kirkemo, Lisa L, Lewis, Greyson R, Lou, Kevin, Marin, Wesley M, Maxwell, Alison M, McTigue, Peter F, Myers-Turnbull, Douglas, Nagy, Tamas L, Natale, Andrew M, Oltion, Keely, Pourmal, Sergei, Reder, Gabriel K, Rettko, Nicholas J, Rohweder, Peter J, Schwarz, Daniel M C, Tan, Sophia K, Thomas, Paul V, Tibble, Ryan W, Town, Jason P, Tsai, Mary K, Ugur, Fatima S, Wassarman, Douglas R, Wolff, Alexander M, Wu, Taia S, Bogdanoff, Derek, Li, Jennifer, Thorn, Kurt S, O'Conchúir, Shane, Swaney, Danielle L, Chow, Eric D, Madhani, Hiten D, Redding, Sy, Bolon, Daniel N, Kortemme, Tanja, DeRisi, Joseph L, Kampmann, Martin, Fraser, James S

“…Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection…”
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