Search Results - "Tan, Shiming"
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1
The cancer metabolic reprogramming and immune response
Published in Molecular cancer (05-02-2021)“…The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence…”
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Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
Published in Experimental & molecular medicine (01-07-2023)“…Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In cancer cells, metabolic pathway activity varies during tumorigenesis and…”
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3
Cancer stem cells in progression of colorectal cancer
Published in Oncotarget (07-09-2018)“…Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer…”
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4
Exosomal miRNAs in tumor microenvironment
Published in Journal of experimental & clinical cancer research (16-04-2020)“…Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune…”
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The roles of glucose metabolic reprogramming in chemo- and radio-resistance
Published in Journal of experimental & clinical cancer research (23-05-2019)“…Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased…”
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Rac1, A Potential Target for Tumor Therapy
Published in Frontiers in oncology (17-05-2021)“…RAS-related C3 botulinum toxin substrate 1 (Rac.1) is one of the important members of Rho GTPases. It is well known that Rac1 is a cytoskeleton regulation…”
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Rac1 promotes the reprogramming of glucose metabolism and the growth of colon cancer cells through upregulating SOX9
Published in Cancer science (01-03-2023)“…Metabolic reprogramming is the survival rule of tumor cells, and tumor cells can meet their high metabolic requirements by changing the energy metabolism mode…”
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Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment
Published in Journal of experimental & clinical cancer research (10-03-2023)“…Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the tumor microenvironment (TME), tumor cells adopt multiple metabolic…”
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LPLUNC1 reduces glycolysis in nasopharyngeal carcinoma cells through the PHB1‐p53/c‐Myc axis
Published in Cancer science (01-03-2023)“…Cancer cells prefer glycolysis to support their proliferation. Our previous studies have shown that the long palate, lung, and nasal epithelial cell clone 1…”
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Circular RNA hsa_circ_0000467 promotes colorectal cancer progression by promoting eIF4A3-mediated c-Myc translation
Published in Molecular cancer (31-07-2024)“…Colorectal cancer (CRC) is the second most common malignant tumor worldwide, and its incidence rate increases annually. Early diagnosis and treatment are…”
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The function of prohibitins in mitochondria and the clinical potentials
Published in Cancer cell international (08-11-2022)“…Abstract Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell…”
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The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming
Published in Cancer cell international (18-01-2024)“…One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy…”
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13
The functions and mechanisms of prefoldin complex and prefoldin-subunits
Published in Cell & bioscience (20-07-2020)“…Abstract The correct folding is a key process for a protein to acquire its functional structure and conformation. Prefoldin is a well-known chaperone protein…”
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Induction of Pro-Inflammatory Response via Activated Macrophage-Mediated NF-κB and STAT3 Pathways in Gastric Cancer Cells
Published in Cellular physiology and biochemistry (01-01-2018)“…Background/Aims: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, the role and relationship of…”
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The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
Published in Frontiers in oncology (23-01-2023)“…Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a…”
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RAC1 Involves in the Radioresistance by Mediating Epithelial-Mesenchymal Transition in Lung Cancer
Published in Frontiers in oncology (28-04-2020)“…Radiation therapy is a common and acceptable approach for lung cancer. Although the benefit of ionizing radiation (IR) is well-established, cancer cells can…”
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Cellular metabolism: A key player in cancer ferroptosis
Published in Cancer communications (London, England) (01-02-2024)“…Cellular metabolism is the fundamental process by which cells maintain growth and self‐renewal. It produces energy, furnishes raw materials, and intermediates…”
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Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2
Published in Molecular therapy. Oncolytics (17-03-2022)“…The aim of this study was to investigate whether and how exosomal miR-205-5p regulated angiogenesis and nasopharyngeal carcinoma (NPC) metastasis. We found…”
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Endoplasmic reticulum stress—a key guardian in cancer
Published in Cell death discovery (30-07-2024)“…Endoplasmic reticulum stress (ERS) is a cellular stress response characterized by excessive contraction of the endoplasmic reticulum (ER). It is a pathological…”
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Organoids: opportunities and challenges of cancer therapy
Published in Frontiers in cell and developmental biology (27-07-2023)“…Organoids are a class of multicellular structures with the capability of self-organizing and the characteristic of original tissues, they are generated from…”
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