Search Results - "Tan, Shanzhong"

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells by Zhang, Zili, Guo, Mei, Li, Yujia, Shen, Min, Kong, Desong, Shao, Jiangjuan, Ding, Hai, Tan, Shanzhong, Chen, Anping, Zhang, Feng, Zheng, Shizhong

“…Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding…”
Get full text

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells by Zhang, Zili, Guo, Mei, Shen, Min, Kong, Desong, Zhang, Feng, Shao, Jiangjuan, Tan, Shanzhong, Wang, Shijun, Chen, Anping, Cao, Peng, Zheng, Shizhong

“…Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms are not fully understood. In the current study, we reported…”
Get full text

Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway by Li, Yujia, Jin, Chun, Shen, Min, Wang, Zhenyi, Tan, Shanzhong, Chen, Anping, Wang, Shijun, Shao, Jiangjuan, Zhang, Feng, Zhang, Zili, Zheng, Shizhong

“…Currently, the existing treatments have not cured the liver fibrosis thoroughly. Ferroptosis is a newly discovered way of cell death, which is closely related…”
Get full text

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells by Jia, Yan, Wang, Feixia, Guo, Qin, Li, Mengmeng, Wang, Ling, Zhang, Zili, Jiang, Shuoyi, Jin, Huanhuan, Chen, Anping, Tan, Shanzhong, Zhang, Feng, Shao, Jiangjuan, Zheng, Shizhong

“…It is generally recognized that hepatic fibrogenesis is an end result of increased extracellular matrix (ECM) production from the activation and proliferation…”
Get full text

Identification of the Immune Cell Infiltration Landscape in Hepatocellular Carcinoma to Predict Prognosis and Guide Immunotherapy by Yang, Shiyan, Cheng, Yajun, Wang, Xiaolong, Wei, Ping, Wang, Hui, Tan, Shanzhong

“…Globally, hepatocellular carcinoma (HCC) is the sixth most frequent malignancy with a high incidence and a poor prognosis. Immune cell infiltration (ICI)…”
Get full text

Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells by Wang, Feixia, Jia, Yan, Li, Mengmeng, Wang, Ling, Shao, Jiangjuan, Guo, Qinglong, Tan, Shanzhong, Ding, Hai, Chen, Anping, Zhang, Feng, Zheng, Shizhong

“…Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and…”
Get full text

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1 by Shao, Jiangjuan, Li, Mengmeng, Guo, Zijian, Jin, Chun, Zhang, Feng, Ou, Chunyan, Xie, Yaochen, Tan, Shanzhong, Wang, Zhenyi, Zheng, Shizhong, Wang, Xiaoyong

“…In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In…”
Get full text

Chinese herbal decoction, Yi-Qi-Jian-Pi formula exerts anti-hepatic fibrosis effects in mouse models of CCl4-induced liver fibrosis by Yang, Shiyan, Cheng, Yajun, Wang, Xiaolong, Yue, Suyang, Wang, Xi, Tang, Li, Li, Hailun, Zhang, Jie, Xiong, Qingping, Tan, Shanzhong

“…Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients with liver failure. However, scientific evidence supporting the treatment of…”
Get full text

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro by Wang, Feixia, Tang, Li, Liang, Baoyu, Jin, Chun, Gao, Liyuan, Li, Yujia, Li, Zhanghao, Shao, Jiangjuan, Zhang, Zili, Tan, Shanzhong, Zhang, Feng, Zheng, Shizhong

“…Acute-on-chronic liver failure (ACLF) is described as a characteristic of acute jaundice and coagulation dysfunction. Effective treatments for ACLF are…”
Get full text

Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease by Kai, Jun, Yang, Xiang, Wang, Zhimin, Wang, Feixia, Jia, Yan, Wang, Shijun, Tan, Shanzhong, Chen, Anping, Shao, Jiangjuan, Zhang, Feng, Zhang, Zili, Zheng, Shizhong

“…It is well acknowledged that alcoholic liver disease (ALD) is widely prevalent all over the world, characterized by aberrant lipid deposition and excessive…”
Get full text

Yi-Qi-Jian-Pi formula inhibits hepatocyte pyroptosis through the IDH2-driven tricarboxylic acid cycle to reduce liver injury in acute-on-chronic liver failure by Zhao, Rong, Zhao, Qiang, Wang, Xi, Chen, Xiaomei, Liang, Chongfeng, Xiao, Qian, Yang, Shiyan, Tan, Shanzhong

“…Yi-Qi-Jian-Pi formula (YQJPF) is a commonly used traditional Chinese medicine (TCM) compound used to treat acute-on-chronic liver failure (ACLF) in China, but…”
Get full text

Yi-Qi-Jian-Pi formula ameliorates immune function in acute-on-chronic liver failure by upregulating autophagy and mitochondrial biogenesis in CD8+ T lymphocytes by Tang, Li, Wang, Xi, Zhao, Rong, Chen, Xiaomei, Wang, Feixia, Xia, Siwei, Xiao, Qian, Zhao, Qiang, Yang, Shiyan, Tan, Shanzhong

“…A key event in the pathogenesis of acute-on-chronic liver failure (ACLF) is the imbalance in the systemic immune response; immunosuppression in patients with…”
Get full text

Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro by Tang, Li, Wang, Feixia, Xiao, Lingyan, Shen, Min, Xia, Siwei, Zhang, Zili, Zhang, Feng, Zheng, Shizhong, Tan, Shanzhong

“…Acute-on-chronic liver failure (ACLF) is a key complication of chronic hepatitis, with a relatively high mortality rate and limited treatment options, which…”
Get full text

Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1 by Zhang, Feng, Wang, Feixia, He, Jianlin, Lian, Naqi, Wang, Zhenyi, Shao, Jiangjuan, Ding, Hai, Tan, Shanzhong, Chen, Anping, Zhang, Zili, Wang, Shijun, Zheng, Shizhong

“…Background and Purpose Portal hypertension is a lethal complication of cirrhosis. Its mechanism and therapeutic targets remain largely unknown. Hepatic…”
Get full text

HIF-1α-upregulated lncRNA-H19 regulates lipid droplet metabolism through the AMPKα pathway in hepatic stellate cells by Wang, Zhimin, Yang, Xiang, Kai, Jun, Wang, Feixia, Wang, Zhenyi, Shao, Jiangjuan, Tan, Shanzhong, Chen, Anping, Zhang, Feng, Wang, Shijun, Zhang, Zili, Zheng, Shizhong

“…Activation of hepatic stellate cells (HSCs) is a central event in the pathogenesis of liver fibrosis and is characterized by the disappearance of lipid…”
Get full text

Peripheral T lymphocytes predict the severity and prognosis in patients with HBV-related acute-on-chronic liver failure by Wang, Feixia, Sun, Weiwei, Xiao, Qian, Liang, Chongfeng, Jiang, Shulian, Lian, Yanan, Shao, Jiangjuan, Tan, Shanzhong, Zheng, Shizhong

“…Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a life-threatening syndrome with high mortality. Biomarkers are urgently needed to…”
Get full text

ROS-dependent inhibition of the PI3K/Akt/mTOR signaling is required for Oroxylin A to exert anti-inflammatory activity in liver fibrosis by Shen, Min, Guo, Mei, Wang, Zhenyi, Li, Yujia, Kong, Desong, Shao, Jiangjuan, Tan, Shanzhong, Chen, Anping, Zhang, Feng, Zhang, Zili, Zheng, Shizhong

“…[Display omitted] •Oroxylin A decreased the release of inflammatory factors in HSCs.•Oroxylin A exerted anti-inflammatory effect through PI3K/Akt/mTOR…”
Get full text

Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells by Gao, Liyuan, Yang, Xiang, Li, Yang, Wang, Zhenyi, Wang, Shijun, Tan, Shanzhong, Chen, Anping, Cao, Peng, Shao, Jiangjuan, Zhang, Zili, Zhang, Feng, Zheng, Shizhong

“…Liver fibrosis is a difficult problem in the medical field. We previously reported that curcumol, a bioactive substance, may inhibit the pathological…”
Get full text

Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells by Jia, Yan, Gao, Liyuan, Yang, Xiang, Zhang, Feng, Chen, Anping, Wang, Shijun, Shao, Jiangjuan, Tan, Shanzhong, Zheng, Shizhong

“…[Display omitted] Curcumol, a guaiane-type sesquiterpenoid hemiketal extracted from the herb Rhizoma Curcumae, exhibits multiple-pharmacological activities. We…”
Get full text

Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells by Zhang, Zili, Guo, Mei, Shen, Min, Li, Yujia, Tan, Shanzhong, Shao, Jiangjuan, Zhang, Feng, Chen, Anping, Wang, Shijun, Zheng, Shizhong

“…Proliferation and differentiation of hepatic stellate cells (HSCs) are the most noticeable events in hepatic fibrosis, in which the loss of lipid droplets…”
Get full text