Search Results - "Tan, Rui Zhen"

Systematic Identification of Signal-Activated Stochastic Gene Regulation by Neuert, Gregor, Munsky, Brian, Tan, Rui Zhen, Teytelman, Leonid, Khammash, Mustafa, van Oudenaarden, Alexander

“…Although much has been done to elucidate the biochemistry of signal transduction and gene regulatory pathways, it remains difficult to understand or predict…”
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Impact of delta check time intervals on error detection capability by Tan, Rui Zhen, Markus, Corey, Loh, Tze Ping

“…Background The delta check time interval limit is the maximum time window within which two sequential results of a patient will be evaluated by the delta check…”
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A computational model for how cells choose temporal or spatial sensing during chemotaxis by Tan, Rui Zhen, Chiam, Keng-Hwee

“…Cell size is thought to play an important role in choosing between temporal and spatial sensing in chemotaxis. Large cells are thought to use spatial sensing…”
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The Use of Bone-Turnover Markers in Asia-Pacific Populations by Vasikaran, Samuel, Thambiah, Subashini C., Tan, Rui Zhen, Loh, Tze Ping

“…Bone-turnover marker (BTM) measurements in the blood or urine reflect the bone-remodeling rate and may be useful for studying and clinically managing metabolic…”
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An Objective Approach to Deriving the Clinical Performance of Autoverification Limits by Loh, Tze Ping, Tan, Rui Zhen, Lim, Chun Yee, Markus, Corey

“…This study describes an objective approach to deriving the clinical performance of autoverification rules to inform laboratory practice when implementing them…”
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The role of apical contractility in determining cell morphology in multilayered epithelial sheets and tubes by Tan, Rui Zhen, Lai, Tanny, Chiam, K-H

“…A multilayered epithelium is made up of individual cells that are stratified in an orderly fashion, layer by layer. In such tissues, individual cells can adopt…”
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Transcript counting in single cells reveals dynamics of rDNA transcription by Tan, Rui Zhen, van Oudenaarden, Alexander

“…Most eukaryotes contain many tandem repeats of ribosomal RNA genes of which only a subset is transcribed at any given time. Current biochemical methods allow…”
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Computational modeling reveals that a combination of chemotaxis and differential adhesion leads to robust cell sorting during tissue patterning by Tan, Rui Zhen, Chiam, Keng-Hwee

“…Robust tissue patterning is crucial to many processes during development. The "French Flag" model of patterning, whereby naïve cells in a gradient of…”
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Functional Reference Limits: Describing Physiological Relationships and Determination of Physiological Limits for Enhanced Interpretation of Laboratory Results by Chuah, Tyng Yu, Lim, Chun Yee, Tan, Rui Zhen, Pratumvinit, Busadee, Loh, Tze Ping, Vasikaran, Samuel, Markus, Corey

“…Functional reference limits describe key changes in the physiological relationship between a pair of physiologically related components. Statistically, this…”
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Deconvolving the roles of Wnt ligands and receptors in sensing and amplification by Tan, Rui Zhen, Ji, Ni, Mentink, Remco A, Korswagen, Hendrik C, van Oudenaarden, Alexander

“…Establishment of cell polarity is crucial for many biological processes including cell migration and asymmetric cell division. The establishment of cell…”
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A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow of WHIM mouse model by Yip, Ai Kia, Balachander, Akhila, Tan, Leonard D.L., Liong, Ka Hang, Tan, Rui Zhen, Balabanian, Karl, Bachelerie, Francoise, Ng, Lai Guan, Chiam, Keng-Hwee

“…Neutrophils are essential immune cells that defend the host against pathogenic microbial agents. Neutrophils are produced in the bone marrow and are retained…”
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The effects of cellular interactions on the sizes, composition, and dynamics of migrating cancer cell clusters by Tan, Rui Zhen

“…Collective migration plays an important role in metastasis, promoting survival of migrating clusters and increasing malignancy. Hybrid cells in intermediate…”
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Tumour Growth Mechanisms Determine Effectiveness of Adaptive Therapy in Glandular Tumours by Tan, Rui Zhen

“…In cancer treatment, adaptive therapy holds promise for delaying the onset of recurrence through regulating the competition between drug-sensitive and…”
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Comparison of 8 methods for univariate statistical exclusion of pathological subpopulations for indirect reference intervals and biological variation studies by Tan, Rui Zhen, Markus, Corey, Vasikaran, Samuel, Loh, Tze Ping

“…•8 methods for identification/exclusion of pathological subpopulations were compared.•The methods were assessed against 256 simulated mixed population…”
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Bone turnover marker monitoring in osteoporosis treatment response by Tan, Rui Zhen, Loh, Tze Ping, Vasikaran, Samuel

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Comparison of two (data mining) indirect approaches for between-subject biological variation determination by Tan, Rui Zhen, Markus, Corey, Vasikaran, Samuel, Loh, Tze Ping

“…•Two indirect approaches for deriving between-subject biological variation were compared.•The approaches were expected Mean Squares (EMS) and Harris and…”
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Relationship between biological variation and delta check rules performance by Tan, Rui Zhen, Markus, Corey, Loh, Tze Ping

“…•Performance of delta check rules may be dependent on the biological variation.•Mathematical models were developed to explore these relationships.•Sensitivity…”
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An approach to optimize delta checks in test panels - The effect of the number of rules included by Tan, Rui Zhen, Markus, Corey, Loh, Tze Ping

“…The interpretation of delta check rules in a panel of tests should be different to that at the single analyte level, as the number of hypothesis tests…”
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Evidence-based approach to setting delta check rules by Markus, Corey, Tan, Rui Zhen, Loh, Tze Ping

“…Delta checks are a post-analytical verification tool that compare the difference in sequential laboratory results belonging to the same patient against a…”
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Internal quality control: Moving average algorithms outperform Westgard rules by Poh, Daren Kiat How, Lim, Chun Yee, Tan, Rui Zhen, Markus, Corey, Loh, Tze Ping

“…•Westgard quality control rules have poor error detection capability unless combined.•Moving average algorithms applied on quality control data outperform…”
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