The short-term and long-term effects of Dendrobium officinale leaves polysaccharides on the gut microbiota differ

[Display omitted] •SHIME was applied to investigate the difference between short-term and long-term intake of DOLP.•Long-term exposure may be more beneficial for promoting the growth of bacteria associated with attenuating diarrhea.•Short-term effects may be more favorable for promoting the growth o...

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Bibliographic Details
Published in:	Journal of functional foods Vol. 110; p. 105807
Main Authors:	Yang, Ying, Tao, Wenyang, Zhou, Wanyi, Li, Jingrui, Xing, Jianrong, Luo, Mengfan, Tan, Quanqing
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-11-2023 Elsevier
Subjects:	Continuous fermentation Dendrobium officinale leaves polysaccharides In vitro fermentation Microbiota Microbiota In vitro fermentation Continuous fermentation Dendrobium officinale leaves polysaccharides
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Summary:	[Display omitted] •SHIME was applied to investigate the difference between short-term and long-term intake of DOLP.•Long-term exposure may be more beneficial for promoting the growth of bacteria associated with attenuating diarrhea.•Short-term effects may be more favorable for promoting the growth of bacteria related with weight loss and lipid reduction.•Alistipes and Oscillibacter were the key genera in regulating the gut microbiota structure by DOLP. The effect of active substances on the gut microbiota is not immediate, especially for some chronic diseases. This study used an in vitro continuous fermentation system to monitor the changes of gut microbiota in three different colon regions under long-term/short-term DOLP treatment. The results showed that the microbial diversity reached peak on 5th day and remained stable thereafter. Beta diversity analysis showed that the gut microbiota structures of the three regions gradually approached during fermentation. The contents of propionic acid, butyric acid, and valeric acid first increased and then decreased, while isobutyric acid and isovaleric acid first decreased and then increased. Alistipes and Oscillibacter were the key genera in regulating the gut microbiota structure. In summary, Long-term consumption of DOLP has varying effects on the gut microbiota over time, and for the purpose of adjusting the gut microbiota, the most effective duration appears to be continuous consumption for 5 days.
ISSN:	1756-4646 2214-9414
DOI:	10.1016/j.jff.2023.105807