Search Results - "Tan, Qiu Xuan"
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The immunomodulatory role of paracrine signalling factor VSIG4 in peritoneal metastases
Published in Scientific reports (30-07-2024)“…Peritoneal metastasis (PM), the regional progression of intra-abdominal malignancies, is a common sequelae of colorectal cancer (CRC). Immunotherapy is slated…”
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A machine learning approach to identify predictive molecular markers for cisplatin chemosensitivity following surgical resection in ovarian cancer
Published in Scientific reports (19-08-2021)“…Ovarian cancer is associated with poor prognosis. Platinum resistance contributes significantly to the high rate of tumour recurrence. We aimed to identify a…”
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Effect of HIPEC on Peritoneal Recurrence in Peritoneal Metastasis Treated With Cytoreductive Surgery: A Systematic Review
Published in Frontiers in oncology (03-12-2021)“…Peritoneal metastasis (PM) is a late-stage manifestation of intra-abdominal malignancies. The current standard of care indicates that cure can only be achieved…”
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Transcriptomic convergence despite genomic divergence drive field cancerization in synchronous squamous tumors
Published in Frontiers in oncology (13-06-2024)“…Field cancerization is suggested to arise from imbalanced differentiation in individual basal progenitor cells leading to clonal expansion of mutant cells that…”
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A systematic review on quality of life (QoL) of patients with peritoneal metastasis (PM) who underwent pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Published in Pleura and peritoneum (03-06-2022)“…Abstract Background Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has recently emerged as a palliative alternative for patients with unresectable…”
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Generating patient-derived ascites-dependent xenograft mouse models of peritoneal carcinomatosis
Published in STAR protocols (16-09-2022)“…Clinically relevant animal models are crucial for effective development of therapeutics for peritoneal carcinomatosis (PC). This protocol describes the…”
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Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal sarcomatosis—A systematic review and meta-analysis
Published in European journal of surgical oncology (01-03-2022)“…Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) play an important role in the treatment of various peritoneal surface…”
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Postoperative Inflammatory Marker Surveillance in Colorectal Peritoneal Carcinomatosis
Published in Annals of surgical oncology (01-10-2021)“…Background The prognostic significance of inflammatory markers in solid cancers is well-established, albeit with considerable heterogeneity. This study sought…”
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Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases
Published in Gastroenterology (New York, N.Y. 1943) (01-12-2024)“…Peritoneal metastasis (PM) in gastric cancer (GC) is associated with poor prognosis and significant morbidity. We sought to understand the genomic,…”
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ASO Author Reflections: Postoperative Inflammatory Markers as a Surveillance Tool in Colorectal Peritoneal Carcinomatosis
Published in Annals of surgical oncology (01-10-2021)Get full text
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Abstract 2759: Transcriptional intra-tumoral heterogeneity of putative therapeutic targets in colorectal cancer peritoneal metastases
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Background: The poor prognosis of peritoneal metastasis (PM) in colorectal cancer (CRC) is typically attributed to, and characterized by, resistance…”
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A set of molecular markers predicts chemosensitivity to Mitomycin-C following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis
Published in Scientific reports (22-07-2019)“…Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significant perioperative morbidity and mortality. We aim…”
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An Optimised Protocol Harnessing Laser Capture Microdissection for Transcriptomic Analysis on Matched Primary and Metastatic Colorectal Tumours
Published in Scientific reports (20-01-2020)“…Generation of large amounts of genomic data is now feasible and cost-effective with improvements in next generation sequencing (NGS) technology. Ribonucleic…”
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The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis
Published in Cancers (18-08-2021)“…Peritoneal carcinomatosis (PC) is often associated with malnutrition and an inability to tolerate enteral feeding. Although total parenteral nutrition (TPN)…”
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Pairing a prognostic target with potential therapeutic strategy for head and neck cancer
Published in Oral oncology (01-12-2020)“…•Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide.•Previous study showed that a 3 gene IHC panel can prognosticate patients…”
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Abstract 989: Ascites in colorectal peritoneal carcinomatosis supersedes mutational status and other clinical variables as negative prognostic factor for CRS-HIPEC via EMT pathway
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Peritoneal metastasis in colorectal cancer, also known as colorectal peritoneal carcinomatosis (CPC), signifies poor prognosis for patients and is…”
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Abstract 5132: The immunomodulatory role of paracrine signaling factor VSIG4 in peritoneal cancers
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Introduction: Colorectal cancer (CRC) is one of the most common cancers worldwide, often presenting with regional spread to the peritoneum. Peritoneal…”
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Gene Expression Changes Associated with Dedifferentiation in Liposarcoma Predict Overall Survival
Published in Cancers (18-06-2021)“…Up to 10% of well-differentiated liposarcoma (WDLS) progress to dedifferentiated liposarcoma (DDLS). We aimed to identify gene expression changes associated…”
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