Search Results - "Tan, Lay keng"

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets by Deng, Niantao, Goh, Liang Kee, Wang, Hannah, Das, Kakoli, Tao, Jiong, Tan, Iain Beehuat, Zhang, Shenli, Lee, Minghui, Wu, Jeanie, Lim, Kiat Hon, Lei, Zhengdeng, Goh, Glenn, Lim, Qing-Yan, Tan, Angie Lay-Keng, Sin Poh, Dianne Yu, Riahi, Sudep, Bell, Sandra, Shi, Michael M, Linnartz, Ronald, Zhu, Feng, Yeoh, Khay Guan, Toh, Han Chong, Yong, Wei Peng, Cheong, Hyun Cheol, Rha, Sun Young, Boussioutas, Alex, Grabsch, Heike, Rozen, Steve, Tan, Patrick

“…Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most…”
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Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial by Sundar, Raghav, Barr Kumarakulasinghe, Nesaretnam, Huak Chan, Yiong, Yoshida, Kazuhiro, Yoshikawa, Takaki, Miyagi, Yohei, Rino, Yasushi, Masuda, Munetaka, Guan, Jia, Sakamoto, Junichi, Tanaka, Shiro, Tan, Angie Lay-Keng, Hoppe, Michal Marek, Jeyasekharan, Anand D, Ng, Cedric Chuan Young, De Simone, Mark, Grabsch, Heike I, Lee, Jeeyun, Oshima, Takashi, Tsuburaya, Akira, Tan, Patrick

“…To date, there are no predictive biomarkers to guide selection of patients with gastric cancer (GC) who benefit from paclitaxel. Stomach cancer Adjuvant…”
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Genomic Loss of miR-486 Regulates Tumor Progression and the OLFM4 Antiapoptotic Factor in Gastric Cancer by OH, Hue-Kian, LAY-KENG TAN, Angie, PALANISAMY, Nallasivam, MATHIJS VOORHOEVE, P, TAN, Patrick, DAS, Kakoli, OOI, Chia-Huey, DENG, Nian-Tao, BEEHUAT TAN, Lain, BEILLARD, Emmanuel, LEE, Julian, RAMNARAYANAN, Kalpana, RHA, Sun-Young

“…MicroRNAs (miRNA) play pivotal oncogenic and tumor-suppressor roles in several human cancers. We sought to discover novel tumor-suppressor miRNAs in gastric…”
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Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma by Ooi, Wen Fong, Nargund, Amrita M, Lim, Kevin Junliang, Zhang, Shenli, Xing, Manjie, Mandoli, Amit, Lim, Jing Quan, Ho, Shamaine Wei Ting, Guo, Yu, Yao, Xiaosai, Lin, Suling Joyce, Nandi, Tannistha, Xu, Chang, Ong, Xuewen, Lee, Minghui, Tan, Angie Lay-Keng, Lam, Yue Ning, Teo, Jing Xian, Kaneda, Atsushi, White, Kevin P, Lim, Weng Khong, Rozen, Steven G, Teh, Bin Tean, Li, Shang, Skanderup, Anders J, Tan, Patrick

“…Genomic structural variations (SVs) causing rewiring of -regulatory elements remain largely unexplored in gastric cancer (GC). To identify SVs affecting…”
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Transcriptional analysis of immune genes in Epstein–Barr virus-associated gastric cancer and association with clinical outcomes by Sundar, Raghav, Qamra, Aditi, Tan, Angie Lay Keng, Zhang, Shenli, Ng, Cedric Chuan Young, Teh, Bin Tean, Lee, Jeeyun, Kim, Kyoung-Mee, Tan, Patrick

“…Background Epstein–Barr virus-associated gastric cancer (EBVaGC) has traditionally been associated with high expression of PD-L1 and immune infiltration…”
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Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer by Kumar, Vikrant, Ramnarayanan, Kalpana, Sundar, Raghav, Padmanabhan, Nisha, Srivastava, Supriya, Koiwa, Mayu, Yasuda, Tadahito, Koh, Vivien, Huang, Kie Kyon, Tay, Su Ting, Ho, Shamaine Wei Ting, Tan, Angie Lay Keng, Ishimoto, Takatsugu, Kim, Guowei, Shabbir, Asim, Chen, Qingfeng, Zhang, Biyan, Xu, Shengli, Lam, Kong-Peng, Lum, Huey Yew Jeffrey, Teh, Ming, Yong, Wei Peng, So, Jimmy Bok Yan, Tan, Patrick

“…Gastric cancer heterogeneity represents a barrier to disease management. We generated a comprehensive single-cell atlas of gastric cancer (>200,000 cells)…”
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Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer by Huang, Kie Kyon, Ramnarayanan, Kalpana, Zhu, Feng, Srivastava, Supriya, Xu, Chang, Tan, Angie Lay Keng, Lee, Minghui, Tay, Suting, Das, Kakoli, Xing, Manjie, Fatehullah, Aliya, Alkaff, Syed Muhammad Fahmy, Lim, Tony Kiat Hon, Lee, Jonathan, Ho, Khek Yu, Rozen, Steven George, Teh, Bin Tean, Barker, Nick, Chia, Chung King, Khor, Christopher, Ooi, Choon Jin, Fock, Kwong Ming, So, Jimmy, Lim, Wee Chian, Ling, Khoon Lin, Ang, Tiing Leong, Wong, Andrew, Rao, Jaideepraj, Rajnakova, Andrea, Lim, Lee Guan, Yap, Wai Ming, Teh, Ming, Yeoh, Khay Guan, Tan, Patrick

“…Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. We performed (epi)genomic…”
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Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer by Huang, Kie Kyon, Huang, Jiawen, Wu, Jeanie Kar Leng, Lee, Minghui, Tay, Su Ting, Kumar, Vikrant, Ramnarayanan, Kalpana, Padmanabhan, Nisha, Xu, Chang, Tan, Angie Lay Keng, Chan, Charlene, Kappei, Dennis, Göke, Jonathan, Tan, Patrick

“…Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations…”
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Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities by Ho, Shamaine Wei Ting, Sheng, Taotao, Xing, Manjie, Ooi, Wen Fong, Xu, Chang, Sundar, Raghav, Huang, Kie Kyon, Li, Zhimei, Kumar, Vikrant, Ramnarayanan, Kalpana, Zhu, Feng, Srivastava, Supriya, Isa, Zul Fazreen Bin Adam, Anene-Nzelu, Chukwuemeka George, Razavi-Mohseni, Milad, Shigaki, Dustin, Ma, Haoran, Tan, Angie Lay Keng, Ong, Xuewen, Lee, Ming Hui, Tay, Su Ting, Guo, Yu Amanda, Huang, Weitai, Li, Shang, Beer, Michael A, Foo, Roger Sik Yin, Teh, Ming, Skanderup, Anders Jacobsen, Teh, Bin Tean, Tan, Patrick

“…Gastric cancer (GC) comprises multiple molecular subtypes. Recent studies have highlighted mesenchymal-subtype GC (Mes-GC) as a clinically aggressive subtype…”
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Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer by Hou, Qingsong, Wu, Yong Hui, Grabsch, Heike, Zhu, Yansong, Leong, Siew Hong, Ganesan, Kumaresan, Cross, Debra, Tan, Lay Keng, Tao, Jiong, Gopalakrishnan, Veena, Tang, Bor Luen, Kon, Oi Lian, Tan, Patrick

“…Recurrent genomic amplifications and deletions are frequently observed in primary gastric cancers (GC). However, identifying specific oncogenes and tumor…”
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A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers by Yu, Kun, Ganesan, Kumaresan, Tan, Lay Keng, Laban, Mirtha, Wu, Jeanie, Zhao, Xiao Dong, Li, Hongmin, Leung, Carol Ho Wing, Zhu, Yansong, Wei, Chia Lin, Hooi, Shing Chuan, Miller, Lance, Tan, Patrick

“…Successful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing…”
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HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer by Xu, Chang, Ooi, Wen Fong, Qamra, Aditi, Tan, Jing, Chua, Benjamin Yan-Jiang, Ho, Shamaine Wei Ting, Das, Kakoli, Adam Isa, Zul Fazreen, Li, Zhimei, Yao, Xiaosai, Yan, Tingdong, Xing, Manjie, Huang, Kie Kyon, Lin, Joyce Suling, Nandi, Tannistha, Tay, Su Ting, Lee, Ming Hui, Tan, Angie Lay Keng, Ong, Xuewen, Ashktorab, Hassan, Smoot, Duane, Li, Shang, Ng, Shyh-Chang, Teh, Bin Tean, Tan, Patrick

“…Gastric cancer (GC) is a leading cause of cancer mortality. Previous studies have shown that is specifically overexpressed in GC and functionally required for…”
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Comprehensive molecular phenotyping of ARID1A -deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities by Xu, Chang, Huang, Kie Kyon, Law, Jia Hao, Chua, Joy Shijia, Sheng, Taotao, Flores, Natasha M, Pizzi, Melissa Pool, Okabe, Atsushi, Tan, Angie Lay Keng, Zhu, Feng, Kumar, Vikrant, Lu, Xiaoyin, Benitez, Ana Morales, Lian, Benedict Shi Xiang, Ma, Haoran, Ho, Shamaine Wei Ting, Ramnarayanan, Kalpana, Anene-Nzelu, Chukwuemeka George, Razavi-Mohseni, Milad, Abdul Ghani, Siti Aishah Binte, Tay, Su Ting, Ong, Xuewen, Lee, Ming Hui, Guo, Yu Amanda, Ashktorab, Hassan, Smoot, Duane, Li, Shang, Skanderup, Anders Jacobsen, Beer, Michael A, Foo, Roger Sik Yin, Wong, Joel Shi Hao, Sanghvi, Kaushal, Yong, Wei Peng, Sundar, Raghav, Kaneda, Atsushi, Prabhakar, Shyam, Mazur, Pawel Karol, Ajani, Jaffer A, Yeoh, Khay Guan, So, Jimmy Bok-Yan, Tan, Patrick

“…Gastric cancer (GC) is a leading cause of cancer mortality, with being the second most frequently mutated driver gene in GC. We sought to decipher -specific GC…”
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Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer by Nargund, Amrita M, Xu, Chang, Mandoli, Amit, Okabe, Atsushi, Chen, Gao Bin, Huang, Kie Kyon, Sheng, Taotao, Yao, Xiaosai, Teo, Jia Ming Nickolas, Sundar, Raghav, Kok, Yee Jiun, See, Yi Xiang, Xing, Manjie, Li, Zhimei, Yong, Chern Han, Anand, Aparna, A I, Zul Fazreen, Poon, Lai Fong, Ng, Michelle Shu Wen, Koh, Javier Yu Peng, Ooi, Wen Fong, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Grabsch, Heike I, Fullwood, Melissa J, Teh, Tean Bin, Bi, Xuezhi, Kaneda, Atsushi, Li, Shang, Tan, Patrick

“…Mutations in the DNA mismatch repair gene MSH2 are causative of microsatellite instability (MSI) in multiple cancers. Here, we discovered that besides its…”
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Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation by Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T, Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J, Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A, Kappei, Dennis, Kruger, Warren D, Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, Tan, Patrick

“…CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of…”
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An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins by Li, Song, Koe, Chwee Tat, Tay, Su Ting, Tan, Angie Lay Keng, Zhang, Shenli, Zhang, Yingjie, Tan, Patrick, Sung, Wing-Kin, Wang, Hongyan

“…The switch between quiescence and proliferation is central for neurogenesis and its alteration is linked to neurodevelopmental disorders such as microcephaly…”
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Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma by Qamra, Aditi, Xing, Manjie, Padmanabhan, Nisha, Kwok, Jeffrey Jun Ting, Zhang, Shenli, Xu, Chang, Leong, Yan Shan, Lee Lim, Ai Ping, Tang, Qianqao, Ooi, Wen Fong, Suling Lin, Joyce, Nandi, Tannistha, Yao, Xiaosai, Ong, Xuewen, Lee, Minghui, Tay, Su Ting, Keng, Angie Tan Lay, Gondo Santoso, Erna, Ng, Cedric Chuan Young, Ng, Alvin, Jusakul, Apinya, Smoot, Duane, Ashktorab, Hassan, Rha, Sun Young, Yeoh, Khay Guan, Peng Yong, Wei, Chow, Pierce K H, Chan, Weng Hoong, Ong, Hock Soo, Soo, Khee Chee, Kim, Kyoung-Mee, Wong, Wai Keong, Rozen, Steven G, Teh, Bin Tean, Kappei, Dennis, Lee, Jeeyun, Connolly, John, Tan, Patrick

“…Promoter elements play important roles in isoform and cell type-specific expression. We surveyed the epigenomic promoter landscape of gastric adenocarcinoma,…”
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Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation by Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T., Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J., Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A., Kappei, Dennis, Kruger, Warren D., Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, Tan, Patrick

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Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer by Sheng, Taotao, Ho, Shamaine Wei Ting, Ooi, Wen Fong, Xu, Chang, Xing, Manjie, Padmanabhan, Nisha, Huang, Kie Kyon, Ma, Lijia, Ray, Mohana, Guo, Yu Amanda, Sim, Ngak Leng, Anene-Nzelu, Chukwuemeka George, Chang, Mei Mei, Razavi-Mohseni, Milad, Beer, Michael A, Foo, Roger Sik Yin, Sundar, Raghav, Chan, Yiong Huak, Tan, Angie Lay Keng, Ong, Xuewen, Skanderup, Anders Jacobsen, White, Kevin P, Jha, Sudhakar, Tan, Patrick

“…Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been…”
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Erratum: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins by Li, Song, Koe, Chwee Tat, Tay, Su Ting, Tan, Angie Lay Keng, Zhang, Shenli, Zhang, Yingjie, Tan, Patrick, Sung, Wing-Kin, Wang, Hongyan

“…A correction to this article has been published and is linked from the HTML version of this article…”
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