Search Results - "Tan, Kar Wai"

Lymphatic Vessels Are Essential for the Removal of Cholesterol from Peripheral Tissues by SR-BI-Mediated Transport of HDL by Lim, Hwee Ying, Thiam, Chung Hwee, Yeo, Kim Pin, Bisoendial, Radjesh, Hii, Chung Shii, McGrath, Kristine C.Y., Tan, Kar Wai, Heather, Alison, Alexander, J. Steven Jonathan, Angeli, Veronique

“…Removal of cholesterol from peripheral tissues to the bloodstream via reverse cholesterol transport (RCT) is a process of major biological importance. Here we…”
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CYP1A1 Polymorphisms and Risk of Lung Cancer in Non-Smoking Chinese Women: Influence of Environmental Tobacco Smoke Exposure and GSTM1/T1 Genetic Variation by Ng, Daniel P. K., Tan, Kar-Wai, Zhao, Bin, Seow, Adeline

“…Objective: We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an…”
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Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D by Tan, Kar Wai, Chong, Shu Zhen, Wong, Fiona H.S., Evrard, Maximilien, Tan, Sandra Min-Li, Keeble, Jo, Kemeny, D.M., Ng, Lai Guan, Abastado, Jean-Pierre, Angeli, Véronique

“…Lymphangiogenesis is an important physiological response to inflammatory insult, acting to limit inflammation. Macrophages, dendritic cells, and lymphocytes…”
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Expansion of cortical and medullary sinuses restrains lymph node hypertrophy during prolonged inflammation by Tan, Kar Wai, Yeo, Kim Pin, Wong, Fiona H S, Lim, Hwee Ying, Khoo, Kai Ling, Abastado, Jean-Pierre, Angeli, Véronique

“…During inflammation, accumulation of immune cells in activated lymph nodes (LNs), coupled with a transient shutdown in lymphocyte exit, results in dramatic…”
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The DNA damage response induces antigen presenting cell‐like functions in fibroblasts by Tang, Melissa Li Fang, Khan, Muznah Khatoo Nazar, Croxford, John Ludovic, Tan, Kar Wai, Angeli, Veronique, Gasser, Stephan

“…The DNA damage response (DDR) alerts the immune system to the danger posed by DNA damage through the induction of damage‐associated molecular pattern…”
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Standing in the GAP : To formulate a novel radioimmunotherapy regime to improve the long-term outcome in breast cancer by Pock, Ho Liam, Wei Bryan, Teo Yi, Hoon, Tan Puay, Iqbal, Jabed, Ching, Linn Yeh, Tee, Goh Yeow, Wai, Tan Kar, Chong, Toh Han, Wee, Ong Kong, Wei, Yeoh Kheng

“…The new radioimmunotherapeutic regime GAP15R aims to stimulate glucocorticoid-induced TNF-related protein (G) to overcome Treg suppression; add IFN-α (A) to…”
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Hypertonic saline reduces vascular leakage in a mouse model of severe dengue by Tan, Grace Kai Xin, Ng, Jowin Kai Wei, Tan, Kar Wai, Angeli, Veronique, Moochhala, Shabbir, Ooi, Eng Eong, Alonso, Sylvie

“…Dengue (DEN) is a mosquito-borne viral disease and represents a serious public health threat and an economical burden throughout the tropics. Dengue clinical…”
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Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia by Tay, Meng Hwee Daniel, Lim, Swee Yeng Jason, Leong, Yew Fai Ivan, Thiam, Chung Hwee, Tan, Kar Wai, Torta, Federico Tesio, Narayanaswamy, Pradeep, Wenk, Markus, Angeli, Véronique

“…Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that…”
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Novel OX40 and 4-1BB derived spacers enhance CD30 CAR activity and safety in CD30 positive lymphoma models by Kua, Lindsay, Ng, Chee Hoe, Tan, Jin Wei, Tan, Hwee Ching, Seh, Cheah Chen, Wong, Fiona, Ong, Richard, Rooney, Cliona M, Tan, Joel, Chen, Qingfeng, Horak, Ivan D, Tan, Kar Wai, Low, Lionel

“…The chimeric antigen receptor (CAR) derived from the CD30 specific murine antibody, HRS-3, has produced promising clinical efficacy with a favorable safety…”
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Inflammatory lymphangiogenesis: cellular mediators and functional implications by Tan, Kar Wai, Chong, Shu Zhen, Angeli, Véronique

“…In adult mammals, lymphatic vessels have been shown to respond to their environment by undergoing lymphangiogenesis, the formation of new lymphatic vessels…”
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Single Cell Immune Profiling Reveals Distinct T Cell Clones and Functional States in in-Vitro Expanded Cord Blood Derived Gamma Delta T Cells by Tan, Kar Wai, Li, Zhihui, Lai, Joey, Guo, Dianyan, Linn, Yeh Ching, Hwang, William YK, Li, Shang, Eaves, Connie J., Goh, Yeow Tee, Cheung, Alice

“…Gamma-delta (γδ) T cells represent a special class of unconventional T cells defined by their expression of the somatically rearranged T cell receptor (TCR) γ…”
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Determining the Development of Persisters in Extensively Drug-Resistant Acinetobacter baumannii upon Exposure to Polymyxin B-Based Antibiotic Combinations Using Flow Cytometry by Wong, Fiona Hui-Sian, Cai, Yiying, Leck, Hui, Lim, Tze-Peng, Teo, Jocelyn Qi-Min, Lee, Winnie, Koh, Tse Hsien, Tan, Thuan Tong, Tan, Kar Wai, Kwa, Andrea Lay-Hoon

“…Polymyxin B-based combinations are increasingly prescribed as a last-line option against extensively drug-resistant (XDR) It is unknown if such combinations…”
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Abstract P65: Single Cell Profiling Reveals Unique TCR Repertoire and Transcriptomic Signatures of Epstein-Barr Virus-Specific T cells (EBVSTs) Armoured with Chimeric Antigen Receptors (CARs) by Kua, Lindsay, Lim, Ting Wei, Wong, Fiona, Teo, Pei Yun, Low, Lionel, Horak, Ivan, Chen, Jinmiao, Tan, Kar Wai

“…Abstract Allogeneic Epstein-Barr Virus-specific T cells (EBVSTs) have thus far been a safe immunotherapy product in the clinic, with little…”
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Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site by Thoreau, Maxime, Penny, HweiXian Leong, Tan, KarWai, Regnier, Fabienne, Weiss, Julia Miriam, Lee, Bernett, Johannes, Ludger, Dransart, Estelle, Le Bon, Agnès, Abastado, Jean-Pierre, Tartour, Eric, Trautmann, Alain, Bercovici, Nadège

“…Most cancer immunotherapies under present investigation are based on the belief that cytotoxic T cells are the most important anti-tumoral immune cells,…”
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Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation by Tham, Muly, Tan, Kar Wai, Keeble, Jo, Wang, Xiaojie, Hubert, Sandra, Barron, Luke, Tan, Nguan Soon, Kato, Masashi, Prevost-Blondel, Armelle, Angeli, Veronique, Abastado, Jean-Pierre

“…M2 macrophages promote tumor growth and metastasis, but their interactions with specific tumor cell populations are poorly characterized. Using a mouse model…”
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240 Humanized CD30 chimeric antigen receptor T cells with a novel 4–1BB derived spacer have improved activity and safety against CD30-positive lymphomas by Kua, Lindsay, Ng, Chee Hoe, Jin Wei Tan, Ong, Richard, Cheah, Chen Seh, Wong, Fiona, Sim, Don, Horak, Ivan David, Low, Lionel, Tan, Kar Wai

“…BackgroundAutologous T cells expressing chimeric antigen receptors (CARs) against CD30 have demonstrated high clinical efficacy in the treatment of relapsed or…”
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CD8 T Cells Regulate Allergic Contact Dermatitis by Modulating CCR2–Dependent TNF/iNOS–Expressing Ly6C+CD11b+ Monocytic Cells by Chong, Shu Zhen, Tan, Kar Wai, Wong, Fiona H.S., Chua, Yen Leong, Tang, Yafang, Ng, Lai Guan, Angeli, Veronique, Kemeny, David M.

“…Monocytes and their derived cells have critical roles in inflammation and immune defense. However, their function in skin diseases such as allergic contact…”
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Tumor stroma and chemokines control T-cell migration into melanoma following Temozolomide treatment by Tan, Kar Wai, Evrard, Maximilien, Tham, Muly, Hong, Michelle, Huang, Caleb, Kato, Masashi, Prevost-Blondel, Armelle, Donnadieu, Emmanuel, Ng, Lai Guan, Abastado, Jean-Pierre

“…The infiltration of T lymphocytes within tumors is associated with better outcomes in cancer patients, yet current understanding of factors that influence…”
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B7-H3-Targeting Chimeric Antigen Receptors Epstein Barr Virus Specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3 Positive Solid Tumors by Yeo, Siok Ping, Kua, Lindsay, Tan, Jin Wei, Lim, Joanna Kristyn, Wong, Fiona Hs, Santos, May Delos, Poh, Chek Meng, Goh, Angeline Xh, Koh, Xin Yu, Zhou, Xiaohua, Rajarethinam, Ravisankar, Chen, Qingfeng, Her, Zhisheng, Horak, Ivan D, Low, Lionel, Tan, Kar Wai

“…Encouraged by our observations of pronounced B7-H3 protein over-expression in many human solid tumors compared to healthy tissues, we focused on targeting…”
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Abstract P66: Off-The-Shelf Epstein Barr Virus Specific T Cells Armored with B7-H3-Targeting Chimeric Antigen Receptors Is an Effective and Safe Tumor- Agnostic Therapy For B7-H3 Positive Solid Malignancies by Yeo, Siok Ping, Kua, Lindsay, Tan, Jin Wei, Lim, Joanna Kristyn, Wong, Fiona, Santos, May Delos, Poh, Chek Meng, XH, Angeline Goh, Yu Koh, Xin, Zhou, Xiao Hua, R, Rajarethinam, Chen, Qing Feng, Her, Zhisheng, Horak, Ivan D, Low, Lionel, Tan, Kar Wai

“…Abstract In contrast to its limited expression in normal tissues, the B7 homolog 3 protein (B7-H3) is over-expressed in many human tumors, making it an…”
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