Search Results - "Tan, Jonathan K H"

Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis by O'Neill, Helen C, Lim, Hong K, Periasamy, Pravin, Kumarappan, Lavanya, Tan, Jonathan K H, O'Neill, Terence J

“…Spleen stromal lines which support in vitro hematopoiesis are investigated for their lineage origin and hematopoietic support function in vivo. Marker…”
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Murine spleen tissue regeneration from neonatal spleen capsule requires lymphotoxin priming of stromal cells by Tan, Jonathan K H, Watanabe, Takeshi

“…Spleen is a tissue with regenerative capacity, which allows autotransplantation of human spleen fragments to counteract the effects of splenectomy. We now…”
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Characterization of the effect of LPS on dendritic cell subset discrimination in spleen by Griffiths, Kristin L, Tan, Jonathan KH, O'Neill, Helen C

“…The Gram‐negative bacterial endotoxin lipopolysaccharide (LPS) is a potent inflammatory mediator and a leading cause of bacterial sepsis. While LPS is known to…”
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Novel splenic antigen-presenting cells derive from a Lin−c-kitlo progenitor by Periasamy, Pravin, Tan, Jonathan K. H., OˈNeill, Helen C.

“…The spleen contains a novel antigen presenting a cell type which develops from endogenous hematopoietic progenitors. The main DC subsets in murine spleen arise…”
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Investigation of Murine Spleen as a Niche for Hematopoiesis by TAN, Jonathan K. H, O'NEILL, Helen C

“…Spleen as a lymphoid tissue is specialized for monitoring blood and mounting immunity against blood-borne antigens. Antigen-presenting cells present in spleen…”
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Stromal Cell Subsets Directing Neonatal Spleen Regeneration by Tan, Jonathan K. H., Watanabe, Takeshi

“…Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi)…”
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Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity by Tan, Jonathan K. H., O’Neill, Helen C.

“…The model that dendritic cell (DC) “maturation” describes the change from an immature, antigen‐capturing cell to a mature, antigen‐presenting cell is…”
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Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells by Tan, Jonathan K.H., Periasamy, Pravin, O'Neill, Helen C.

“…Hematopoietic cell lineages are best described in terms of distinct progenitors with limited differentiative capacity. To distinguish cell lineages, it is…”
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Artificial engineering of secondary lymphoid organs by Tan, Jonathan K H, Watanabe, Takeshi

“…Secondary lymphoid organs such as spleen and lymph nodes are highly organized immune structures essential for the initiation of immune responses. They display…”
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Concise Review: Dendritic Cell Development in the Context of the Spleen Microenvironment by Tan, Jonathan K. H., O'Neill, Helen C.

“…The dendritic cell (DC) population in spleen comprises a mixture of cells including endogenous DC progenitors, DC precursors migrating in from blood and bone…”
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Haematopoietic stem cells in spleen have distinct differentiative potential for antigen presenting cells by Tan, Jonathan K.H., O’Neill, Helen C.

“…Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes,…”
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Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type by Griffiths, Kristin L., O'Neill, Helen C., Periasamy, Pravin, Hinton, Rebecca A., Hey, Ying-Ying, Petvises, Sawang, Tan, Jonathan K. H.

“…While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not…”
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Redefining Myeloid Cell Subsets in Murine Spleen by Hey, Ying-Ying, Tan, Jonathan K H, O'Neill, Helen C

“…Spleen is known to contain multiple dendritic and myeloid cell subsets, distinguishable on the basis of phenotype, function and anatomical location. As a…”
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Determinants of postnatal spleen tissue regeneration and organogenesis by Tan, Jonathan K. H., Watanabe, Takeshi

“…The spleen is an organ that filters the blood and is responsible for generating blood-borne immune responses. It is also an organ with a remarkable capacity to…”
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Splenic stromal niches support hematopoiesis of dendritic-like cells from precursors in bone marrow and spleen by Periasamy, Pravin, Tan, Jonathan K.H, Griffiths, Kristin L, O'Neill, Helen C

“…Objective The aims of this study are to test the ability of stromal cells from murine spleen to support hematopoiesis, to define the tissue source of…”
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Myelopoiesis in spleen‐producing distinct dendritic‐like cells by Tan, Jonathan K. H., O’Neill, Helen C.

“…Dendritic cells (DC) represent a heterogeneous class of antigen presenting cells (APC). Previously we reported a distinct myeloid dendritic‐like cell present…”
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Identification of a novel antigen cross‐presenting cell type in spleen by Tan, Jonathan K. H., Quah, Ben J. C., Griffiths, Kristin L., Periasamy, Pravin, Hey, Ying‐Ying, O’Neill, Helen C.

“…Antigen‐presenting cells (APC), like dendritic cells (DC), are essential for T‐cell activation, leading to immunity or tolerance. Multiple DC subsets each play…”
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Spleen stroma maintains progenitors and supports long-term hematopoiesis by O'Neill, Helen C, Griffiths, Kristin L, Periasamy, Pravin, Hinton, Rebecca A, Petvises, Sawang, Hey, Ying-ying, Tan, Jonathan K H

“…Hematopoietic stem/progenitor cells (HSPC) differentiate in the context of stromal niches producing cells of multiple lineages. Limited success has been…”
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In vitro haematopoiesis of a novel dendritic-like cell present in murine spleen by Tan, Jonathan K H, O'Neill, Helen C

“…Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets…”
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Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation by Tourle, Karin, Rucinski, Amber, Grainger, Alexander, Limnios, Ioannis J, Gonzalez Ruiz, Macarena, Tan, Jonathan K H

“…The spleen is an immune organ that plays a key role in blood-borne immune responses. The anatomical or functional loss of this tissue increases susceptibility…”
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