Search Results - "Tan, Iris"

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy by Bernardini, Jonathan P, Brouwer, Jason M, Tan, Iris KL, Sandow, Jarrod J, Huang, Shuai, Stafford, Che A, Bankovacki, Aleksandra, Riffkin, Christopher D, Wardak, Ahmad Z, Czabotar, Peter E, Lazarou, Michael, Dewson, Grant

“…The E3 ubiquitin ligase Parkin is a key effector of the removal of damaged mitochondria by mitophagy. Parkin determines cell fate in response to mitochondrial…”
Get full text

VDAC2 enables BAX to mediate apoptosis and limit tumor development by Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant

“…Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential…”
Get full text

Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins by Huang, Allan Shuai, Chin, Hui San, Reljic, Boris, Djajawi, Tirta M., Tan, Iris K. L., Gong, Jia-Nan, Stroud, David A., Huang, David C. S., van Delft, Mark F., Dewson, Grant

“…Intrinsic apoptosis is principally governed by the BCL-2 family of proteins, but some non-BCL-2 proteins are also critical to control this process. To identify…”
Get full text

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove by Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant

“…BAK and BAX are the essential effectors of apoptosis because without them a cell is resistant to most apoptotic stimuli. BAK and BAX undergo conformation…”
Get full text

BAK core dimers bind lipids and can be bridged by them by Cowan, Angus D., Smith, Nicholas A., Sandow, Jarrod J., Kapp, Eugene A., Rustam, Yepy H., Murphy, James M., Brouwer, Jason M., Bernardini, Jonathan P., Roy, Michael J., Wardak, Ahmad Z., Tan, Iris K., Webb, Andrew I., Gulbis, Jacqueline M., Smith, Brian J., Reid, Gavin E., Dewson, Grant, Colman, Peter M., Czabotar, Peter E.

“…BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer…”
Get full text

Glycaemic responses in Asian and non-Asian people with type 2 diabetes initiating insulin glargine 100 units/mL: A patient-level pooled analysis of 16 randomised controlled trials by Chan, Juliana C.N., Bunnag, Pongamorn, Chan, Siew P., Tan, Iris T.I., Tsai, Shih-Tzer, Gao, Ling, Landgraf, Wolfgang

“…•Asian patients with T2D in our cohort had lower BMI and C-peptide than non-Asians.•Asian patients had lower, FPG and starting insulin dose (U/day).•Gla-100…”
Get full text

Dynamic reconfiguration of pro‐apoptotic BAK on membranes by Sandow, Jarrod J, Tan, Iris KL, Huang, Alan S, Masaldan, Shashank, Bernardini, Jonathan P, Wardak, Ahmad Z, Birkinshaw, Richard W, Ninnis, Robert L, Liu, Ziyan, Dalseno, Destiny, Lio, Daisy, Infusini, Giuseppi, Czabotar, Peter E, Webb, Andrew I, Dewson, Grant

“…BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self‐associates to damage mitochondria and…”
Get full text

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis by Alsop, Amber E., Fennell, Stephanie C., Bartolo, Ray C., Tan, Iris K. L., Dewson, Grant, Kluck, Ruth M.

“…During apoptosis, Bak permeabilizes mitochondria after undergoing major conformational changes, including poorly defined N-terminal changes. Here, we…”
Get full text

Democratizing Artificial Intelligence Imaging Analysis With Automated Machine Learning: Tutorial by Thirunavukarasu, Arun James, Elangovan, Kabilan, Gutierrez, Laura, Li, Yong, Tan, Iris, Keane, Pearse A, Korot, Edward, Ting, Daniel Shu Wei

“…Deep learning-based clinical imaging analysis underlies diagnostic artificial intelligence (AI) models, which can match or even exceed the performance of…”
Get full text

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design by Brouwer, Jason M., Lan, Ping, Cowan, Angus D., Bernardini, Jonathan P., Birkinshaw, Richard W., van Delft, Mark F., Sleebs, Brad E., Robin, Adeline Y., Wardak, Ahmad, Tan, Iris K., Reljic, Boris, Lee, Erinna F., Fairlie, W. Douglas, Call, Melissa J., Smith, Brian J., Dewson, Grant, Lessene, Guillaume, Colman, Peter M., Czabotar, Peter E.

“…Certain BH3-only proteins transiently bind and activate Bak and Bax, initiating their oligomerization and the permeabilization of the mitochondrial outer…”
Get full text

Interdisciplinary Approach to Identify and Characterize COVID-19 Misinformation on Twitter: Mixed Methods Study by Isip Tan, Iris Thiele, Cleofas, Jerome, Solano, Geoffrey, Pillejera, Jeanne Genevive, Catapang, Jasper Kyle

“…Studying COVID-19 misinformation on Twitter presents methodological challenges. A computational approach can analyze large data sets, but it is limited when…”
Get full text

Use of Facebook to Serve Information Needs of Persons with Diabetes in the Philippines amid the COVID-19 Pandemic by Isip-Tan, Iris Thiele, Gutierrez, Jerico, Bernardo, Diane Carla

“…The use of Facebook (FB) to share and gather information on diabetes is commonplace but no data is available on its use among Filipinos during the COVID-19…”
Get full text

Relationship of Problematic Internet Use, Fear of Missing Out, Loneliness and Nomophobia among Filipino Nursing Students by Hoseña, Megumi Ayagail, Mallorca, Pamela Remle Irish, Muyot, Yvanna Monique, Tan, Iris Nicole, Calong Calong, Kathyrine, Soriano, Gil P

“…The dominance of technology use has brought growing concerns regarding its influence on human living phenomena such as problematic Internet use, fear of…”
Get full text

A recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibility by Tan, Iris K L, Mackin, Leanne, Wang, Nancy, Papenfuss, Anthony T, Elso, Colleen M, Ashton, Michelle P, Quirk, Fiona, Phipson, Belinda, Bahlo, Melanie, Speed, Terence P, Smyth, Gordon K, Morahan, Grant, Brodnicki, Thomas C

“…More than 25 loci have been linked to type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse, but identification of the underlying genes remains…”
Get full text

Interactive Journal Club: A Learning Method to Enhance Collaboration and Participation among Medical Students by Falcon, Robbi Miguel G., Alcazar, Renne Margaret U., Capistrano, Nhel John L., Catral, Charlene Divine M., Remucal, Mark Joseph R., Buan, Ara Karizza G., Cabungcag, Nica, Escober, Nicole Jazzmine L., Pineda, Ryan Nikkole B., Rocha, Anlene Jane B., Reyes, Nico Alexander L., Isip-Tan, Iris Thiele C.

Get full text

An NZW-Derived Interval on Chromosome 7 Moderates Sialadenitis, But Not Insulitis in Congenic Nonobese Diabetic Mice by Burt, Rachel A, Watkins, Laura, Tan, Iris K. L, Wang, Nancy, Quirk, Fiona, Mackin, Leanne, Morgan, Phillip, Zhang, Jian-Guo, Berzins, Stuart P, Morahan, Grant, Brodnicki, Thomas C

“…Autoimmune lymphocytic infiltration of the salivary glands, termed sialadenitis, is a pathologic feature of Sjögren's syndrome (SjS) that is also prominent in…”
Get full text

Indicators of Accurate Health Information on the Internet on the Use of Momordica Charantia in Diabetes Mellitus by Hernandez, Dan Philip, Isip-Tan, Iris Thiele

“…The increasing use of the Internet as a source of health information makes the accuracy of such information crucial. An example is the use of the widely…”
Get full text

Declining Population Sizes and Loss of Genetic Diversity in Commercial Fishes: A Simple Method for a First Diagnostic by Petit-Marty, Natalia, Liu, Min, Tan, Iris Ziying, Chung, Arthur, Terrasa, Bàrbara, Guijarro, Beatriz, Ordines, Francesc, Ramírez-Amaro, Sergio, Massutí, Enric, Schunter, Celia

“…Exploited fish species may have or are experiencing declines in population sizes coupled with changes in their environmental conditions owing to global change…”
Get full text

Filial Piety, Modernization, and the Challenges of Raising Children for Chinese Immigrants: Quantitative and Qualitative Evidence by Lieber, Eli, Nihira, Kazuo, Mink, Iris Tan

“…This study examines Chinese immigrant parents' perceptions of filial piety. The concept of filial piety is introduced and we discuss the impacts of…”
Get full text

Use of Facebook to Serve Information Needs of Persons with Diabetes amid the COVID-19 Pandemic by Isip-Tan, Iris Thiele, Gutierrez, Jerico, Bernardo, Diane Carla

“…*Visual Abstracts prepared by Dr. Jerico Gutierrez Objectives. The use of Facebook (FB) to share and gather information on diabetes is commonplace but no data…”
Get full text