Search Results - "Tan, Ghee T."

Molecular Docking and Molecular Dynamics Simulation Studies of Triterpenes from Vernonia patula with the Cannabinoid Type 1 Receptor by Afjalus Siraj, Md, Rahman, Md Sajjadur, Tan, Ghee T, Seidel, Veronique

“…A molecular docking approach was employed to evaluate the binding affinity of six triterpenes, namely epifriedelanol, friedelin, α-amyrin, α-amyrin acetate,…”
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Bioassay-Guided Isolation and Identification of Cytotoxic Compounds from Melaleuca quinquenervia Fruits by Raksat, Achara, Atanu, Md Samiul Huq, Mendez, Sheyanne, Zerda, Rafael de la, Sun, Rui, Cheenpracha, Sarot, Wall, Marisa, Simmons, Charles J., Williams, Philip G., Tan, Ghee T., Wongwiwatthananukit, Supakit, Chang, Leng Chee

“…The fruit extract of Melaleuca quinquenervia yielded a total of 19 compounds, including two novel spiro-biflavonoid enantiomers (1a and 1b) and a chalcone…”
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Siamese Crocodile White Blood Cell Extract Inhibits Cell Proliferation and Promotes Autophagy in Multiple Cancer Cell Lines by Phosri, Santi, Jangpromma, Nisachon, Chang, Leng Chee, Tan, Ghee T., Wongwiwatthananukit, Supakit, Maijaroen, Surachai, Anwised, Preeyanan, Payoungkiattikun, Wisarut, Klaynongsruang, Sompong

“…Cancer represents one of the most significant threats to human health on a global scale. Hence, the development of effective cancer prevention strategies, as…”
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Altersolanol B, a fungal tetrahydroanthraquinone, inhibits the proliferation of estrogen receptor-expressing (ER+) human breast adenocarcinoma by modulating PI3K/AKT, p38/ERK MAPK and associated signaling pathways by Siraj, Md Afjalus, Jacobs, Aaron T., Tan, Ghee T.

“…The present study focused on the apoptosis-inducing effects and cellular signal-modulating properties of altersolanol B (AB), a minor fungal…”
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Bioactive Constituents from an Endophytic Fungus, Penicillium polonicum NFW9, Associated with Taxus fauna by Fatima, Nighat, Sripisut, Tawanun, Youn, Ui J, Ahmed, Safia, Ul-Haq, Ihsan, Munoz-Acuna, Ulyana, Simmons, Charles J, Qazi, Muneer A, Jadoon, Muniba, Tan, Ghee T, de Blanco, Esperanza J C, Chang, Leng C

“…Endophytic fungi are being recognized as vital and untapped sources of a variety of structurally novel and unique bioactive secondary metabolites in the field…”
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Solid-phase synthesis of cyclic hexapeptides wollamides A, B and desotamide B by Tsutsumi, Lissa S., Tan, Ghee T., Sun, Dianqing

“…[Display omitted] •Solid-phase synthesis of wollamides A, B and desotamide B has been developed.•Optimization studies toward synthesis of cyclohexapeptides…”
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Siamese Crocodile White Blood Cell Extract Inhibits Cell Proliferation and Promotes Autophagy in Multiple Cancer Cell Lines by Phosri, Santi, Jangpromma, Nisachon, Chang, Leng Chee, Tan, Ghee T, Wongwiwatthananukit, Supakit, Maijaroen, Surachai, Anwised, Preeyanan, Payoungkiattikun, Wisarut, Klaynongsruang, Sompong

“…Cancer represents one of the most significant threats to human health on a global scale. Hence, the development of effective cancer prevention strategies, as…”
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Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs by Tsutsumi, Lissa S, Elmore, John M, Dang, Uyen T, Wallace, Miranda J, Marreddy, Ravikanthreddy, Lee, Robin B, Tan, Ghee T, Hurdle, Julian G, Lee, Richard E, Sun, Dianqing

“…Herein we report the antibacterial structure–activity relationships of cyclic hexapeptide wollamide analogs derived from solid-phase library synthesis…”
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New 3-O-Acyl Betulinic Acids from Strychnos vanprukii Craib by Chien, Nguyen Quyet, Hung, Nguyen Van, Santarsiero, Bernard D, Mesecar, Andrew D, Cuong, Nguyen Manh, Soejarto, D. Doel, Pezzuto, John M, Fong, Harry H. S, Tan, Ghee T

“…Three new betulinic acid derivatives, 3β-O-trans-feruloylbetulinic acid (1), 3β-O-cis-feruloylbetulinic acid (2), and 3β-O-cis-coumaroylbetulinic acid (4),…”
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The Role of Endophytic Fungi in the Anticancer Activity of Morinda citrifolia Linn. (Noni) by Hu, Xinwen, Perry, Brian, da Silva, Vitor Martins, Girmay, Sisay, Wu, Yougen, Tan, Ghee T.

“…We hypothesize that the fungal endophytes of noni may possibly play a role in its overall pharmacological repertoire, especially since the perceived efficacy…”
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Evaluation of Natural Products as Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase by Tan, Ghee T, Pezzuto, John M, Kinghorn, A. Douglas, Hughes, Stephen H

“…Inhibition of human immunodeficiency virus reverse transcriptase is currently considered a useful approach in the prophylaxis and intervention of acquired…”
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Synthesis and Structure-Activity Relationships of Lansine Analogues as Antileishmanial Agents by Pieroni, Marco, Girmay, Sisay, Sun, Dianqing, Sahu, Rajnish, Tekwani, Babu L., Tan, Ghee T.

“…Clear and rational thinking: A series of rationally designed, lansine‐derived carbazoles was synthesized and evaluated for activity against promastigotes and…”
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Apoptotic Anticancer Effect of Alvaradoin E Isolated from Alvaradoa haitiensis by Mi, Qiuwen, Lantvit, Daniel, Reyes-Lim, Eulenia, Chai, Heebyung, Phifer, Sharnelle S, Wani, Mansukh C, Wall, Monroe E, Tan, Ghee T, Cordell, Geoffrey A, Farnsworth, Norman R, Kinghorn, A Douglas, Pezzuto, John M

“…Two anthracenone C -glycosides, alvaradoins E and F, isolated from the leaves of Alvaradoa haitiensis Urb. (Simaroubaceae), were found to have potent…”
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Litsea Species as Potential Antiviral Plant Sources by Guan, Yifu, Wang, Dongying, Tan, Ghee T, Van Hung, Nguyen, Cuong, Nguyen Manh, Pezzuto, John M, Fong, Harry H S, Soejarto, Djaja Doel, Zhang, Hongjie

“…Litsea verticillata Hance (Lauraceae), a Chinese medicine used to treat swelling caused by injury or by snake bites, was the first plant identified by our…”
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Bioactive Sulfated Sesterterpene Alkaloids and Sesterterpene Sulfates from the Marine Sponge Fasciospongia sp by Yao, Guangmin, Kondratyuk, Tamara P, Tan, Ghee T, Pezzuto, John M, Chang, Leng Chee

“…Two new sulfated sesterterpene alkaloids, 19-oxofasciospongine A (3) and fasciospongine C (4), and a new sesterterpene sulfate, 25-hydroxyhalisulfate 9 (5),…”
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An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development by Soejarto, D D, Gyllenhaal, C, Kadushin, M R, Southavong, B, Sydara, K, Bouamanivong, S, Xaiveu, M, Zhang, H-J, Franzblau, S G, Tan, Ghee T, Pezzuto, J M, Riley, M C, Elkington, B G, Waller, D P

“…An ethnobotany-based approach in the selection of raw plant materials to study was implemented. To acquire raw plant materials using ethnobotanical field…”
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Pseudoirroratin A, a New Cytotoxic ent-Kaurene Diterpene from Isodon pseudo-irrorata by ZHANG, Hongjie, FAN, Zhuting, TAN, Ghee T., CHAI, Hee-Byung, PEZZUTO, John M., SUN, Handong, FONG, Harry H. S.

“…A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant…”
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Antimalarial activity of Aspilia pruliseta, a medicinal plant from Uganda by Sebisubi, Fred Musoke, Odyek, Olwa, Anokbonggo, William Wilberforce, Ogwal-Okeng, Jasper, Carcache-Blanco, Esperanza J, Ma, Cuiying, Orjala, Jimmy, Tan, Ghee T

“…Aspilia pruliseta Schweinf. (Asteraceae) is a medicinal plant indigenous to Uganda and the neighboring countries of East Africa. It has been used extensively…”
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HIV-1 and HIV-2 reverse transcriptases: a comparative study of sensitivity to inhibition by selected natural products by Tan, G T, Miller, J F, Kinghorn, A D, Hughes, S H, Pezzuto, J M

“…One hundred and fifty six pure natural products, which had previously been tested against HIV-1 reverse transcriptase, were evaluated for HIV-2 reverse…”
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Cytotoxic Flavone Analogues of Vitexicarpin, a Constituent of the Leaves of Vitex negundo by Díaz, Fredyc, Chávez, Daniel, Lee, Dongho, Mi, Qiuwen, Chai, Hee-Byung, Tan, Ghee T, Kardono, Leonardus B. S, Riswan, Soedarsono, Fairchild, Craig R, Wild, Robert, Farnsworth, Norman R, Cordell, Geoffrey A, Pezzuto, John M, Kinghorn, A. Douglas

“…Bioassay-guided fractionation of the chloroform-soluble extract of the leaves of Vitex negundo led to the isolation of the known flavone vitexicarpin (1),…”
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