Search Results - "Tan, Douglas H."

Cyclization of N-Terminal S-Carbamoylmethylcysteine Causing Loss of 17 Da from Peptides and Extra Peaks in Peptide Maps by Geoghegan, Kieran F, Hoth, Lise R, Tan, Douglas H, Borzilleri, Kris A, Withka, Jane M, Boyd, James G

“…Enzymatic digests of proteins S-alkylated with iodoacetamide may contain peptides with N-terminal S-carbamoylmethylcysteine. These can be partly converted to a…”
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Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors by Letavic, Michael A., Axt, Matt Z., Barberia, John T., Carty, Thomas J., Danley, Dennis E., Geoghegan, Kieran F., Halim, Nadia S., Hoth, Lise R., Kamath, Ajith V., Laird, Ellen R., Lopresti-Morrow, Lori L., McClure, Kim F., Mitchell, Peter G., Natarajan, Vijayalakshmi, Noe, Mark C., Pandit, Jayvardhan, Reeves, Lisa, Schulte, Gayle K., Snow, Sheri L., Sweeney, Francis J., Tan, Douglas H., Yu, Chul H.

“…A series of novel, selective TNF-α converting enzyme inhibitors based on 4-hydroxy and 5-hydroxy pipecolate hydroxamic acid scaffolds is described. The potency…”
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Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor by Hoth, Lise R., Tan, Douglas H., Wang, Ing-Kae, Wengender, Paul A., Thompson, Michelle A., Kamath, Ajith V., Geoghegan, Kieran F.

“…The membrane-anchored metalloproteinase ADAM17 (TNF-α converting enzyme; TACE; EC 3.4.24.86) continues to be an attractive drug target in inflammatory diseases…”
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