Search Results - "Tan, Carina P"

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice by Tan, Carina P, Feng, Yue, Zhou, Yun-Ping, Eiermann, George J, Petrov, Aleksandr, Zhou, Changyou, Lin, Songnian, Salituro, Gino, Meinke, Peter, Mosley, Ralph, Akiyama, Taro E, Einstein, Monica, Kumar, Sanjeev, Berger, Joel P, Mills, Sander G, Thornberry, Nancy A, Yang, Lihu, Howard, Andrew D

“…Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice Carina P. Tan 1…”
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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists by Zhou, Changyou, Tang, Cheng, Chang, Eric, Ge, Min, Lin, Songnian, Cline, Eric, Tan, Carina P., Feng, Yue, Zhou, Yun-Ping, Eiermann, George J., Petrov, Aleksandr, Salituro, Gino, Meinke, Peter, Mosley, Ralph, Akiyama, Taro E., Einstein, Monica, Kumar, Sanjeev, Berger, Joel, Howard, Andrew D., Thornberry, Nancy, Mills, Sander G., Yang, Lihu

“…Systematic structure–activity relationship (SAR) studies of a screening lead led to the discovery of a series of thiazolidinediones (TZDs) as potent GPR40…”
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Discovery of a receptor related to the galanin receptors by Lee, Dennis K, Nguyen, Tuan, O'Neill, Gary P, Cheng, Regina, Liu, Yang, Howard, Andrew D, Coulombe, Nathalie, Tan, Carina P, Tang-Nguyen, Anh-Thi, George, Susan R, O'Dowd, Brian F

“…We report the isolation of a cDNA clone named GPR54, which encodes a novel G protein-coupled receptor (GPCR). A PCR search of rat brain cDNA retrieved a clone…”
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Melanin-Concentrating Hormone Receptor Subtypes 1 and 2: Species-Specific Gene Expression by Tan, Carina P., Sano, Hideki, Iwaasa, Hisashi, Pan, Jie, Sailer, Andreas W., Hreniuk, Donna L., Feighner, Scott D., Palyha, Oksana C., Pong, Sheng-Shung, Figueroa, David J., Austin, Christopher P., Jiang, Michael M., Yu, Hong, Ito, Junko, Ito, Makoto, Ito, Masahiko, Guan, Xiao Ming, MacNeil, Douglas J., Kanatani, Akio, Van der Ploeg, Lex H.T., Howard, Andrew D.

“…To assess the contribution of potential central nervous system pathways implicated in the control of appetite regulation and energy metabolism, it is essential…”
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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats by Shearman, Lauren P., Camacho, Ramon E., Sloan Stribling, D., Zhou, Dan, Bednarek, Maria A., Hreniuk, Donna L., Feighner, Scott D., Tan, Carina P., Howard, Andrew D., Van der Ploeg, Lex H.T., MacIntyre, D.Euan, Hickey, Gerard J., Strack, Alison M.

“…Central administration of the neuropeptide melanin-concentrating hormone (MCH) stimulates feeding in rodents. We studied the effects of intracerebroventricular…”
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Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors by McKee, Karen Kulju, Palyha, Oksana C, Feighner, Scott D, Hreniuk, Donna L, Tan, Carina P, Phillips, Michael S, Smith, Roy G, Van der Ploeg, Lex H. T, Howard, Andrew D

“…GH release is thought to occur under the reciprocal regulation of two hypothalamic peptides, GH releasing hormone (GHRH) and somatostatin, via their engagement…”
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Characterization of the bombesin-like peptide receptor family in primates by Sano, Hideki, Feighner, Scott D, Hreniuk, Donna L, Iwaasa, Hisashi, Sailer, Andreas W, Pan, Jie, Reitman, Marc L, Kanatani, Akio, Howard, Andrew D, Tan, Carina P

“…In mammals, bombesin-like peptides mediate a broad range of physiological functions through binding to three highly conserved G-protein-coupled receptors: the…”
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Ligand Activation Domain of Human Orphan Growth Hormone (GH) Secretagogue Receptor (GHS-R) Conserved from Pufferfish to Humans by Palyha, Oksana C, Feighner, Scott D, Tan, Carina P, McKee, Karen Kulju, Hreniuk, Donna L, Gao, Ying-Duo, Schleim, Klaus D, Yang, Lihu, Morriello, Gregori J, Nargund, Ravi, Patchett, Arthur A, Howard, Andrew D, Smith, Roy G

“…Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH-secretagogue receptor…”
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Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues by Feighner, Scott D, Howard, Andrew D, Prendergast, Kristine, Palyha, Oksana C, Hreniuk, Donna L, Nargund, Ravi, Underwood, Dennis, Tata, James R, Dean, Dennis C, Tan, Carina P, McKee, Karen Kulju, Woods, John W, Patchett, Arthur A, Smith, Roy G, Van der Ploeg, Lex H. T

“…Antibodies raised against an intracellular and extracellular domain of the GH secretagogue receptor (GHS-R) confirmed that its topological orientation in the…”
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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists by Walsh, Shawn P., Severino, Alexandra, Zhou, Changyou, He, Jiafang, Liang, Gui-Bai, Tan, Carina P., Cao, Jin, Eiermann, George J., Xu, Ling, Salituro, Gino, Howard, Andrew D., Mills, Sander G., Yang, Lihu

“…The design, synthesis, and structure–activity relationship (SAR) for a series of β-substituted 3-(4-aryloxy)propanoic acid GPR40 agonists is described…”
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Identification and Characterization of a Second Melanin-Concentrating Hormone Receptor, MCH-2R by Sailer, Andreas W., Sano, Hideki, Zeng, Zhizhen, McDonald, Terrence P., Pan, Jie, Pong, Sheng-Shung, Feighner, Scott D., Tan, Carina P., Fukami, Takehiro, Iwaasa, Hisashi, Hreniuk, Donna L., Morin, Nancy R., Sadowski, Sharon J., Ito, Makoto, Ito, Masahiko, Bansal, Alka, Ky, Betty, Figueroa, David J., Jiang, Qingping, Austin, Christopher P., MacNeil, Douglas J., Ishihara, Akane, Ihara, Masaki, Kanatani, Akio, Lex H. T. Van der Ploeg, Howard, Andrew D., Liu, Qingyun

“…Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated from chum salmon pituitaries. Besides its effects on the aggregation of…”
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Cloning and Characterization of Two Human G Protein-Coupled Receptor Genes (GPR38 and GPR39) Related to the Growth Hormone Secretagogue and Neurotensin Receptors by McKee, Karen Kulju, Tan, Carina P., Palyha, Oksana C., Liu, Jim, Feighner, Scott D., Hreniuk, Donna L., Smith, Roy G., Howard, Andrew D., Van der Ploeg, Lex H.T.

“…The recent cloning of a growth hormone secretagogue receptor (GHS-R) from human pituitary gland and brain identified a third G protein-coupled receptor (GPC-R)…”
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Cloning and Expression of a Novel Neuropeptide Y Receptor by Weinberg, David H., Sirinathsinghji, Dalip J.S., Tan, Carina P., Shiao, Lin-Lin, Morin, Nancy, Rigby, Michael R., Heavens, Robert H., Rapoport, Davida R., Bayne, Marvin L., Cascieri, Margaret A., Strader, Catherine D., Linemeyer, David L., MacNeil, Douglas J.

“…The neuropeptide Y family of peptides, which includes neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP), are found in the central and…”
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Molecular analysis of a new splice variant of the human melanocortin-1 receptor by Tan, Carina P, Kulju McKee, Karen, Weinberg, David H, MacNeil, Tanya, Palyha, Oksana C, Feighner, Scott D, Hreniuk, Donna L, Van Der Ploeg, Lex H.T, MacNeil, Douglas J, Howard, Andrew D

“…The primary hormonal regulator of pigmentation is melanocyte stimulating hormone derived from proopiomelanocortin by proteolytic processing. The melanocortin-1…”
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A Role for the Melanocortin 4 Receptor in Sexual Function by Lex H. T. Van der Ploeg, Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan

“…By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of…”
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Interaction of hepatic microsomal epoxide hydrolase derived from a recombinant baculovirus expression system with an azarene oxide and an aziridine substrate analog by Lacourciere, Gerard M, Vakharia, Vikram N, Tan, Carina P, Morris, Diane I, Edwards, Gerard H, Moos, Malcolm, Armstrong, Richard N

“…A recombinant baculovirus (vEHX) encoding rat hepatic microsomal epoxide hydrolase has been constructed. Infection of Spodoptera frugiperda (Sf9) cells with…”
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Identification of receptors for neuromedin U and its role in feeding by Liu, Qingyun, Howard, Andrew D, Wang, Ruiping, Pong, Sheng-Shung, Mellin, Theodore N, Strack, Alison, Guan, Xiao-Ming, Zeng, Zhizhen, Williams, David L, Feighner, Scott D, Nunes, Christian N, Murphy, Beth, Stair, Judith N, Yu, Hong, Jiang, Qingping, Clements, Michelle K, Tan, Carina P, McKee, Karen K, Hreniuk, Donna L, McDonald, Terrence P, Lynch, Kevin R, Evans, Jilly F, Austin, Christopher P, Caskey, C. Thomas, Van der Ploeg, Lex H. T

“…Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species. It…”
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Transcriptional regulation of the human cholesterol 7.alpha.-hydroxylase gene by Molowa, David T, Chen, William S, Cimis, George M, Tan, Carina P

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Receptor for Motilin Identified in the Human Gastrointestinal System by Feighner, Scott D., Tan, Carina P., McKee, Karen Kulju, Palyha, Oksana C., Hreniuk, Donna L., Pong, Sheng-Shung, Austin, Christopher P., Figueroa, David, MacNeil, Douglas, Cascieri, Margaret A., Nargund, Ravi, Bakshi, Raman, Abramovitz, Mark, Stocco, Rino, Kargman, Stacia, O'Neill, Gary, Lex H. T. Van Der Ploeg, Evans, Jilly, Patchett, Arthur A., Smith, Roy G., Howard, Andrew D.

“…Motilin is a 22-amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by…”
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Molecular Characterization and Expression of Cloned Human Galanin Receptors GALR2 and GALR3 by Kolakowski, Lee F., O'Neill, Gary P., Howard, Andrew D., Broussard, Suzanne R., Sullivan, Kathleen A., Feighner, Scott D., Sawzdargo, Marek, Nguyen, Tuan, Kargman, Stacia, Shiao, Lin‐Lin, Hreniuk, Donna L., Tan, Carina P., Evans, Jilly, Abramovitz, Mark, Chateauneuf, Anne, Coulombe, Nathalie, Ng, Gordon, Johnson, Michael P., Tharian, Anita, Khoshbouei, Habibeh, George, Susan R., Smith, Roy G., O'Dowd, Brian F.

“…: Galanin is a 29‐ or 30‐amino acid peptide with wide‐ranging effects on hormone release, feeding behavior, smooth muscle contractility, and somatosensory…”
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