Search Results - "Tan, Bertrand"

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome by Peng, Zhiyu, Cheng, Yanbing, Tan, Bertrand Chin-Ming, Kang, Lin, Tian, Zhijian, Zhu, Yuankun, Zhang, Wenwei, Liang, Yu, Hu, Xueda, Tan, Xuemei, Guo, Jing, Dong, Zirui, Liang, Yan, Bao, Li, Wang, Jun

“…Sites where RNA editing occurs can be found using RNA-Seq, but false positives confound the data analysis. Peng et al . describe algorithms for accurately…”
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RNA editing of 5‐HT2CR impairs insulin secretion of pancreatic beta cells via altered store‐operated calcium entry by Xie, Ke‐Yun, Chien, Shao‐Ju, Tan, Bertrand Chin‐Ming, Chen, Yun‐Wen

“…Recent studies emphasize the importance of 5‐HT2C receptor (5‐HT2CR) signaling in the regulation of energy homeostasis. The 5‐HT2CR is the only…”
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Actin-related protein 6 facilitates proneural protein-induced gene activation for rapid neural differentiation by Hsiao, Yun-Ling, Chen, Hui-Wen, Chen, Kuan-Han, Tan, Bertrand Chin-Ming, Chen, Chia-Hsiang, Pi, Haiwei

“…Neurogenesis is initiated by basic helix-loop-helix proneural proteins. Here, we show that Actin-related protein 6 (Arp6), a core component of the H2A.Z…”
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RNA editome in rhesus macaque shaped by purifying selection by Chen, Jia-Yu, Peng, Zhiyu, Zhang, Rongli, Yang, Xin-Zhuang, Tan, Bertrand Chin-Ming, Fang, Huaying, Liu, Chu-Jun, Shi, Mingming, Ye, Zhi-Qiang, Zhang, Yong E, Deng, Minghua, Zhang, Xiuqin, Li, Chuan-Yun

“…Understanding of the RNA editing process has been broadened considerably by the next generation sequencing technology; however, several issues regarding this…”
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Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates by Chen, Jia-Yu, Shen, Qing Sunny, Zhou, Wei-Zhen, Peng, Jiguang, He, Bin Z, Li, Yumei, Liu, Chu-Jun, Luan, Xuke, Ding, Wanqiu, Li, Shuxian, Chen, Chunyan, Tan, Bertrand Chin-Ming, Zhang, Yong E, He, Aibin, Li, Chuan-Yun

“…While some human-specific protein-coding genes have been proposed to originate from ancestral lncRNAs, the transition process remains poorly understood. Here…”
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MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2 by Lai, Yi-Hsuan, Liu, Hsuan, Chiang, Wei-Fan, Chen, Ting-Wen, Chu, Lichieh Julie, Yu, Jau-Song, Chen, Shu-Jen, Chen, Hua-Chien, Tan, Bertrand Chin-Ming

“…During neoplastic development, a multitude of changes in genome-encoded information are progressively selected to confer growth and survival advantages to…”
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ADAR1 promotes robust hypoxia signaling via distinct regulation of multiple HIF‐1α‐inhibiting factors by Ma, Chung‐Pei, Liu, Hsuan, Yi‐Feng Chang, Ian, Wang, Wan‐Cheng, Chen, Yi‐Tung, Wu, Shao‐Min, Chen, Hui‐Wen, Kuo, Yu‐Ping, Shih, Chieh‐Tien, Li, Chuan‐Yun, Tan, Bertrand Chin‐Ming

“…Adenosine deaminase acting on RNA (ADAR)‐catalyzed adenosine‐to‐inosine RNA editing is potentially dysregulated in neoplastic progression. However, how this…”
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Subtypes of Histopathologically Classical Aldosterone-Producing Adenomas Yield Various Transcriptomic Signaling and Outcomes by Wu, Vin-Cent, Peng, Kang-Yung, Kuo, Yu-Ping, Liu, Hsuan, Tan, Bertrand Chin-Ming, Lin, Yen-Hung, Lai, Tai-Shuan, Chen, Yung-Ming, Chueh, Jeff S

“…There have been no reports of outcome differences between distinctive subgroups in patients with unilateral primary aldosteronism with histopathologically…”
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Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus by Chen, Yu-Ju, Deng, Shin-Meng, Chen, Hui-Wen, Tsao, Chi-Hui, Chen, Wei-Ting, Cheng, Sin-Jhong, Huang, Hsien-Sung, Tan, Bertrand Chin-Ming, Matzuk, Martin M., Flint, Jonathan, Huang, Guo-Jen

“…The biological mechanisms underpinning learning are unclear. Mounting evidence has suggested that adult hippocampal neurogenesis is involved although a causal…”
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A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans by Yi, Yung-Hsiang, Ma, Tian-Hsiang, Lee, Li-Wei, Chiou, Pey-Tsyr, Chen, Po-Hsiang, Lee, Ching-Ming, Chu, Yu-De, Yu, Hsiang, Hsiung, Kuei-Ching, Tsai, Yi-Tzang, Lee, Chi-Chang, Chang, Yu-Sun, Chan, Shih-Peng, Tan, Bertrand Chin-Ming, Lo, Szecheng J

“…Ribosome biogenesis takes place in the nucleolus, the size of which is often coordinated with cell growth and development. However, how metazoans control…”
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APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism by Chen, Ting-Wen, Lee, Chi-Ching, Liu, Hsuan, Wu, Chi-Sheng, Pickering, Curtis R., Huang, Po-Jung, Wang, Jing, Chang, Ian Yi-Feng, Yeh, Yuan-Ming, Chen, Chih-De, Li, Hsin-Pai, Luo, Ji-Dung, Tan, Bertrand Chin-Ming, Chan, Timothy En Haw, Hsueh, Chuen, Chu, Lichieh Julie, Chen, Yi-Ting, Zhang, Bing, Yang, Chia-Yu, Wu, Chih-Ching, Hsu, Chia-Wei, See, Lai-Chu, Tang, Petrus, Yu, Jau-Song, Liao, Wei-Chao, Chiang, Wei-Fan, Rodriguez, Henry, Myers, Jeffrey N., Chang, Kai-Ping, Chang, Yu-Sun

“…Oral squamous cell carcinoma is a prominent cancer worldwide, particularly in Taiwan. By integrating omics analyses in 50 matched samples, we uncover in…”
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Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication by Tan, Bertrand Chin-Ming, Chien, Cheng-Ting, Hirose, Susumu, Lee, Sheng-Chung

“…Chromatin is suppressive in nature to cellular enzymes that metabolize DNA, mainly due to the inherent inaccessibility of the DNA template. Despite extensive…”
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Nucleolar control by a non‐apoptotic p53‐caspases‐deubiquitinylase axis promotes resistance to bacterial infection by Chen, Po‐Hsiang, Chen, Yi‐Tung, Chu, Tai‐Ying, Ma, Tian‐Hsiang, Wu, Mei‐Hsuan, Lin, Hsi‐Hsien, Chang, Yu‐Sun, Tan, Bertrand Chin‐Ming, Lo, Szecheng J.

“…The nucleolus is best known for its cellular role in regulating ribosome production and growth. More recently, an unanticipated role for the nucleolus in…”
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Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation by Chen, Yi-Tung, Chang, Ian Yi-Feng, Liu, Hsuan, Ma, Chung-Pei, Kuo, Yu-Ping, Shih, Chieh-Tien, Shih, Ying-Hsin, Kang, Lin, Tan, Bertrand Chin-Ming

“…Processing of the eukaryotic transcriptome is a dynamic regulatory mechanism that confers genetic diversity, and splicing and adenosine to inosine (A-to-I) RNA…”
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The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence by Shih, Chieh‐Tien, Chang, Yi‐Feng, Chen, Yi‐Tung, Ma, Chung‐Pei, Chen, Hui‐Wen, Yang, Chang‐Ching, Lu, Juu‐Chin, Tsai, Yau‐Sheng, Chen, Hua‐Chien, Tan, Bertrand Chin‐Ming

“…Summary Cellular senescence is a permanent proliferative arrest triggered by genome instability or aberrant growth stresses, acting as a protective or even…”
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FACT facilitates chromatin transcription by RNA polymerases I and III by Birch, Joanna L, Tan, Bertrand C-M, Panov, Kostya I, Panova, Tatiana B, Andersen, Jens S, Owen-Hughes, Tom A, Russell, Jackie, Lee, Sheng-Chung, Zomerdijk, Joost C B M

“…Efficient transcription elongation from a chromatin template requires RNA polymerases (Pols) to negotiate nucleosomes. Our biochemical analyses demonstrate…”
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Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates by An, Ni A, Ding, Wanqiu, Yang, Xin-Zhuang, Peng, Jiguang, He, Bin Z, Shen, Qing Sunny, Lu, Fujian, He, Aibin, Zhang, Yong E, Tan, Bertrand Chin-Ming, Chen, Jia-Yu, Li, Chuan-Yun

“…Recent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general functions of these events are not well…”
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Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events by Zhang, Shi-Jian, Wang, Chenqu, Yan, Shouyu, Fu, Aisi, Luan, Xuke, Li, Yumei, Sunny Shen, Qing, Zhong, Xiaoming, Chen, Jia-Yu, Wang, Xiangfeng, Chin-Ming Tan, Bertrand, He, Aibin, Li, Chuan-Yun

“…Recent RNA-seq technology revealed thousands of splicing events that are under rapid evolution in primates, whereas the reliability of these events, as well as…”
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Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression by Chen, Yi-Tung, Kan, Chia-Hua, Liu, Hsuan, Liu, Yu-Hao, Wu, Chih-Ching, Kuo, Yu-Ping, Chang, Ian Yi-Feng, Chang, Kai-Ping, Yu, Jau-Song, Tan, Bertrand Chin-Ming

“…Recent findings have implicated long noncoding RNAs (lncRNAs) as pivotal gene regulators for diverse biological processes, despite their lack of protein-coding…”
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Longitudinal High-Throughput Sequencing of the T-Cell Receptor Repertoire Reveals Dynamic Change and Prognostic Significance of Peripheral Blood TCR Diversity in Metastatic Colorectal Cancer During Chemotherapy by Chen, Yi-Tung, Hsu, Hung-Chih, Lee, Yun-Shien, Liu, Hsuan, Tan, Bertrand Chin-Ming, Chin, Chia-Yin, Chang, Ian Yi-Feng, Yang, Chia-Yu

“…Colorectal cancer (CRC) is a major cause of cancer mortality and morbidity. Despite advances in chemotherapy and targeted therapy, unsustainable clinical…”
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