Search Results - "Tan, A."

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers by Mendillo, Marc L., Santagata, Sandro, Koeva, Martina, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan

“…Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model…”
Get full text

Plasma tau in Alzheimer disease by Mattsson, Niklas, Zetterberg, Henrik, Janelidze, Shorena, Insel, Philip S, Andreasson, Ulf, Stomrud, Erik, Palmqvist, Sebastian, Baker, David, Tan Hehir, Cristina A, Jeromin, Andreas, Hanlon, David, Song, Linan, Shaw, Leslie M, Trojanowski, John Q, Weiner, Michael W, Hansson, Oskar, Blennow, Kaj

“…OBJECTIVE:To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology…”
Get full text

HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells by Caslini, Corrado, Hong, Sunhwa, Ban, Yuguang J., Chen, Xi S., Ince, Tan A.

“…Chromatin regulation through histone modifications plays an essential role in coordinated expression of multiple genes. Alterations in chromatin induced by…”
Get full text

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer by Smith, A L, Iwanaga, R, Drasin, D J, Micalizzi, D S, Vartuli, R L, Tan, A-C, Ford, H L

“…The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator,…”
Get full text

An overview of the clinical applications of optical coherence tomography angiography by Tan, A C S, Tan, G S, Denniston, A K, Keane, P A, Ang, M, Milea, D, Chakravarthy, U, Cheung, C M G

“…Optical coherence tomography angiography (OCTA) has emerged as a novel, non-invasive imaging modality that allows the detailed study of flow within the…”
Get full text

Reference-free deconvolution of DNA methylation data and mediation by cell composition effects by Houseman, E Andres, Kile, Molly L, Christiani, David C, Ince, Tan A, Kelsey, Karl T, Marsit, Carmen J

“…Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the…”
Get full text

Secretory autophagy maintains proteostasis upon lysosome inhibition by Solvik, Tina A, Nguyen, Tan A, Tony Lin, Yu-Hsiu, Marsh, Timothy, Huang, Eric J, Wiita, Arun P, Debnath, Jayanta, Leidal, Andrew M

“…The endolysosome system plays central roles in both autophagic degradation and secretory pathways, including the release of extracellular vesicles and…”
Get full text

Anaesthesia for mechanical thrombectomy: a narrative review by Dinsmore, J. E., Tan, A.

“…Summary Stroke is a leading cause of death and disability, and is associated with a huge societal and economic burden. Interventions for the immediate…”
Get full text

Electroconvulsive therapy in a patient with positive anti-NMDA receptor antibodies presenting with isolated psychiatric symptoms: A case report by Yuan, Lu, Tan, A Rui, Zhang, Jun

Get full text

A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells by Petrocca, Fabio, Altschuler, Gabriel, Tan, Shen Mynn, Mendillo, Marc L., Yan, Haoheng, Jerry, D. Joseph, Kung, Andrew L., Hide, Winston, Ince, Tan A., Lieberman, Judy

“…Basal-like triple-negative breast cancers (TNBCs) have poor prognosis. To identify basal-like TNBC dependencies, a genome-wide siRNA lethality screen compared…”
Get full text

Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases by Sharma, Niti, Tan, Mario A, An, Seong Soo A

“…Phytosterols constitute a class of natural products that are an important component of diet and have vast applications in foods, cosmetics, and herbal…”
Get full text

Unconventional secretion: cargo channeling by TMED10 by Nguyen, Tan A., Debnath, Jayanta

Get full text

The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease by Tan, Jing Zhi A., Gleeson, Paul A.

“…Alzheimer's disease (AD) is characterized by progressive accumulation of misfolded proteins, which form senile plaques and neurofibrillary tangles, and the…”
Get full text

Of Mice and Women: A Comparative Tissue Biology Perspective of Breast Stem Cells and Differentiation by Dontu, Gabriela, Ince, Tan A.

“…Tissue based research requires a background in human and veterinary pathology, developmental biology, anatomy, as well as molecular and cellular biology. This…”
Get full text

Meta-analysis of endoscopic submucosal dissection versus endoscopic mucosal resection for tumors of the gastrointestinal tract by Cao, Y, Liao, C, Tan, A, Gao, Y, Mo, Z, Gao, F

“…Endoscopic submucosal dissection (ESD) has been developed to overcome the limitations of endoscopic mucosal resection (EMR). We aimed to compare the outcomes…”
Get more information

Spectral Signatures of Protonated Noble Gas Clusters of Ne, Ar, Kr, and Xe: From Monomers to Trimers by Tan, Jake A, Kuo, Jer-Lai

“…The structures and spectral features of protonated noble gas clusters are examined using a first principles approach. Protonated noble gas monomers (NgH ) and…”
Get full text

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules by Tulpule, Asmin, Guan, Juan, Neel, Dana S., Allegakoen, Hannah R., Lin, Yone Phar, Brown, David, Chou, Yu-Ting, Heslin, Ann, Chatterjee, Nilanjana, Perati, Shriya, Menon, Shruti, Nguyen, Tan A., Debnath, Jayanta, Ramirez, Alejandro D., Shi, Xiaoyu, Yang, Bin, Feng, Siyu, Makhija, Suraj, Huang, Bo, Bivona, Trever G.

“…Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to…”
Get full text

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study by Adams, S., Schmid, P., Rugo, H.S., Winer, E.P., Loirat, D., Awada, A., Cescon, D.W., Iwata, H., Campone, M., Nanda, R., Hui, R., Curigliano, G., Toppmeyer, D., O’Shaughnessy, J., Loi, S., Paluch-Shimon, S., Tan, A.R., Card, D., Zhao, J., Karantza, V., Cortés, J.

“…Treatment options for previously treated metastatic triple-negative breast cancer (mTNBC) are limited. In cohort A of the phase II KEYNOTE-086 study, we…”
Get full text

LC3-dependent EV loading and secretion (LDELS) promotes TFRC (transferrin receptor) secretion via extracellular vesicles by Gardner, Jackson O., Leidal, Andrew M., Nguyen, Tan A., Debnath, Jayanta

“…LC3-dependent EV loading and secretion (LDELS) is a secretory autophagy pathway in which the macroautophagy/autophagy machinery facilitates the packaging of…”
Get full text

A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer by Omar, Mohamed, Harrell, J Chuck, Tamimi, Rulla, Marchionni, Luigi, Erdogan, Cihat, Nakshatri, Harikrishna, Ince, Tan A

“…Despite evidence indicating the dominance of cell-of-origin signatures in molecular tumor patterns, translating these genome-wide patterns into actionable…”
Get full text