Search Results - "Tamura, Tomonori"

Chemical biology tools for imaging-based analysis of organelle membranes and lipids by Tamura, Tomonori, Hamachi, Itaru

“…Membrane biology studies have revealed that in addition to providing structural support for compartment formation and membrane protein function, subcellular…”
Get full text

Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins by Tamura, Tomonori, Takato, Mikiko, Shiono, Keiya, Hamachi, Itaru

“…The precise characterization of organellar proteomes is essential for deciphering a variety of cellular functions at the molecular level. We here report a…”
Get full text

Chemical Profiling of the Endoplasmic Reticulum Proteome Using Designer Labeling Reagents by Fujisawa, Alma, Tamura, Tomonori, Yasueda, Yuki, Kuwata, Keiko, Hamachi, Itaru

“…The endoplasmic reticulum (ER) is an organelle that performs a variety of essential cellular functions via interactions with other organelles. Despite its…”
Get full text

Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells by Amaike, Kazuma, Tamura, Tomonori, Hamachi, Itaru

“…Endogenous protein labeling is one of the most invaluable methods for studying the bona fide functions of proteins in live cells. However, multi-molecular…”
Get more information

Imaging and Profiling of Proteins under Oxidative Conditions in Cells and Tissues by Hydrogen-Peroxide-Responsive Labeling by Zhu, Hao, Tamura, Tomonori, Fujisawa, Alma, Nishikawa, Yuki, Cheng, Rong, Takato, Mikiko, Hamachi, Itaru

“…Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) can inflict damage to biomolecules under oxidative stress and also act as signaling molecules at…”
Get full text

Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors by Ueda, Tsuyoshi, Tamura, Tomonori, Hamachi, Itaru

“…Because of its critical roles in regulating cellular signal transduction, the molecular chaperone heat-shock protein 90 (Hsp90) has become a novel therapeutic…”
Get full text

Ligand-directed tosyl chemistry for protein labeling in vivo by Hamachi, Itaru, Tsukiji, Shinya, Miyagawa, Masayoshi, Takaoka, Yousuke, Tamura, Tomonori

“…Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl…”
Get full text

Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide by Tamura, Tomonori, Ueda, Tsuyoshi, Goto, Taiki, Tsukidate, Taku, Shapira, Yonatan, Nishikawa, Yuki, Fujisawa, Alma, Hamachi, Itaru

“…Selective modification of native proteins in live cells is one of the central challenges in recent chemical biology. As a unique bioorthogonal approach,…”
Get full text

Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N‑Acyl‑N‑alkyl Sulfonamide Warhead by Ueda, Tsuyoshi, Tamura, Tomonori, Kawano, Masaharu, Shiono, Keiya, Hobor, Fruzsina, Wilson, Andrew J, Hamachi, Itaru

“…Protein–protein interactions (PPIs) intimately govern various biological processes and disease states and therefore have been identified as attractive…”
Get full text

Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody by Hayashi, Takahiro, Yasueda, Yuki, Tamura, Tomonori, Takaoka, Yousuke, Hamachi, Itaru

“…A general technique for introducing biophysical probes into selected receptors in their native environment is valuable for the study of their structure,…”
Get full text

Development of 1.5 THz Photon Detectors for Terahertz Intensity Interferometry by Niwa, Ayako, Matsuo, Hiroshi, Ezawa, Hajime, Koseki, Tomohiro, Tamura, Tomonori

“…We propose Terahertz Intensity Interferometry (TII) to realize high angular resolution observations above 1 THz. TII uses fast detectors and readout circuits…”
Get full text

Native FKBP12 Engineering by Ligand-Directed Tosyl Chemistry: Labeling Properties and Application to Photo-Cross-Linking of Protein Complexes in Vitro and in Living Cells by Tamura, Tomonori, Tsukiji, Shinya, Hamachi, Itaru

“…The ability to modify target “native” (endogenous) proteins selectively in living cells with synthetic molecules should provide powerful tools for chemical…”
Get full text

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides by Shindo, Naoya, Fuchida, Hirokazu, Sato, Mami, Watari, Kosuke, Shibata, Tomohiro, Kuwata, Keiko, Miura, Chizuru, Okamoto, Kei, Hatsuyama, Yuji, Tokunaga, Keisuke, Sakamoto, Seiichi, Morimoto, Satoshi, Abe, Yoshito, Shiroishi, Mitsunori, Caaveiro, Jose M. M., Ueda, Tadashi, Tamura, Tomonori, Matsunaga, Naoya, Nakao, Takaharu, Koyanagi, Satoru, Ohdo, Shigehiro, Yamaguchi, Yasuchika, Hamachi, Itaru, Ono, Mayumi, Ojida, Akio

“…Irreversible inhibition of disease-associated proteins with small molecules is a powerful approach for achieving increased and sustained pharmacological…”
Get full text

Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules by Yasueda, Yuki, Tamura, Tomonori, Hamachi, Itaru

“…Characterization of a nuclear proteome is a prerequisite for understanding a variety of cellular functions at the molecular level. Here, we report a novel…”
Get full text

Semisynthetic Lectin–4-Dimethylaminopyridine Conjugates for Labeling and Profiling Glycoproteins on Live Cell Surfaces by Hayashi, Takahiro, Sun, Yedi, Tamura, Tomonori, Kuwata, Keiko, Song, Zhining, Takaoka, Yousuke, Hamachi, Itaru

“…Glycoproteins on cell surfaces play important roles in biological processes, including cell–cell interaction/signaling, immune response, and cell…”
Get full text

Contribution to crustal strain accumulation of minor faults: a case study across the Niigata–Kobe Tectonic Zone, Japan by Tamura, Tomonori, Oohashi, Kiyokazu, Otsubo, Makoto, Miyakawa, Ayumu, Niwa, Masakazu

“…Recent global navigation satellite system (GNSS) data for the Japanese Islands have revealed a high-strain-rate region suggesting the existence of a region of…”
Get full text

Y chromosome analysis for common surnames in the Japanese male population by Ochiai, Eriko, Osawa, Motoki, Satoh, Shiori, Tamura, Tomonori, Nakatome, Masato, Kaneko, Yu, Kakimoto, Yu, Minaguchi, Kiyoshi

“…For many years of Japan's long history, Japanese surnames have been handed down patrilineally. This study investigated relations between major surnames and Y…”
Get full text

Fluorophore Labeling of Native FKBP12 by Ligand-Directed Tosyl Chemistry Allows Detection of Its Molecular Interactions in Vitro and in Living Cells by Tamura, Tomonori, Kioi, Yoshiyuki, Miki, Takayuki, Tsukiji, Shinya, Hamachi, Itaru

“…Introducing synthetic fluorophores into specific endogenous proteins and analyzing their function in living cells are a great challenge in chemical biology…”
Get full text

In Situ Construction of Protein-Based Semisynthetic Biosensors by Ueda, Tsuyoshi, Tamura, Tomonori, Hamachi, Itaru

“…Chemically constructed biosensors consisting of a protein scaffold and an artificial small molecule have recently been recognized as attractive analytical…”
Get full text

Evaluation of advanced multiplex short tandem repeat systems in pairwise kinship analysis by Tamura, Tomonori, Osawa, Motoki, Ochiai, Eriko, Suzuki, Takanori, Nakamura, Takashi

“…Highlights • The PowerPlex Fusion, GlobalFiler, and PowerPlex 21 are useful for sibship testing. • The advanced systems less effectively dealt with the…”
Get full text