Search Results - "Tamura, Seiji"

Signal Fluctuation and Neutron Source in Inverse Kinetics Method for Reactivity Measurement in the Sub-critical Domain by TAMURA, Seiji

“…This paper presents numerical experiments on reactivity measurement by the inverse kinetics method in the sub-critical domain or at low power. The increase in…”
Get full text

Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models by Kohara, Atsuyuki, Takahashi, Masayasu, Yatsugi, Shin-ichi, Tamura, Seiji, Shitaka, Yoshitsugu, Hayashibe, Satoshi, Kawabata, Shigeki, Okada, Masamichi

“…Abstract We describe in vitro properties and in vivo neuroprotective effects of a newly synthesized, high-affinity, selective allosteric metabotropic glutamate…”
Get full text

Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1 by Kohara, Atsuyuki, Toya, Takashi, Tamura, Seiji, Watabiki, Tomonari, Nagakura, Yukinori, Shitaka, Yoshitsugu, Hayashibe, Satoshi, Kawabata, Shigeki, Okada, Masamichi

“…Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders…”
Get more information

Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X2/3 receptor function and exerts an analgesic effect in pain models by Kakimoto, Shuichiro, Nagakura, Yukinori, Tamura, Seiji, Watabiki, Tomonari, Shibasaki, Kumiko, Tanaka, Shohei, Mori, Masamichi, Sasamata, Masao, Okada, Masamichi

“…The P2X2/3 receptor has an important role in the nociceptive transmission. Minodronic acid is a third third-generation bisphosphonate and a potent inhibitor of…”
Get full text

Improved Optical Properties of Transparent Low-Emissivity Coatings Using an Asymmetrical Structure Containing Two Silver-Alloy Layers by Chiba, Kiyoshi, Tamura, Seiji, Akada, Naoya

Get full text

Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models by Kohara, Atsuyuki, Nagakura, Yukinori, Kiso, Tetsuo, Toya, Takashi, Watabiki, Tomonari, Tamura, Seiji, Shitaka, Yoshitsugu, Itahana, Hirotsune, Okada, Masamichi

“…Metabotropic glutamate receptor 1 (mGlu 1 receptor) has been suggested to play an important role in pain transmission. In this study, the effects of a…”
Get full text

Signal Fluctuation and Neutron Source in Inverse Kinetics Method for Reactivity Measurement in the Sub-critical Domain by TAMURA, Seiji

“…This paper presents numerical experiments on reactivity measurement by the inverse kinetics method in the sub-critical domain or at low power. The increase in…”
Get full text

Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: Comparison with duloxetine and amitriptyline by Murai, Nobuhito, Tsukamoto, Mina, Tamura, Seiji, Aoki, Toshiaki, Matsuoka, Nobuya

“…The (+)-isomer of indeloxazine AS1069562 exerts multiple pharmacological actions including the inhibition of serotonin (5-HT) and norepinephrine reuptake and…”
Get full text

Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists by Oka, Hiromasa, Yonezawa, Koichi, Kamikawa, Akio, Ikegai, Kazuhiro, Asai, Norio, Shirakami, Shohei, Miyamoto, Satoshi, Watanabe, Toshihiro, Kiso, Tetsuo, Takemoto, Yukihiro, Tamura, Seiji, Kuramochi, Takahiro

“…[Display omitted] A new series of transient receptor potential vanilloid type 1 (TRPV1) antagonists were designed and synthesized from…”
Get full text

AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover by Murai, Nobuhito, Aoki, Toshiaki, Tamura, Seiji, Sekizawa, Toshihiro, Kakimoto, Shuichiro, Tsukamoto, Mina, Oe, Tomoya, Enomoto, Ryugo, Hamakawa, Nozomu, Matsuoka, Nobuya

“…AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment…”
Get more information

AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy by Murai, Nobuhito, Aoki, Toshiaki, Tamura, Seiji, Yamamoto, Hiroko, Hamakawa, Nozomu, Matsuoka, Nobuya

“…AS1069562 is the (+)-isomer of indeloxazine, which had been clinically used as a cerebral activator for the treatment of cerebrovascular diseases with…”
Get full text

AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain by Murai, Nobuhito, Takeshita, Nobuaki, Nishigaki, Fusako, Irie, Megumi, Tamura, Seiji, Aoki, Toshiaki, Matsuoka, Nobuya

“…Objectives: The (+)-isomer of indeloxazine AS1069562 has multiple pharmacological actions, such as serotonin (5-HIT) and norepinephrine (NE) reuptake…”
Get full text

Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models by Kakimoto, Shuichiro, Nagakura, Yukinori, Tamura, Seiji, Watabiki, Tomonari, Shibasaki, Kumiko, Tanaka, Shohei, Mori, Masamichi, Sasamata, Masao, Okada, Masamichi

“…The P2X(2/3) receptor has an important role in the nociceptive transmission. Minodronic acid is a third third-generation bisphosphonate and a potent inhibitor…”
Get full text

Lipid peroxidation, antioxidative enzyme activities, and cytosolic free calcium levels in rat hippocampus-derived cells exposed to free radicals by Tamura, S. (Tokyo Univ. (Japan)), Takanohashi, A, Bonkobara, M, Matsuki, N, Onodera, T, Ono, K

“…To elucidate mechanisms of free radical-induced neuronal cell death, lipid peroxidation measured as thiobarbituric acid-reactive substances (TBARS), three…”
Get full text

Neurometer measurement of current stimulus threshold in rats by Kiso, T, Nagakura, Y, Toya, T, Matsumoto, N, Tamura, S, Ito, H, Okada, M, Yamaguchi, T

“…We examined the current stimulus threshold in rats with the Neurometer, a device used clinically for measuring perception and pain thresholds. Although many…”
Get more information

The effect of suramin on mechanical allodynia developing in melanoma-implanted mice by Yukinori Nagakura, Tomonari Watabiki, Seiji Tamura, Shuicbirou Kakimoto, Yukihiro Takemoto, Fumikazu Wanibuchi, Masamichi Okada, Tokio Yamaguchi

“…Suramin has been extensively evaluated as an anti-cancer agent. Interestingly, it has been shown that it exerts an analgesic effect in hormone-refractory…”
Get full text

高速液体クロマトグラフィー(HPLC)によるウマ赤血球および骨格筋内リン脂質過酸化物の検出(短報) by 松木, 直章, 田村, 誠司, 小野, 憲一郎, 亘, 敏広, 後飯塚, 僚, 高木, 茂美, 長谷川, 篤彦

“…ウマ赤血球および骨格筋内のリン脂質過酸化物を順相HPLCにより測定した. リン脂質分画についてそれぞれ233nm(共役二重結合の最大吸光波長)および206nm(リン脂質の吸光波長)で同時に検出・記録し, 得られたピーク面積の比を求めることでリン脂質過酸化物量の指標を得ることができた. また,…”
Get full text

運動員荷時のウマ骨格筋および赤血球リン脂質過酸化反応 by 松木, 直章, 田村, 誠司, 小野, 憲一郎, 亘, 敏広, 後飯塚, 僚, 山野辺, 啓, 平賀, 敦, 久保, 勝義, 高木, 茂美, 長谷川, 篤彦, 鈴木, 直義

“…ウマの運動に伴う骨格筋障害および溶血の発現と膜リン脂質過酸化反応との関連を明らかにするため, 運動負荷前後の中臀筋生検試料および赤血球について, リン脂質各分画の過酸化物, 遊離マロンジアルデヒド(MDA)および蛋白結合MDAを定量し, その変動を観察した…”
Get full text

Exercise-induced phospholipid degradation in the equine skeletal muscle and erythrocytes by Matsuki, N. (Tokyo Univ. (Japan). Faculty of Agriculture), Tamura, S, Ono, K, Watari, T, Goitsuka, R, Yamanobe, A, Hiraga, A, Kubo, K, Takagi, S, Hasegawa, A, Suzuki, N

“…To understand the pathogenesis of equine exercise-induced myopathies and hemolysis, changes of phospholipid peroxidation products in the equine middle gluteal…”
Get full text

The High-Performance Liquid Chromatographic Analysis for the Peroxidized Phospholipids in Equine Erythrocytes and Skeletal Muscle by MATSUKI, Naoaki, TAMURA, Seiji, ONO, Kenichiro, WATARI, Toshihiro, GOITSUKA, Ryo, TAKAGI, Sigeyoshi, HASEGAWA, Atsuhiko

“…The exercise-induced hemolysis and acute myopathy so called "typing-up syndrome" in horses have been thought to be related to the free radical mediated lipid…”
Get full text