Search Results - "Tampe, R"

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level by Zhu, Rong, Canena, Daniel, Sikora, Mateusz, Klausberger, Miriam, Seferovic, Hannah, Mehdipour, Ahmad Reza, Hain, Lisa, Laurent, Elisabeth, Monteil, Vanessa, Wirnsberger, Gerald, Wieneke, Ralph, Tampé, Robert, Kienzl, Nikolaus F., Mach, Lukas, Mirazimi, Ali, Oh, Yoo Jin, Penninger, Josef M., Hummer, Gerhard, Hinterdorfer, Peter

“…Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron variant. We report that the Spike trimer acts as a highly dynamic molecular…”
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The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation by Koch, J, Tampé, R

“…A challenging task for the adaptive immune system of vertebrates is to identify and eliminate intracellular antigens. Therefore a highly specialized antigen…”
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Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level by Zhu, Rong, Canena, Daniel, Sikora, Mateusz, Klausberger, Miriam, Seferovic, Hannah, Mehdipour, Ahmad Reza, Hain, Lisa, Laurent, Elisabeth, Monteil, Vanessa, Wirnsberger, Gerald, Wieneke, Ralph, Tampé, Robert, Kienzl, Nikolaus F., Mach, Lukas, Mirazimi, Ali, Oh, Yoo Jin, Penninger, Josef M., Hummer, Gerhard, Hinterdorfer, Peter

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Allosteric Crosstalk between Peptide-Binding, Transport, and ATP Hydrolysis of the ABC Transporter TAP by Gorbulev, Stanislav, Abele, Rupert, Tampé, Robert

“…The transporter associated with antigen processing (TAP) is essential for intracellular transport of protein fragments into the endoplasmic reticulum for…”
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Function of the transport complex TAP in cellular immune recognition by Abele, Rupert, Tampé, Robert

“…The transporter associated with antigen processing (TAP) is essential for peptide loading onto major histocompatibility complex (MHC) class I molecules by…”
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Immune escape of melanoma: First evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway by SELIGER, Barbara, RITZ, Ulrike, ABELE, Rupert, BOCK, Michaela, TAMPE, Robert, SUTTER, Gert, DREXLER, Ingo, HUBER, Christoph, FERRONE, Soldano

“…Sequence analyses of the transporter associated with antigen processing (TAP) in tumor cell lines with deficient MHC class I surface expression identified a bp…”
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'Traceless' tracing of proteins - high-affinity trans-splicing directed by a minimal interaction pair by Braner, M, Kollmannsperger, A, Wieneke, R, Tampé, R

“…Protein trans-splicing mediated by split inteins is a powerful technique for site-specific protein modification. Despite recent developments there is still an…”
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A Metal-Chelating Microscopy Tip as a New Toolbox for Single-Molecule Experiments by Atomic Force Microscopy by Schmitt, Lutz, Ludwig, Markus, Gaub, Hermann E., Tampé, Robert

“…In recent years, the atomic force microscope (AFM) has contributed much to our understanding of the molecular forces involved in various high-affinity…”
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Characterization of a transport activity for long-chain peptides in barley mesophyll vacuoles by Ramos, Magali Schnell, Abele, Rupert, Nagy, Réka, Grotemeyer, Marianne Suter, Tampé, Robert, Rentsch, Doris, Martinoia, Enrico

“…The plant vacuole is the largest compartment in a fully expanded plant cell. While only very limited metabolic activity can be observed within the vacuole, the…”
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Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing by Khoo, K. K., Galleano, I., Gasparri, F., Wieneke, R., Harms, H., Poulsen, M. H., Chua, H. C., Wulf, M., Tampé, R., Pless, S. A.

“…Manipulation of proteins by chemical modification is a powerful way to decipher their function. However, most ribosome-dependent and semi-synthetic methods…”
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Nanomolar affinity protein trans-splicing monitored in real-time by fluorophore-quencher pairs by Braner, M, Wieneke, R, Tampé, R

“…High background originating from non-reacted, 'always-on' fluorescent probes remains a key unsolved problem in life science since washing procedures are not…”
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Vapor Phase Exchange of Self-Assembled Monolayers for Engineering of Biofunctional Surfaces by Kankate, L, Aguf, A, Großmann, H, Schnietz, M, Tampé, R, Turchanin, A, Gölzhäuser, A

“…We show that 4′-nitro-1,1′-biphenyl-4-thiol self-assembled monolayers (NBPT SAMs) on gold can be exchanged with 11-(mercapto­undecyl)­triethylene glycol…”
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Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding by Neumann, Lars, Tampé, Robert

“…The transporter associated with antigen processing (TAP) plays a key role in the class I major histocompatibility complex (MHC) mediated immune surveillance…”
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A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes by Ortmann, Bodo, Copeman, James, Lehner, Paul J., Sadasivan, Bhanu, Herberg, Jethro A., Grandea, Andeas G., Riddell, Stanley R., Tampé, Robert, Spies, Thomas, Trowsdale, John, Cresswell, Peter

“…Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact with the…”
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Molecular Mechanism and Structural Aspects of Transporter Associated with Antigen Processing Inhibition by the Cytomegalovirus Protein US6 by Kyritsis, Christoph, Gorbulev, Stanislav, Hutschenreiter, Silke, Pawlitschko, Kurt, Abele, Rupert, Tampé, Robert

“…The human cytomegalovirus (HCMV) has evolved a set of elegant strategies to evade host immunity. The HCMV-encoded type I glycoprotein US6 inhibits peptide…”
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Specificity of the proteasome and the TAP transporter by Uebel, Stephan, Tampé, Robert

“…The generation of antigenic peptides and their transport across the membrane of the endoplasmic reticulum for assembly with MHC class I molecules are essential…”
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A viral inhibitor of peptide transporters for antigen presentation by Früh, Klaus, Ahn, Kwangseog, Djaballah, Hakim, Sempé, Pascal, van Endert, Peter M, Tampé, Robert, Peterson, Per A, Yang, Young

“…Cytotoxic T lymphocytes lyse target cells after T-cell-receptor-mediated recognition of class I major histocompatibility complex molecules presenting peptides…”
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Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies by Klein, A, Hank, S, Raulf, A, Joest, E F, Tissen, F, Heilemann, M, Wieneke, R, Tampé, R

“…Accurate labeling of endogenous proteins for advanced light microscopy in living cells remains challenging. Nanobodies have been widely used for antigen…”
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Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10 by ZEIDLER, R, EISSNER, G, MEISSNER, P, UEBEL, S, TAMPE, R, LAZIS, S, HAMMERSCHMIDT, W

“…Virally infected cells degrade intracellular viral proteins proteolytically and present the resulting peptides in association with major histocompatibility…”
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Recognition Principle of the TAP Transporter Disclosed by Combinatorial Peptide Libraries by Uebel, Stephan, Kraas, Wolfgang, Kienle, Stefan, Wiesmuller, Karl-Heinz, Jung, Gunther, Tampe, Robert

“…Transport of peptides across the membrane of the endoplasmic reticulum for assembly with MHC class I molecules is an essential step in antigen presentation to…”
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