Occurrence of Campylobacter spp. in Swedish calves, common sequence types and antibiotic resistance patterns

Occurrence of Campylobacter spp. in Swedish calves, common sequence types and antibiotic resistance patterns

Aims Cattle are the second most important cause of human campylobacteriosis, after poultry, but there are knowledge gaps regarding Campylobacter in cattle. This study examined the occurrence of Campylobacter, the species present, sequence types and antibiotic resistance in Swedish cattle. Methods an...

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Bibliographic Details
Published in:Journal of applied microbiology Vol. 130; no. 6; pp. 2111 - 2122
Main Authors: Hansson, I., Tamminen, L.‐M., Frosth, S., Fernström, L.‐L., Emanuelson, U., Boqvist, S.
Format: Journal Article
Language:English
Published: England Oxford University Press 01-06-2021
John Wiley and Sons Inc
Subjects:
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bedding
Calves
Campylobacter
Campylobacter hyointestinalis
Campylobacter jejuni
Campylobacteriosis
Cattle
cgMLST
Ciprofloxacin
Clinical Science
Drug resistance
Farms
Gene sequencing
Genomes
Klinisk vetenskap
Microbiology
Mikrobiologi
Nalidixic acid
Nucleotide sequence
Original
Quinolones
Species
Whole genome sequencing
Campylobacter hyointestinalis
cattle
cgMLST
antimicrobial resistance
whole-genome sequencing
Campylobacter jejuni
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Summary:Aims Cattle are the second most important cause of human campylobacteriosis, after poultry, but there are knowledge gaps regarding Campylobacter in cattle. This study examined the occurrence of Campylobacter, the species present, sequence types and antibiotic resistance in Swedish cattle. Methods and Results Faeces samples collected from 154 calves on seven Swedish farms, and 69 follow‐up samples from a second collection occasion, were analysed. Campylobacter were isolated from 77% of calves at the first sampling, with Campylobacter jejuni as the most frequently isolated species. Animals kept on deep straw bedding were less likely to be colonized with Campylobacter. Whole‐genome sequencing of 90 C. jejuni samples resulted in 11 sequence types, among which ST‐19 and ST‐21 were most frequent. Antimicrobial resistance analyses showed that 46% of 142 isolates analysed were resistant to quinolones, while all isolates belonging to ST‐19, ST‐22 and ST‐441 were resistant to ciprofloxacin and nalidixic acid. Conclusions Campylobacter jejuni was the species most frequently isolated in calves and a strong association was found between sequence type and antimicrobial resistance pattern. Significance and Impact of the Study The high proportion of calves with quinolone‐resistant Campylobacter jejuni should be considered in a One Health perspective.
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ISSN:1364-5072
1365-2672
1365-2672
DOI:10.1111/jam.14914