Search Results - "Tamir, Rami"

Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats by Lehto, Sonya G, Tamir, Rami, Deng, Hong, Klionsky, Lana, Kuang, Rongzhen, Le, April, Lee, Doo, Louis, Jean-Claude, Magal, Ella, Manning, Barton H, Rubino, John, Surapaneni, Sekhar, Tamayo, Nuria, Wang, Tingrong, Wang, Judy, Wang, Jue, Wang, Weiya, Youngblood, Brad, Zhang, Maosheng, Zhu, Dawn, Norman, Mark H, Gavva, Narender R

“…Antagonists of the vanilloid receptor TRPV1 (transient receptor potential vanilloid type 1) have been reported to produce antihyperalgesic effects in animal…”
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AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties by Gavva, Narender R, Tamir, Rami, Qu, Yusheng, Klionsky, Lana, Zhang, T J, Immke, David, Wang, Judy, Zhu, Dawn, Vanderah, Todd W, Porreca, Frank, Doherty, Elizabeth M, Norman, Mark H, Wild, Kenneth D, Bannon, Anthony W, Louis, Jean-Claude, Treanor, James J S

“…The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel expressed by peripheral sensory neurons. TRPV1 antagonists produce…”
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Species-Specific Pharmacology of Trichloro(Sulfanyl)ethyl Benzamides as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists by Klionsky, Lana, Tamir, Rami, Gao, BaoXi, Wang, Weiya, Immke, David C, Nishimura, Nobuko, Gavva, Narender R

“…Agonists of TRPA1 such as mustard oil and its key component AITC cause pain and neurogenic inflammation in humans and pain behavior in rodents. TRPA1 is…”
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Molecular Determinants of Vanilloid Sensitivity in TRPV1 by Gavva, Narender R, Klionsky, Lana, Qu, Yusheng, Shi, Licheng, Tamir, Rami, Edenson, Steve, Zhang, T J, Viswanadhan, Vellarkad N, Toth, Attila, Pearce, Larry V, Vanderah, Todd W, Porreca, Frank, Blumberg, Peter M, Lile, Jack, Sun, Yax, Wild, Ken, Louis, Jean-Claude, Treanor, James J S

“…Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent…”
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Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade by Gavva, Narender R, Bannon, Anthony W, Hovland, Jr, David N, Lehto, Sonya G, Klionsky, Lana, Surapaneni, Sekhar, Immke, David C, Henley, Charles, Arik, Leyla, Bak, Annette, Davis, James, Ernst, Nadia, Hever, Gal, Kuang, Rongzhen, Shi, Licheng, Tamir, Rami, Wang, Jue, Wang, Weiya, Zajic, Gary, Zhu, Dawn, Norman, Mark H, Louis, Jean-Claude, Magal, Ella, Treanor, James J S

“…Capsaicin, the active ingredient in some pain-relieving creams, is an agonist of a nonselective cation channel known as the transient receptor potential…”
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Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1 by Gavva, Narender R, Tamir, Rami, Klionsky, Lana, Norman, Mark H, Louis, Jean-Claude, Wild, Kenneth D, Treanor, James J S

“…Vanilloid receptor 1 (TRPV1) is activated by chemical ligands (e.g., capsaicin and protons) and heat. In this study, we show that…”
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A polyclonal antibody to the prepore loop of transient receptor potential vanilloid type 1 blocks channel activation by Klionsky, Lana, Tamir, Rami, Holzinger, Bob, Bi, Xiaojuan, Talvenheimo, Jane, Kim, Helen, Martin, Frank, Louis, Jean-Claude, Treanor, James J S, Gavva, Narender R

“…Transient receptor potential vanilloid type 1 (TRPV1) can be activated by multiple chemical and physical stimuli such as capsaicin, anandamide, protons, and…”
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Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles by Ognyanov, Vassil I, Balan, Chenera, Bannon, Anthony W, Bo, Yunxin, Dominguez, Celia, Fotsch, Christopher, Gore, Vijay K, Klionsky, Lana, Ma, Vu V, Qian, Yi-Xin, Tamir, Rami, Wang, Xianghong, Xi, Ning, Xu, Shimin, Zhu, Dawn, Gavva, Narender R, Treanor, James J. S, Norman, Mark H

“…The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful…”
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KTP/532 YAG laser treatment for allergic rhinitis by Yaniv, Eitan, Hadar, Tuvia, Shvero, Jacob, Tamir, Rami, Nageris, Ben

“…The purpose of this study was to investigate the efficacy of the KTP/532 YAG laser to reduce nasal congestion and discharge in patients with allergic rhinitis…”
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The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation by Gavva, Narender R, Bannon, Anthony W, Surapaneni, Sekhar, Hovland, David N., Jr, Lehto, Sonya G, Gore, Anu, Juan, Todd, Deng, Hong, Han, Bora, Klionsky, Lana, Kuang, Rongzhen, Le, April, Tamir, Rami, Wang, Jue, Youngblood, Brad, Zhu, Dawn, Norman, Mark H, Magal, Ella, Treanor, James J. S, Louis, Jean-Claude

“…The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such…”
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Generation of suppressor cells in atopic patients during immunotherapy that modulate IgE synthesis by Tamir, R, Castracane, J M, Rocklin, R E

“…We prospectively studied the effect of ragweed immunotherapy on the generation of suppressor T cells that modulate total and antiragweed IgE production in five…”
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Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists by Tamayo, Nuria, Liao, Hongyu, Stec, Markian M, Wang, Xianghong, Chakrabarti, Partha, Retz, Dan, Doherty, Elizabeth M, Surapaneni, Sekhar, Tamir, Rami, Bannon, Anthony W, Gavva, Narender R, Norman, Mark H

“…Transient receptor potential vanilloid 1 (TRPV1) channel antagonists may have clinical utility for the treatment of chronic nociceptive and neuropathic pain…”
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Novel Vanilloid Receptor-1 Antagonists:  2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate by Doherty, Elizabeth M, Fotsch, Christopher, Bannon, Anthony W, Bo, Yunxin, Chen, Ning, Dominguez, Celia, Falsey, James, Gavva, Narender R, Katon, Jodie, Nixey, Thomas, Ognyanov, Vassil I, Pettus, Liping, Rzasa, Robert M, Stec, Markian, Surapaneni, Sekhar, Tamir, Rami, Zhu, Jiawang, Treanor, James J. S, Norman, Mark H

“…A series of novel 4-oxopyrimidine TRPV1 antagonists was evaluated in assays measuring the blockade of capsaicin or acid-induced influx of calcium into CHO…”
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GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF by Jing, Shuqian, Wen, Duanzhi, Yu, Yanbin, Holst, Paige L, Luo, Yi, Fang, Mei, Tamir, Rami, Antonio, Laarni, Hu, Zheng, Cupples, Rod, Louis, Jean-Claude, Hu, Sylvia, Altrock, Bruce W, Fox, Gary M

“…We report the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line–derived…”
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Abstract 2058: Translational regulation of SPARC by the microRNAs mir29a, b, and c by Trieu, Vuong, Hwang, Larn, Lin, Xiaoqin, Tamir, Rami, Motamed, Kouros, Desai, Neil

“…Abstract Background: SPARC (Secreted Protein Acidic and Rich in Cysteine) is overexpressed in most cancers, including breast, prostate, lung, brain,…”
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Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N-Aryl Cinnamides by Doherty, Elizabeth M, Fotsch, Christopher, Bo, Yunxin, Chakrabarti, Partha P, Chen, Ning, Gavva, Narender, Han, Nianhe, Kelly, Michael G, Kincaid, John, Klionsky, Lana, Liu, Qingyian, Ognyanov, Vassil I, Tamir, Rami, Wang, Xianghong, Zhu, Jiawang, Norman, Mark H, Treanor, James J. S

“…The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role in regulating the…”
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Novel Vanilloid Receptor-1 Antagonists:  3. The Identification of a Second-Generation Clinical Candidate with Improved Physicochemical and Pharmacokinetic Properties by Wang, Hui-Ling, Katon, Jodie, Balan, Chenera, Bannon, Anthony W, Bernard, Charles, Doherty, Elizabeth M, Dominguez, Celia, Gavva, Narender R, Gore, Vijay, Ma, Vu, Nishimura, Nobuko, Surapaneni, Sekhar, Tang, Phi, Tamir, Rami, Thiel, Oliver, Treanor, James J. S, Norman, Mark H

“…Based on the previously reported clinical candidate, AMG 517 (compound 1), a series of related piperazinylpyrimidine analogues were synthesized and evaluated…”
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Novel Vanilloid Receptor-1 Antagonists:  1. Conformationally Restricted Analogues of trans-Cinnamides by Norman, Mark H, Zhu, Jiawang, Fotsch, Christopher, Bo, Yunxin, Chen, Ning, Chakrabarti, Partha, Doherty, Elizabeth M, Gavva, Narender R, Nishimura, Nobuko, Nixey, Thomas, Ognyanov, Vassil I, Rzasa, Robert M, Stec, Markian, Surapaneni, Sekhar, Tamir, Rami, Viswanadhan, Vellarkad N, Treanor, James J. S

“…The vanilloid receptor-1 (VR1 or TRPV1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role as an integrator of…”
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Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists by Gore, Vijay K., Ma, Vu V., Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.

“…A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs…”
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Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists by Stec, Markian M., Bo, Yunxin, Chakrabarti, Partha P., Liao, Lillian, Ncube, Mqhele, Tamayo, Nuria, Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.

“…Analogs with various substituents at the R region of 3 were prepared to improve the solubility while maintaining the potent TRPV1 activity of clinical…”
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