Effects of red blood cells on the coagulation of blood in normal and preeclamptic pregnancies

Effects of red blood cells on the coagulation of blood in normal and preeclamptic pregnancies

Objective: The objective of this study was to determine the cellular effects of whole blood, especially of red blood cells, on the hypercoagulability of blood from patients with preeclampsia. Study Design: The time elapsed between mixing and the onset of coagulation was measured by means of a highly...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology Vol. 180; no. 2; pp. 402 - 405
Main Authors: Kaibara, Manabu, Mitsuhashi, Yoichi, Watanabe, Takaya, Tamiaki, Fumiko, Nishihira, Masayuki, Sadatsuki, Miyuki, Aisaka, Kohzo
Format: Journal Article
Language:English
Published: Philadelphia, PA Mosby, Inc 01-02-1999
Elsevier
Subjects:
Adult
Biological and medical sciences
Blood Coagulation
Blood Platelets - physiology
Diseases of mother, fetus and pregnancy
Erythrocytes - physiology
Female
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Plasma - physiology
Pre-Eclampsia - blood
preeclampsia
Pregnancy
pregnancy-induced hypertension
Pregnancy. Fetus. Placenta
red blood cells
Time Factors
Asia
Japan
red blood cells
Blood coagulation
pregnancy-induced hypertension
preeclampsia
Human
Hypercoagulability
Pregnancy disorders
Pathophysiology
Pathogenesis
Clotting time
Red blood cell
Hemopathy
Pregnancy toxemia
Biological activity
Whole blood
Platelet
Preeclampsia
Adult
Female
Coagulopathy
Comparative study
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Summary:Objective: The objective of this study was to determine the cellular effects of whole blood, especially of red blood cells, on the hypercoagulability of blood from patients with preeclampsia. Study Design: The time elapsed between mixing and the onset of coagulation was measured by means of a highly sensitive rheometer for whole blood, platelet-rich plasma (in which red blood cells had been removed from whole blood), and platelet-free plasma from 3 groups of subjects: 25 nonpregnant women, 25 women with normal pregnancies, and 10 patients with preeclampsia. Results: Time to coagulation for whole blood from patients with preeclampsia was significantly shorter than that for whole blood from women with normal pregnancies. However, there was no significant difference in time to coagulation for platelet-rich plasma between women with preeclampsia and those with normal pregnancies. Conclusion: Hypercoagulability of blood in preeclampsia appears to be strongly related to red blood cell alterations.(Am J Obstet Gynecol 1999;180:402-5.)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(99)70222-X