Search Results - "Tame, J"

Crystal structures of Scone: pseudosymmetric folding of a symmetric designer protein by Mylemans, B., Killian, T., Vandebroek, L., Van Meervelt, L., Tame, J. R. H., Parac-Vogt, T. N., Voet, A. R. D.

“…Recent years have seen an increase in the development of computational proteins, including symmetric ones. A ninefold‐symmetric β‐propeller protein named Cake…”
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Higuchi’s fractal dimension, but not frontal or posterior alpha asymmetry, predicts PID-5 anxiousness more than depressivity by Kawe, Tame N. J., Shadli, Shabah M., McNaughton, Neil

“…Depression is a major cause of health disability. EEG measures may provide one or more economical biomarkers for the diagnosis of depression. Here we compared…”
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Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations by Foster, Robert W., Tame, Christopher J., Hailes, Helen C., Sheppard, Tom D.

“…(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide‐tethered diynes…”
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71 Using induced sputum for microbiological surveillance in young healthy non-productive children with cystic fibrosis precludes the need for bronchoscopy in 70% of cases: results from the CF-SpIT study by Roncetti, K, Tame, J, Wootton, M, Howe, R, Forton, I

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183 Mycobacterium abscessus : stand alone hospital admission for agressive physiotherapy and nutritional review can extend periods between toxic IV antibiotic treatments by Tame, J, Turnbull, A, Forton, J

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69 The Cystic Fibrosis Sputum Induction Trial ( CF-SpIT ). Induced sputum in young healthy non-productive children with cystic fibrosis by Tame, J, Ronchetti, K, Paisey, C, Doull, I, Mahenthiralingham, E, Howe, R, Forton, J.T

“…Objective Young children with CF are often non-productive of sputum even during a chest exacerbation. Effective bacterial surveillance is challenging, but…”
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218 Cystic fibrosis sputum induction trial (CF-SpIT). Tolerability data for induced sputum sampling in children with cystic fibrosis by Tame, J, Ronchetti, K, Doull, I, Forton, J.T

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The detection of Tomato spotted wilt virus (TSWV) in individual thrips using real time fluorescent RT-PCR (TaqMan) by Boonham, N., Smith, P., Walsh, K., Tame, J., Morris, J., Spence, N., Bennison, J., Barker, I.

“…Tomato spotted wilt virus (TSWV) is an important virus, economically in the UK, causing damaging disease in ornamental and vegetable crops. The virus is…”
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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs by Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.

“…Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing…”
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Structural Insights into PROTAC-Mediated Degradation of Bcl-xL by Chung, Chun-wa, Dai, Han, Fernandez, Esther, Tinworth, Christopher P, Churcher, Ian, Cryan, Jenni, Denyer, Jane, Harling, John D, Konopacka, Agnieszka, Queisser, Markus A, Tame, Christopher J, Watt, Gillian, Jiang, Fan, Qian, Dongming, Benowitz, Andrew B

“…The Bcl-2 family of proteins, such as Bcl-xL and Bcl-2, play key roles in cancer cell survival. Structural studies of Bcl-xL formed the foundation for the…”
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Crystallographic and Calorimetric Analysis of Peptide Binding to OppA Protein by Sleigh, S.H., Seavers, P.R., Wilkinson, A.J., Ladbury, J.E., Tame, J.R.H.

“…Isothermal titration calorimetry has been used to study the binding of 20 different peptides to the peptide binding protein OppA, and the crystal structures of…”
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The Structural Basis of Sequence-Independent Peptide Binding by OppA Protein by Jeremy R. H. Tame, Murshudov, Garib N., Dodson, Eleanor J., Neil, Teresa K., Dodson, Guy G., Higgins, Christopher F., Wilkinson, Anthony J.

“…Specific protein-ligand interactions are critical for cellular function, and most proteins select their partners with sharp discrimination. However, the…”
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Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless asymmetric dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4 by Richardson, Melodie S. W, Tame, Christopher J, Poole, Darren L, Donohoe, Timothy J

“…Our synthesis of the CDE ring fragment of pectenotoxin-4 utilised two key steps to make the complex bicyclic ketal unit: (i) a rhodium-catalysed vinyl group…”
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Gold catalysed synthesis of 3-alkoxyfurans at room temperature by Pennell, Matthew N, Foster, Robert W, Turner, Peter G, Hailes, Helen C, Tame, Christopher J, Sheppard, Tom D

“…Synthetically important 3-alkoxyfurans can be prepared efficiently via treatment of acetal-containing propargylic alcohols (obtained from the addition of…”
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Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses by Foster, Robert W., Tame, Christopher J., Bučar, Dejan-Krešimir, Hailes, Helen C., Sheppard, Tom D.

“…L‐Arabinose is an abundant resource available as a waste product of the sugar beet industry. Through use of a hydrazone‐based strategy, L‐arabinose was…”
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Irreversible endo-Selective Diels-Alder Reactions of Substituted Alkoxyfurans: A General Synthesis of endo-Cantharimides by Foster, Robert W., Benhamou, Laure, Porter, Michael J., Bučar, Dejan-Krešimir, Hailes, Helen C., Tame, Christopher J., Sheppard, Tom D.

“…The [4+2] cycloaddition of 3‐alkoxyfurans with N‐substituted maleimides provides the first general route for preparing endo‐cantharimides. Unlike the…”
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Relating structure to thermodynamics: The crystal structures and binding affinity of eight OppA-peptide complexes by DAVIES, THOMAS G., HUBBARD, RODERICK E., TAME, JEREMY R.H.

“…The oligopeptide-binding protein OppA provides a useful model system for studying the physical chemistry underlying noncovalent interactions since it binds a…”
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Mutant hemoglobins (alpha 119-Ala and beta 55-Ser): functions related to high-altitude respiration in geese by Weber, R E, Jessen, T H, Malte, H, Tame, J

“…The unusually high blood-O2 affinity in the bar-headed and Andean geese is a necessary adaptation for migration across high mountain ranges. The amino acid…”
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Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease by Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie

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Investigation of the radiological relationship between iliac crests, conus medullaris and vertebral level in children by Tame, Simon J., Burstal, Richard

“…Summary Background: The inability of anaesthetists to accurately identify vertebral spaces has been documented. The aim of our magnetic resonance imaging (MRI)…”
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