Tc-99m HMPAO Scintigraphy in Amiodarone-Induced Acute Lung Toxicity: Comparison With Tc-99m DTPA Inhalation Scintigraphy

PURPOSE:This case demonstrates the use of Tc-99m HMPAO scintigraphy in amiodarone (AD)-induced lung toxicity. The aim of this presentation is also to discuss different scintigraphic modalities in the diagnosis and follow up in AD-induced lung toxicity. MATERIALS AND METHODS:A 77-year-old man, with a...

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Bibliographic Details
Published in:	Clinical nuclear medicine Vol. 31; no. 11; pp. 697 - 700
Main Authors:	Kaya, Gamze Kapa, Ozdogan, O, Guneri, S, Tamc, B, Durak, H
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins, Inc 01-11-2006
Subjects:	Administration, Inhalation Aged Amiodarone - adverse effects Anti-Arrhythmia Agents - adverse effects Humans Image Enhancement - methods Lung Diseases - chemically induced Lung Diseases - diagnostic imaging Male Radiography Radiopharmaceuticals - administration & dosage Technetium Tc 99m Exametazime Technetium Tc 99m Pentetate - administration & dosage
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Summary:	PURPOSE:This case demonstrates the use of Tc-99m HMPAO scintigraphy in amiodarone (AD)-induced lung toxicity. The aim of this presentation is also to discuss different scintigraphic modalities in the diagnosis and follow up in AD-induced lung toxicity. MATERIALS AND METHODS:A 77-year-old man, with a suspicious AD-induced acute lung toxicity, underwent Tc-99m DTPA aerosol inhalation scintigraphy and Tc-99m HMPAO scintigraphy. RESULTS:Rapid alveolar clearance of Tc-99m DTPA was found during AD therapy and increased lung uptake of Tc-99m HMPAO was also demonstrated. These findings supported the diagnosis AD lung toxicity. After cessation of therapy, Tc-99m DTPA alveolar clearance was decreased. Although there was some decrease in L/H and L/B ratios of Tc-99m HMPAO after 3 weeks of stopping therapy, Tc-99m HMPAO uptake in the lungs was still continued. This finding may be the result of ongoing pulmonary inflammation as a result of the long half-life of AD. CONCLUSION:Compared with Tc-99m DTPA aerosol inhalation scintigraphy, Tc-99m HMPAO scintigraphy may have a role in the diagnosis of AD lung toxicity. Nevertheless, there is a need for longitudinal studies investigating patients under AD therapy using follow-up Tc-9m HMPAO scintigraphy.
ISSN:	0363-9762 1536-0229
DOI:	10.1097/01.rlu.0000242697.49893.e7