Search Results - "Tamburino, Alex M"

Germline gain-of-function mutations in SOS1 cause Noonan syndrome by Neel, Benjamin G, Roberts, Amy E, Araki, Toshiyuki, Swanson, Kenneth D, Montgomery, Kate T, Schiripo, Taryn A, Joshi, Victoria A, Li, Li, Yassin, Yosuf, Tamburino, Alex M, Kucherlapati, Raju S

“…Noonan syndrome, the most common single-gene cause of congenital heart disease, is characterized by short stature, characteristic facies, learning problems and…”
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Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells by Staupe, Ryan P., Lodge, Kenneth E., Thambi, Nithya, Toole, David, Tamburino, Alex M., Chang, Dan, Howell, Bonnie J., Hazuda, Daria J., Vora, Kalpit A., Sullivan, Nicole L.

“…In response to infection or immunization, antibodies are produced that provide protection against re-exposure with the same pathogen. These antibodies can…”
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Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities by Podtelezhnikov, Alexei A, Monroe, James J, Aslamkhan, Amy G, Pearson, Kara, Qin, Chunhua, Tamburino, Alex M, Loboda, Andrey P, Glaab, Warren E, Sistare, Frank D, Tanis, Keith Q

“…Abstract The robust transcriptional plasticity of liver mediated through xenobiotic receptors underlies its ability to respond rapidly and effectively to…”
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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury by Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D

“…Abstract Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted…”
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Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity by Li, Yutai, Evers, Raymond, Hafey, Michael J, Cheon, Kyeongmi, Duong, Hong, Lynch, Donna, LaFranco-Scheuch, Lisa, Pacchione, Stephen, Tamburino, Alex M, Tanis, Keith Q, Geddes, Kristin, Holder, Daniel, Zhang, Nanyan Rena, Kang, Wen, Gonzalez, Raymond J, Galijatovic-Idrizbegovic, Alema, Pearson, Kara M, Lebron, Jose A, Glaab, Warren E, Sistare, Frank D

“…Abstract Inhibition of the bile salt export pump (BSEP) may be associated with clinical drug-induced liver injury, but is poorly predicted by preclinical…”
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Transcription factor binding to Caenorhabditis elegans first introns reveals lack of redundancy with gene promoters by Fuxman Bass, Juan I, Tamburino, Alex M, Mori, Akihiro, Beittel, Nathan, Weirauch, Matthew T, Reece-Hoyes, John S, Walhout, Albertha J M

“…Gene expression is controlled through the binding of transcription factors (TFs) to regulatory genomic regions. First introns are longer than other introns in…”
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A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels by Tamburino, Alex M, Ryder, Sean P, Walhout, Albertha J M

“…Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level…”
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PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions by Tamburino, Alex M., Kaymak, Ebru, Shrestha, Shaleen, Holdorf, Amy D., Ryder, Sean P., Walhout, Albertha J. M.

“…Interactions between RNA binding proteins (RBPs) and mRNAs are critical to post-transcriptional gene regulation. Eukaryotic genomes encode thousands of mRNAs…”
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Abstract B009: Characterization and CRISPR perturbation of cancer-associated fibroblast heterogeneity in vitro models by Saputra, Elysia, Vellarikkal, Shamsudheen Karuthedath, Li, Lixia, Sun, Hong, Natarajan, Suchitra, Piccioni, Federica, Tamburino, Alex M., Yu, Xin, Olow, Aleksandra K.

“…Abstract Cancer-associated fibroblasts (CAFs) are attractive therapeutic targets for cancer due to their abundance in the tumor microenvironment (TME) and…”
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