Search Results - "Tambe, Akshay"

Barcode identification for single cell genomics by Tambe, Akshay, Pachter, Lior

“…Single-cell sequencing experiments use short DNA barcode 'tags' to identify reads that originate from the same cell. In order to recover single-cell…”
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RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a by Tambe, Akshay, East-Seletsky, Alexandra, Knott, Gavin J., Doudna, Jennifer A., O’Connell, Mitchell R.

“…CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA…”
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Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis by Wilson, Ross C., Tambe, Akshay, Kidwell, Mary Anne, Noland, Cameron L., Schneider, Catherine P., Doudna, Jennifer A.

“…RNA-mediated gene silencing in human cells requires the accurate generation of ∼22 nt microRNAs (miRNAs) from double-stranded RNA substrates by the…”
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RNA-guided assembly of Rev-RRE nuclear export complexes by Bai, Yun, Tambe, Akshay, Zhou, Kaihong, Doudna, Jennifer A

“…HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although a unique RNA structure has been proposed for the…”
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Developing Experimental and Computational Tools for Sequence-Census Assays by Tambe, Akshay

“…Genomic data has revolutionized biology. The related development of high-throughput DNA sequencers has had a major impact on this, as the DNA sequencing…”
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Identifying RNA contacts from SHAPE-MaP by partial correlation analysis by Tambe, Akshay, Doudna, Jennifer, Pachter, Lior

“…In a recent paper Siegfried et al. published a new sequence-based structural RNA assay that utilizes mutational profiling to detect base pairing (MaP). Output…”
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