Search Results - "Tamar Pirtskhalava"

Cellular senescence mediates fibrotic pulmonary disease by Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence…”
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age by Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.

“…Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of…”
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Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors by Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.

“…Summary Clearing senescent cells extends healthspan in mice. Using a hypothesis‐driven bioinformatics‐based approach, we recently identified pro‐survival…”
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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice by Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.

“…Summary While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long‐term senolytic treatment…”
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice by Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana

“…Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a…”
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Targeting senescent cells enhances adipogenesis and metabolic function in old age by Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L

“…Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy…”
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Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes by TCHKONIA, Tamara, GIORGADZE, Nino, KIRKLAND, James L, PIRTSKHALAVA, Tamar, THOMOU, Thomas, DEPONTE, Matthew, KOO, Ada, ARMOUR FORSE, R, CHINNAPPAN, Dharmaraj, MARTIN-RUIZ, Carmen, VON ZGLINICKI, Thomas

“…Fat Depot–Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes Tamara Tchkonia 1 , Nino Giorgadze 1 , Tamar Pirtskhalava 1…”
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Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns by Tchkonia, Tamara, Lenburg, Marc, Thomou, Thomas, Giorgadze, Nino, Frampton, Garrett, Pirtskhalava, Tamar, Cartwright, Andrew, Cartwright, Mark, Flanagan, John, Karagiannides, Iordanes, Gerry, Norman, Forse, R Armour, Tchoukalova, Yourka, Jensen, Michael D, Pothoulakis, Charalabos, Kirkland, James L

“…Anatomically separate fat depots differ in size, function, and contribution to pathological states, such as the metabolic syndrome. We isolated preadipocytes…”
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Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice by Stojakovic, Andrea, Trushin, Sergey, Sheu, Anthony, Khalili, Layla, Chang, Su-Youne, Li, Xing, Christensen, Trace, Salisbury, Jeffrey L., Geroux, Rachel E., Gateno, Benjamin, Flannery, Padraig J., Dehankar, Mrunal, Funk, Cory C., Wilkins, Jordan, Stepanova, Anna, O’Hagan, Tara, Galkin, Alexander, Nesbitt, Jarred, Zhu, Xiujuan, Tripathi, Utkarsh, Macura, Slobodan, Tchkonia, Tamar, Pirtskhalava, Tamar, Kirkland, James L., Kudgus, Rachel A., Schoon, Renee A., Reid, Joel M., Yamazaki, Yu, Kanekiyo, Takahisa, Zhang, Song, Nemutlu, Emirhan, Dzeja, Petras, Jaspersen, Adam, Kwon, Ye In Christopher, Lee, Michael K., Trushina, Eugenia

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Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity by Guo, Wen, Pirtskhalava, Tamar, Tchkonia, Tamara, Xie, Weisheng, Thomou, Thomas, Han, Jianrong, Wang, Tong, Wong, Siu, Cartwright, Andrew, Hegardt, Fausto G, Corkey, Barbara E, Kirkland, James L

“…Aging is associated with metabolic syndrome, tissue damage by cytotoxic lipids, and altered fatty acid handling. Fat tissue dysfunction may contribute to these…”
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Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes by Tchkonia, Tamara, Giorgadze, Nino, Pirtskhalava, Tamar, Tchoukalova, Yourka, Karagiannides, Iordanes, Forse, R Armour, DePonte, Matthew, Stevenson, Michael, Guo, Wen, Han, Jianrong, Waloga, Gerri, Lash, Timothy L, Jensen, Michael D, Kirkland, James L

“…Fat distribution varies among individuals with similar body fat content. Innate differences in adipose cell characteristics may contribute because lipid…”
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Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging by Karagiannides, Iordanes, Thomou, Thomas, Tchkonia, Tamara, Pirtskhalava, Tamar, Kypreos, Kyriakos E., Cartwright, Andrew, Dalagiorgou, Georgia, Lash, Timothy L., Farmer, Stephen R., Timchenko, Nikolai A., Kirkland, James L.

“…Preadipocyte differentiation capacity declines between middle and old age. Expression of the adipogenic transcription factors, CCAAT/enhancer-binding protein…”
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Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes by Han, Jianrong, Farmer, Stephen R, Kirkland, James L, Corkey, Barbara E, Yoon, Richard, Pirtskhalava, Tamar, Ido, Yasuo, Guo, Wen

“…Preadipocytes exposed to octanoate accumulate less lipid than cells exposed to long-chain fatty acids. This effect of octanoate involves significant…”
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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 by Zhu, Yi, Doornebal, Ewald J., Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D., Tchkonia, Tamara, Kirkland, James L.

“…Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of…”
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New agents that target senescent cells: the flavone, fisetin, and the BCL-X L inhibitors, A1331852 and A1155463 by Zhu, Yi, Doornebal, Ewald J, Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J, Robbins, Paul D, Tchkonia, Tamara, Kirkland, James L

“…Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of…”
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Targeting cellular senescence prevents age-related bone loss in mice by Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, Khosla, Sundeep

“…Genetic or pharmacological depletion of senescent cells or inhibition of their function reduces bone loss in aged mice. Aging is associated with increased…”
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Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice by Xu, Ming, Bradley, Elizabeth W, Weivoda, Megan M, Hwang, Soyun M, Pirtskhalava, Tamar, Decklever, Teresa, Curran, Geoffry L, Ogrodnik, Mikolaj, Jurk, Diana, Johnson, Kurt O, Lowe, Val, Tchkonia, Tamar, Westendorf, Jennifer J, Kirkland, James L

“…Osteoarthritis (OA) is the leading form of arthritis in the elderly, causing pain, disability, and immobility. OA has been associated with accumulation of…”
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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis by Ogrodnik, Mikolaj, Zhu, Yi, Langhi, Larissa G.P., Tchkonia, Tamar, Krüger, Patrick, Fielder, Edward, Victorelli, Stella, Ruswhandi, Rifqha A., Giorgadze, Nino, Pirtskhalava, Tamar, Podgorni, Oleg, Enikolopov, Grigori, Johnson, Kurt O., Xu, Ming, Inman, Christine, Palmer, Allyson K., Schafer, Marissa, Weigl, Moritz, Ikeno, Yuji, Burns, Terry C., Passos, João F., von Zglinicki, Thomas, Kirkland, James L., Jurk, Diana

“…Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory phenotype, which contributes to aging and age-related diseases. Obesity…”
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Senolytics improve physical function and increase lifespan in old age by Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.

“…Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction,…”
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Targeting senescent cells alleviates obesity‐induced metabolic dysfunction by Palmer, Allyson K., Xu, Ming, Zhu, Yi, Pirtskhalava, Tamar, Weivoda, Megan M., Hachfeld, Christine M., Prata, Larissa G., Dijk, Theo H., Verkade, Esther, Casaclang‐Verzosa, Grace, Johnson, Kurt O., Cubro, Hajrunisa, Doornebal, Ewald J., Ogrodnik, Mikolaj, Jurk, Diana, Jensen, Michael D., Chini, Eduardo N., Miller, Jordan D., Matveyenko, Aleksey, Stout, Michael B., Schafer, Marissa J., White, Thomas A., Hickson, LaTonya J., Demaria, Marco, Garovic, Vesna, Grande, Joseph, Arriaga, Edgar A., Kuipers, Folkert, Zglinicki, Thomas, LeBrasseur, Nathan K., Campisi, Judith, Tchkonia, Tamar, Kirkland, James L.

“…Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin resistance and diabetes, but mechanisms underlying this relationship…”
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