Search Results - "Tamamizu, Shiori"
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Acrolein Modification Impairs Key Functional Features of Rat Apolipoprotein E: Identification of Modified Sites by Mass Spectrometry
Published in Biochemistry (Easton) (21-01-2014)“…Apolipoprotein E (apoE), an antiatherogenic apolipoprotein, plays a significant role in the metabolism of lipoproteins. It lowers plasma lipid levels by acting…”
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2
Slow-Channel Transgenic Mice: A Model of Postsynaptic Organellar Degeneration at the Neuromuscular Junction
Published in The Journal of neuroscience (01-06-1997)“…The slow-channel congenital myasthenic syndrome (SCCMS) is a dominantly inherited disorder of neuromuscular transmission characterized by delayed closure of…”
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3
Effects of Antibody Binding on Structural Transitions of the Nicotinic Acetylcholine Receptor
Published in Biochemistry (Easton) (10-09-1996)“…Patch-clamping and photoaffinity-labeling techniques were used to study the effects of binding of monoclonal antibodies (mAbs) on the function of Torpedo…”
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4
Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide
Published in Biochemical journal (01-08-2009)“…AD (Alzheimer's disease) is linked to Abeta (amyloid beta-peptide) misfolding. Studies demonstrate that the level of soluble Abeta oligomeric forms correlates…”
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5
Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity
Published in The Journal of biological chemistry (01-10-2004)“…Hypoxia-inducible factor (HIF)-1α is a transcription factor that controls expression of genes responsive to low oxygen tension, including vascular endothelial…”
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6
Changes in trypsin-binding properties and conformation of rabbit alpha-2-macroglobulin on reaction with methylamine
Published in Journal of biochemistry (Tokyo) (01-06-1989)“…Reactions of rabbit alpha-2-macroglobulin with methylamine and trypsin were studied and the results were compared with those obtained for previously described…”
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7
Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity
Published in The Journal of biological chemistry (01-10-2004)Get full text
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8
Functional Effects of Periodic Tryptophan Substitutions in the α M4 Transmembrane Domain of the Torpedo californica Nicotinic Acetylcholine Receptor
Published in Biochemistry (Easton) (25-04-2000)“…Previous amino acid substitutions at the M4 domain of the Torpedo californica and mouse acetylcholine receptor suggested that the location of the substitution…”
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9
A beta-subunit mutation in the acetylcholine receptor channel gate causes severe slow-channel syndrome
Published in Annals of neurology (01-06-1996)“…Point mutations in the genes encoding the acetylcholine receptor (AChR) subunits have been recognized in some patients with slow-channel congenital myasthenic…”
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10
Tryptophan Substitutions at the Lipid-Exposed Transmembrane Segment M4 of Torpedo californica Acetylcholine Receptor Govern Channel Gating
Published in Biochemistry (Easton) (12-11-1996)“…Our previous amino acid substitutions at the postulated lipid-exposed transmembrane segment M4 of the Torpedo californica acetylcholine receptor (AChR) focused…”
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11
Calcium-Triggered Membrane Interaction of the α-Synuclein Acidic Tail
Published in Biochemistry (Easton) (12-09-2006)“…α-Synuclein (α-syn) is a 140-residue protein that aggregates in intraneuronal inclusions called Lewy bodies in Parkinson's disease (PD). It is composed of an…”
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12
Modification by Acrolein, a Component of Tobacco Smoke and Age-Related Oxidative Stress, Mediates Functional Impairment of Human Apolipoprotein E
Published in Biochemistry (Easton) (17-07-2007)“…Oxidative damage to proteins such as apolipoprotein B-100 increases the atherogenicity of low-density lipoproteins (LDL). However, little is known about the…”
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13
Interaction with Amyloid β Peptide Compromises the Lipid Binding Function of Apolipoprotein E
Published in Biochemistry (Easton) (06-05-2008)“…Apolipoprotein (apo) E is an exchangeable apolipoprotein that plays an integral role in cholesterol transport in the plasma and the brain. It is also…”
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14
Inhibitory effects of Saiko-seikan-to and Saiko-keishi-to on the growth of hepatocarcinoma cells
Published in Japanese Journal of Pharmacology (2000)“…The effects of the herbal (Kampo) medicines on a human hepatocarcinoma cell line (HCC-M) were investigated by measurement of the survival rate of the cells…”
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15
Second hand smoke exposure mediates oxidative modification of plasma apolipoprotein E
Published in The FASEB journal (01-04-2010)“…The objective of our study was to assess if second hand smoke exposure predisposes subjects towards developing heart disease. We monitored the effect of…”
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16
Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
Published in The Journal of biological chemistry (01-10-2004)“…Hypoxia-inducible factor (HIF)-1alpha is a transcription factor that controls expression of genes responsive to low oxygen tension, including vascular…”
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17
Interaction with Amyloid b Peptide Compromises the Lipid Binding Function of Apolipoprotein E
Published in Biochemistry (Easton) (12-04-2008)“…Apolipoprotein (apo) E is an exchangeable apolipoprotein that plays an integral role in cholesterol transport in the plasma and the brain. It is also…”
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18
Histone deacetylase7 regulates subcellular localization of HIF‐1α upon transition from hypoxia to normoxia (re‐oxygenation)
Published in The FASEB journal (01-03-2006)“…Hypoxia‐inducible factor‐1α (HIF‐1α) is a transcription factor, which plays an important role in physiological response to hypoxia by expression of various…”
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19
Mutations in the M1 region of the nicotinic acetylcholine receptor alter the sensitivity to inhibition by quinacrine
Published in Cellular and molecular neurobiology (01-08-1995)“…1. Site directed mutagenesis was used to alter the structure of Torpedo californica nicotinic acetylcholine receptor (nAChR) and to identify amino acid…”
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20
Functional consequence of apolipoprotein E/amyloid peptide interaction in Alzheimer’s disease amyloid proteopathy
Published in The FASEB journal (01-03-2006)“…Apolipoprotein (apo) E is an exchangeable apolipoprotein that plays an integral role in amyloid pathogenesis involved in Alzheimer’s disease (AD) and cerebral…”
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