Search Results - "Tamai, Keiko"

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor by Semënov, Mikhail, Tamai, Keiko, He, Xi

“…Sclerosteosis is an autosomal recessive disease that is characterized by overgrowth of bone tissue and is linked to mutations in the gene encoding the secreted…”
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Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions by Zeng, Xin, Huang, He, Tamai, Keiko, Zhang, Xinjun, Harada, Yuko, Yokota, Chika, Almeida, Karla, Wang, Jianbo, Doble, Brad, Woodgett, Jim, Wynshaw-Boris, Anthony, Hsieh, Jen-Chieh, He, Xi

“…Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor…”
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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation by Doble, Brad, He, Xi, Tamai, Keiko, Zeng, Xin, Woodgett, Jim, Huang, He, Li, Shitao, Habas, Raymond, Okamura, Heidi

“…Signalling by the Wnt family of secreted lipoproteins has essential functions in development and disease. The canonical Wnt/β-catenin pathway requires a…”
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Changes in oral and cognitive functions among older Japanese dental outpatients: A 2‐year follow‐up study by Mizutani, Shinsuke, Egashira, Rui, Yamaguchi, Masahiro, Tamai, Keiko, Yoshida, Mizuki, Kato, Tomotaka, Umezaki, Yojiro, Aoki, Hisae, Naito, Toru

“…Background The relationship between oral and cognitive functions among older people is highly debated. Objective To examine whether oral functions are related…”
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Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6 by MacDonald, Bryan T., Yokota, Chika, Tamai, Keiko, Zeng, Xin, He, Xi

“…Low density lipoprotein receptor-related protein 6 (LRP6) and its homologue LRP5 serve as Wnt co-receptors that are essential for the Wnt/β-catenin pathway…”
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LDL-receptor-related proteins in Wnt signal transduction by He, Xi, Tamai, Keiko, Semenov, Mikhail, Kato, Yoichi, Spokony, Rebecca, Liu, Chunming, Katsuyama, Yu, Hess, Fred, Saint-Jeannet, Jean-Pierre

“…The Wnt family of secreted signalling molecules are essential in embryo development and tumour formation. The Frizzled (Fz) family of serpentine receptors…”
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The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling by Nakamura, Yukio, Weidinger, Gilbert, Liang, Jennifer O, Aquilina-Beck, Allisan, Tamai, Keiko, Moon, Randall T, Warman, Matthew L

“…In humans, loss-of-function mutations in the gene encoding Wnt1 inducible signaling pathway protein 3 (WISP3) cause the autosomal-recessive skeletal disorder…”
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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases by MacDonald, Bryan T., Tamai, Keiko, He, Xi

“…Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-catenin controls embryonic development and adult homeostasis…”
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LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way by He, Xi, Semenov, Mikhail, Tamai, Keiko, Zeng, Xin

“…Wnt signaling through the canonical beta-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5…”
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Relationship between cerebral atrophy and number of present teeth in elderly individuals with cognitive decline by Egashira, Rui, Umezaki, Yojiro, Mizutani, Shinsuke, Obata, Toyoshi, Yamaguchi, Masahiro, Tamai, Keiko, Yoshida, Mizuki, Makino, Michiko, Naito, Toru

“…Recent shifts in the distribution of Japan's population towards older ages, have meant that the chance of encountering patients with dementia in dental clinics…”
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Low Tongue Strength and the Number of Teeth Present Are Associated with Cognitive Decline in Older Japanese Dental Outpatients: A Cross-Sectional Study by Egashira, Rui, Mizutani, Shinsuke, Yamaguchi, Masahiro, Kato, Tomotaka, Umezaki, Yojiro, Oku, Saori, Tamai, Keiko, Obata, Toyoshi, Naito, Toru

“…To mitigate the impact of dementia, initiating early intervention is important. This study aims to investigate the associations between deterioration in oral…”
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A Mechanism for Wnt Coreceptor Activation by Tamai, Keiko, Zeng, Xin, Liu, Chunming, Zhang, Xinjun, Harada, Yuko, Chang, Zhijie, He, Xi

“…LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are single-span transmembrane proteins essential for Wnt/β-catenin signaling,…”
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KHDC1B is a novel CPEB binding partner specifically expressed in mouse oocytes and early embryos by Cai, Congli, Tamai, Keiko, Molyneaux, Kathleen

“…mRNAs required for meiotic maturation and early embryonic development are stored in growing oocytes. These transcripts are translationally repressed until…”
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Kaiso is a bimodal modulator for Wnt/β-catenin signaling by Iioka, Hidekazu, Doerner, Stephanie K., Tamai, Keiko

“…The Wnt family of secreted ligands plays critical roles during embryonic development and tumorigenesis. Here we show that Kaiso, a dual specific DNA-binding…”
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Cytochalasin B inhibits morphogenetic movement and muscle differentiation of activin‐treated ectoderm in Xenopus by Tamai, Keiko, Yokota, Chika, Ariizumi, Takashi, Asashima, Makoto

“…Xenopus ectodermal explants (animal caps) begin to elongate after treatment with the mesoderm inducing factor activin A. This phenomenon mimics the convergent…”
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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6 by Semënov, Mikhail V, Tamai, Keiko, Brott, Barbara K, Kühl, Michael, Sokol, Sergei, He, Xi

“…Background: Dickkopf-1 (Dkk-1) is a head inducer secreted from the vertebrate head organizer and induces anterior development by antagonizing Wnt signaling…”
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Association of Dishevelled with the Clathrin AP-2 Adaptor Is Required for Frizzled Endocytosis and Planar Cell Polarity Signaling by Yu, Anan, Rual, Jean-François, Tamai, Keiko, Harada, Yuko, Vidal, Marc, He, Xi, Kirchhausen, Tomas

“…Upon activation by Wnt, the Frizzled receptor is internalized in a process that requires the recruitment of Dishevelled. We describe a novel interaction…”
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The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo by Chen, Dongxing, Bashur, Lindsay A, Liang, Bojian, Panattoni, Martina, Tamai, Keiko, Pardi, Ruggero, Zhou, Guang

“…The evolutionarily conserved transcriptional cofactor Jab1 plays critical roles in cell differentiation, proliferation, and apoptosis by modulating the…”
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A bimodal modulator in canonical Wnt signal transduction by Tamai, Keiko, Iioka, Hidekazu, Doerner, Stephanie

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Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6S by MacDonald, Bryan T., Yokota, Chika, Tamai, Keiko, Zeng, Xin, He, Xi

“…Low density lipoprotein receptor-related protein 6 (LRP6) and its homologue LRP5 serve as Wnt co-receptors that are essential for the Wnt/β-catenin pathway…”
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